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Active, not recruiting Phase 3 Interventional Results available

Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

ClinicalTrials.gov ID: NCT02443077

Public ClinicalTrials.gov record NCT02443077. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 17, 2026, 12:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Double-Blind Phase III Study of Ibrutinib During and Following Autologous Stem Cell Transplantation Versus Placebo in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma of the Activated B-Cell Subtype

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase III trial studies ibrutinib to see how well it works compared to placebo when given before and after stem cell transplant in treating patients with diffuse large B-cell lymphoma that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). Before transplant, stem cells are taken from patients and stored. Patients then receive high doses of chemotherapy to kill cancer cells and make room for healthy cells. After treatment, the stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Ibrutinib is a drug that may stop the growth of cancer cells by blocking a protein that is needed for cell growth. It is not yet known whether adding ibrutinib to chemotherapy before and after stem cell transplant may help the transplant work better in patients with relapsed or refractory diffuse large B-cell lymphoma.

Study identification

NCT ID
NCT02443077
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
94 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 12, 2016 (Actual)
Primary completion
Jun 10, 2024 (Actual)
Completion
Dec 23, 2026 (Estimated)
Last update posted
Jul 31, 2026

2016 – 2026

United States locations

U.S. sites
280
U.S. states
36
U.S. cities
205
Facility City State ZIP Site status
Anchorage Associates in Radiation Medicine Anchorage Alaska 98508 —
Anchorage Radiation Therapy Center Anchorage Alaska 99504 —
Alaska Breast Care and Surgery LLC Anchorage Alaska 99508 —
Alaska Oncology and Hematology LLC Anchorage Alaska 99508 —
Alaska Women's Cancer Care Anchorage Alaska 99508 —
Anchorage Oncology Centre Anchorage Alaska 99508 —
Katmai Oncology Group Anchorage Alaska 99508 —
Providence Alaska Medical Center Anchorage Alaska 99508 —
Fairbanks Memorial Hospital Fairbanks Alaska 99701 —
Banner University Medical Center - Tucson Tucson Arizona 85719 —
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 —
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California 91505 —
City of Hope Comprehensive Cancer Center Duarte California 91010 —
UC San Diego Moores Cancer Center La Jolla California 92093 —
Loma Linda University Medical Center Loma Linda California 92354 —
Cedars-Sinai Medical Center Los Angeles California 90048 —
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 —
University of California Davis Comprehensive Cancer Center Sacramento California 95817 —
UCSF Medical Center-Parnassus San Francisco California 94143 —
Rocky Mountain Cancer Centers-Aurora Aurora Colorado 80012 —
The Medical Center of Aurora Aurora Colorado 80012 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
Boulder Community Foothills Hospital Boulder Colorado 80303 —
Rocky Mountain Cancer Centers-Boulder Boulder Colorado 80304 —
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 —
Denver Health Medical Center Denver Colorado 80204 —
National Jewish Health-Main Campus Denver Colorado 80206 —
The Women's Imaging Center Denver Colorado 80209 —
Colorado Blood Cancer Institute Denver Colorado 80218 —
Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado 80218 —
Rocky Mountain Cancer Centers-Midtown Denver Colorado 80218 —
Saint Joseph Hospital - Cancer Centers of Colorado Denver Colorado 80218 —
Rocky Mountain Cancer Centers-Rose Denver Colorado 80220 —
Mountain Blue Cancer Care Center - Swedish Englewood Colorado 80113 —
Swedish Medical Center Englewood Colorado 80113 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
National Jewish Health-Western Hematology Oncology Golden Colorado 80401 —
Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado 81501 —
Grand Valley Oncology Grand Junction Colorado 81505 —
Banner North Colorado Medical Center Greeley Colorado 80631 —
Good Samaritan Hospital - Cancer Centers of Colorado Lafayette Colorado 80026 —
Rocky Mountain Cancer Centers-Littleton Littleton Colorado 80120 —
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado 80124 —
Banner North Colorado Medical Center - Loveland Campus Loveland Colorado 80539 —
Intermountain Health Lutheran Hospital Wheat Ridge Colorado 80401 —
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510 —
Yale University New Haven Connecticut 06520 —
Beebe Medical Center Lewes Delaware 19958 —
Delaware Clinical and Laboratory Physicians PA Newark Delaware 19713 —
Helen F Graham Cancer Center Newark Delaware 19713 —
Medical Oncology Hematology Consultants PA Newark Delaware 19713 —
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 —
Beebe Health Campus Rehoboth Beach Delaware 19971 —
TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware 19973 —
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801 —
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 —
UF Health Cancer Institute - Gainesville Gainesville Florida 32610 —
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 —
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 —
Moffitt Cancer Center Tampa Florida 33612 —
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 —
Northside Hospital Atlanta Georgia 30342 —
