Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Participants With Dementia of the Alzheimer's Type
Public ClinicalTrials.gov record NCT02442778. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (Deuterated [d6]-Dextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Participants with agitation secondary to dementia of the Alzheimer's type. The diagnosis of probable Alzheimer's disease (AD) will be based on the "2011 Diagnostic Guidelines for Alzheimer's Disease" issued by the National Institute on Aging (NIA)-Alzheimer's Association (AA) workgroups.
Study identification
- NCT ID
- NCT02442778
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 522 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 50 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 11, 2015 (Actual)
- Primary completion
- Aug 14, 2019 (Actual)
- Completion
- Sep 9, 2019 (Actual)
- Last update posted
- Sep 9, 2022
2015 – 2019
United States locations
- U.S. sites
- 79
- U.S. states
- 22
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Brain and Spine Center | Chandler | Arizona | 85226 | — |
| Territory Neurology & Research Institute | Tucson | Arizona | 85704 | — |
| Health Initiatives Research | Fayetteville | Arkansas | 72703 | — |
| Behavioral Research Specialists, LLC | Glendale | California | 91206 | — |
| Irvine Center for Clinical Research | Irvine | California | 92614 | — |
| California Neurological Services | Panorama City | California | 91402 | — |
| Havana Research Institute | Pasadena | California | 91105 | — |
| Pacific Research Network, Inc | San Diego | California | 92103 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Viking Clinical Research | Temecula | California | 92591 | — |
| Denver Neurological Research, LLC | Denver | Colorado | 80210 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Clinical Research Of Brandon, LLC | Brandon | Florida | 33511 | — |
| Meridien Research | Brooksville | Florida | 34601 | — |
| Moonshine Research Center, Inc | Doral | Florida | 33166 | — |
| Science Connections, LLC | Doral | Florida | 33166 | — |
| Finlay Medical Research Corp | Greenacres City | Florida | 33467 | — |
| Indago Research & Health Center, Inc. | Hialeah | Florida | 33012 | — |
| New Life Medical Research Center, Inc. | Hialeah | Florida | 33012 | — |
| Reliable Clinical Research,LLC | Hialeah | Florida | 33012 | — |
| Research in Miami, Inc | Hialeah | Florida | 33013 | — |
| The Research Center, Inc | Hialeah | Florida | 33013 | — |
| Maxblue Institute | Hialeah | Florida | 33018 | — |
| Clinical Neuroscience Solutions, Inc. | Jacksonville | Florida | 32256 | — |
| Alzheimer's Research and Treatment Center | Lake Worth | Florida | 33449 | — |
| Premier Clinical Research Institute, Inc. | Miami | Florida | 33122 | — |
| Project 4 Research | Miami | Florida | 33125 | — |
| BioMed Research Institute | Miami | Florida | 33126 | — |
| CCM Clinical Research Group | Miami | Florida | 33133 | — |
| DADE Research Center, LLC | Miami | Florida | 33135 | — |
| AMB Research Center, Inc. | Miami | Florida | 33144 | — |
| United Health Research Corp | Miami | Florida | 33144 | — |
| Advance Medical Research Center | Miami | Florida | 33165 | — |
| Coral Research Clinic Corp | Miami | Florida | 33175 | — |
| P&S Reasearch | Miami | Florida | 33175 | — |
| The Neurology Research Group, LLC | Miami | Florida | 33176 | — |
| Kendall Research Institute | Miami | Florida | 33183 | — |
| Nuovida Research Center Corp. | Miami | Florida | 33186 | — |
| Collier Neurologic Specialists, LLC | Naples | Florida | 34102 | — |
| Lazlo J. Mate, MD, PA | North Palm Beach | Florida | 33408 | — |
| Compass Research, LLC | Orlando | Florida | 32806 | — |
| IMIC Inc. | Palmetto Bay | Florida | 33157 | — |
| University of West Florida | Pensacola | Florida | 32514 | — |
| Neurology Research Institute Palm Beach, LLC | West Palm Beach | Florida | 33407 | — |
| Emory Brain Health Center | Atlanta | Georgia | 30329 | — |
| Columbus Research & Wellness Institute, INC | Columbus | Georgia | 31904 | — |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | — |
| Baptist Health Medical Group | Richmond | Kentucky | 40475 | — |
| The Samuel & Alexia Bratton Memory Clinic | Easton | Maryland | 21601 | — |
| Mir Neurology | Hagerstown | Maryland | 21742 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| AMAC Research Institute | North Dartmouth | Massachusetts | 02747 | — |
| Michigan State University | East Lansing | Michigan | 48824 | — |
| Center for Emotional Fitness | Cherry Hill | New Jersey | 08002 | — |
| The NeuroCognitive Institute | Mount Arlington | New Jersey | 07856 | — |
| Brooklyn Medical Institute | Brooklyn | New York | 11214 | — |
| Integrative Clinical Trials, LLC | Brooklyn | New York | 11229 | — |
| Eastside Comprehensive Medical Center, LLC | New York | New York | 10128 | — |
| Burke Rehabilitation Hospital | White Plains | New York | 10605 | — |
| Herbert Harris, MD, PhD, PA | Chapel Hill | North Carolina | 27517 | — |
| ANI Neurology PLLC dba Alzheimer's Memory Center | Charlotte | North Carolina | 28270 | — |
| Daystar Clinical Research Inc | Akron | Ohio | 44313 | — |
| Valley Medical Research | Centerville | Ohio | 45459 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health at Lakewood Hospital | Lakewood | Ohio | 44107 | — |
| Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania | 15009 | — |
| The Birches at Newton / Family Medical Associates | Levittown | Pennsylvania | 19056 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| RH Johnson VA Medical Center | Charleston | South Carolina | 29401 | — |
| BG Neurology | Spartanburg | South Carolina | 29307 | — |
| Texas Neurology, P.A. | Dallas | Texas | 75214 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Neurological Institute | Houston | Texas | 77030 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Texas Medical Research Associates, L.L.C. | San Antonio | Texas | 78238 | — |
| Pharmaceuticals Research Associates, Inc. | Salt Lake City | Utah | 84107 | — |
| Clinical Neuroscience Research Associates, Inc. dba The Memory Clinic | Bennington | Vermont | 05201 | — |
| Veteran Affairs Medical Center, Salem Virginia | Salem | Virginia | 24153 | — |
| IPC Research | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02442778, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 9, 2022 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02442778 live on ClinicalTrials.gov.