Augusta University Medical Center Augusta Georgia 30912 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 —
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 —
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 —
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 —
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 —
Northwestern University Chicago Illinois 60611 —
Rush MD Anderson Cancer Center Chicago Illinois 60612 —
University of Illinois Chicago Illinois 60612 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Loyola University Medical Center Maywood Illinois 60153 —
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 —
Cancer Center of Kansas - Chanute Chanute Kansas 66720 —
Cancer Center of Kansas - Dodge City Dodge City Kansas 67801 —
Cancer Center of Kansas - El Dorado El Dorado Kansas 67042 —
Cancer Center of Kansas - Fort Scott Fort Scott Kansas 66701 —
Cancer Center of Kansas-Independence Independence Kansas 67301 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
Cancer Center of Kansas-Kingman Kingman Kansas 67068 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
Cancer Center of Kansas-Liberal Liberal Kansas 67905 —
Cancer Center of Kansas-Manhattan Manhattan Kansas 66502 —
Cancer Center of Kansas - McPherson McPherson Kansas 67460 —
Cancer Center of Kansas - Newton Newton Kansas 67114 —
Cancer Center of Kansas - Parsons Parsons Kansas 67357 —
Cancer Center of Kansas - Pratt Pratt Kansas 67124 —
Cancer Center of Kansas - Salina Salina Kansas 67401 —
Cancer Center of Kansas - Wellington Wellington Kansas 67152 —
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 —
Associates In Womens Health Wichita Kansas 67208 —
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas 67208 —
Ascension Via Christi Hospitals Wichita Wichita Kansas 67214 —
Cancer Center of Kansas - Wichita Wichita Kansas 67214 —
Cancer Center of Kansas - Winfield Winfield Kansas 67156 —
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 —
Baton Rouge General Medical Center Baton Rouge Louisiana 70806 —
Hematology/Oncology Clinic PLLC Baton Rouge Louisiana 70809 —
Tulane University School of Medicine New Orleans Louisiana 70112 —
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 —
LSU Health Sciences Center at Shreveport Shreveport Louisiana 71103 —
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 —
Simonds-Sinon Regional Cancer Center Fitchburg Massachusetts 01420 —
UMass Memorial Medical Center - University Campus Worcester Massachusetts 01655 —
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 —
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 —
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009 —
Beacon Kalamazoo Kalamazoo Michigan 49048 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120 —
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444 —
Corewell Health Reed City Hospital Reed City Michigan 49677 —
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph Michigan 49085 —
Munson Medical Center Traverse City Michigan 49684 —
University of Michigan Health - West Wyoming Michigan 49519 —
University of Minnesota/Masonic Cancer Center Minneapolis Minnesota 55455 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
SSM Health Saint Louis University Hospital St Louis Missouri 63104 —
Washington University School of Medicine St Louis Missouri 63110 —
Siteman Cancer Center-South County St Louis Missouri 63129 —
Community Hospital of Anaconda Anaconda Montana 59711 —
Billings Clinic Cancer Center Billings Montana 59101 —
Saint Vincent Healthcare Billings Montana 59101 —
Saint Vincent Frontier Cancer Center Billings Montana 59102 —
Bozeman Health Deaconess Hospital Bozeman Montana 59715 —
Benefis Sletten Cancer Institute Great Falls Montana 59405 —
Great Falls Clinic Great Falls Montana 59405 —
Saint Peter's Community Hospital Helena Montana 59601 —
Logan Health Medical Center Kalispell Montana 59901 —
Saint Patrick Hospital - Community Hospital Missoula Montana 59802 —
Community Medical Center Missoula Montana 59804 —
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 —
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 —
University of Nebraska Medical Center Omaha Nebraska 68198 —
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 —
Roswell Park Cancer Institute Buffalo New York 14263 —
NYP/Weill Cornell Medical Center New York New York 10065 —
Upstate Cancer Center at Oswego Oswego New York 13126 —
University of Rochester Rochester New York 14642 —
State University of New York Upstate Medical University Syracuse New York 13210 —
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 —
Montefiore Medical Center-Weiler Hospital The Bronx New York 10461 —
Children's Hospital at Montefiore The Bronx New York 10467 —
Montefiore Medical Center - Moses Campus The Bronx New York 10467 —
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 —
Duke University Medical Center Durham North Carolina 27710 —
Wake Forest University Health Sciences Winston-Salem North Carolina 27157 —
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 —
Case Western Reserve University Cleveland Ohio 44106 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Saint Charles Health System Bend Oregon 97701 —
Clackamas Radiation Oncology Center Clackamas Oregon 97015 —
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015 —
Bay Area Hospital Coos Bay Oregon 97420 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914 —
Providence Willamette Falls Medical Center Oregon City Oregon 97045 —
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Oregon Health and Science University Portland Oregon 97239 —
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania 18201 —
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 —
Lewistown Hospital Lewistown Pennsylvania 17044 —
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 —
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 —
Geisinger Cancer Services-Pottsville Pottsville Pennsylvania 17901 —
Community Medical Center Scranton Pennsylvania 18510 —
Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania 17870 —
Geisinger Medical Group State College Pennsylvania 16801 —
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Medical University of South Carolina Charleston South Carolina 29425 —
Prisma Health Cancer Institute - Laurens Clinton South Carolina 29325 —
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 —
Saint Francis Hospital Greenville South Carolina 29601 —
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605 —
Saint Francis Cancer Center Greenville South Carolina 29607 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 —
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 —
Avera Cancer Institute Sioux Falls South Dakota 57105 —
Vanderbilt-Ingram Cancer Center Cool Springs Franklin Tennessee 37067 —
Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee 38120 —
Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee 37204 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas 77030 —
American Fork Hospital / Huntsman Intermountain Cancer Center American Fork Utah 84003 —
Sandra L Maxwell Cancer Center Cedar City Utah 84720 —
Farmington Health Center Farmington Utah 84025 —
Logan Regional Hospital Logan Utah 84321 —
Intermountain Medical Center Murray Utah 84107 —
McKay-Dee Hospital Center Ogden Utah 84403 —
Utah Valley Regional Medical Center Provo Utah 84604 —
Riverton Hospital Riverton Utah 84065 —
Utah Cancer Specialists-Salt Lake City Salt Lake City Utah 84106 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
LDS Hospital Salt Lake City Utah 84143 —
South Jordan Health Center South Jordan Utah 84009 —
Saint George Regional Medical Center St. George Utah 84770 —
University of Virginia Cancer Center Charlottesville Virginia 22908 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
Providence Regional Cancer System-Aberdeen Aberdeen Washington 98520 —
Cancer Care Center at Island Hospital Anacortes Washington 98221 —
PeaceHealth Saint Joseph Medical Center Bellingham Washington 98225 —
Providence Regional Cancer System-Centralia Centralia Washington 98531 —
Swedish Cancer Institute-Edmonds Edmonds Washington 98026 —
Providence Regional Cancer Partnership Everett Washington 98201 —
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 —
Kadlec Clinic Hematology and Oncology Kennewick Washington 99336 —
Providence Regional Cancer System-Lacey Lacey Washington 98503 —
PeaceHealth Saint John Medical Center Longview Washington 98632 —
Pacific Gynecology Specialists Seattle Washington 98104 —
Swedish Medical Center-Ballard Campus Seattle Washington 98107 —
Fred Hutchinson Cancer Center Seattle Washington 98109 —
Kaiser Permanente Washington Seattle Washington 98112 —
Swedish Medical Center-Cherry Hill Seattle Washington 98122-5711 —
Swedish Medical Center-First Hill Seattle Washington 98122 —
University of Washington Medical Center - Montlake Seattle Washington 98195 —
Providence Regional Cancer System-Shelton Shelton Washington 98584 —
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane Washington 99204 —
MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane Washington 99218 —
MultiCare Deaconess Cancer and Blood Specialty Center - Valley Spokane Valley Washington 99216 —
PeaceHealth Southwest Medical Center Vancouver Washington 98664 —
Providence Saint Mary Regional Cancer Center Walla Walla Washington 99362 —
Providence Regional Cancer System-Yelm Yelm Washington 98597 —
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105 —
Marshfield Clinic-Chippewa Center Chippewa Falls Wisconsin 54729 —
Marshfield Clinic Cancer Center at Sacred Heart Eau Claire Wisconsin 54701 —
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 —
Aurora Health Center-Fond du Lac Fond du Lac Wisconsin 54937 —
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022 —
Aurora Cancer Care-Grafton Grafton Wisconsin 53024 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142 —
Marshfield Medical Center - Ladysmith Ladysmith Wisconsin 54848 —
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 —
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Marshfield Medical Center Marshfield Wisconsin 54449 —
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209 —
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Aurora Sinai Medical Center Milwaukee Wisconsin 53233 —
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 —
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904 —
Aurora Cancer Care-Racine Racine Wisconsin 53406 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241 —
Marshfield Clinic-Wausau Center Wausau Wisconsin 54401 —
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226 —
Aurora West Allis Medical Center West Allis Wisconsin 53227 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin 54494 —
Cheyenne Regional Medical Center-West Cheyenne Wyoming 82001 —
Billings Clinic-Cody Cody Wyoming 82414 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02443077, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 31, 2026 · Synced Oct 17, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02443077 live on ClinicalTrials.gov.

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