CAR-T Long Term Follow Up (LTFU) Study
Public ClinicalTrials.gov record NCT02445222. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Long Term Follow-Up of Patients Exposed to Lentiviral-Based CAR T-Cell Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Per Health Authorities guidelines for gene therapy medicinal products that utilize integrating vectors (e.g. lentiviral vectors), long term safety and efficacy follow up of treated patients is required. The purpose of this study is to monitor all patients exposed to CAR-T therapied for 15 years following their last CAR-T (e.g. CTL019) infusion to assess the risk of delayed adverse events (AEs), monitor for replication competent lentivirus (RCL) and assess long-term efficacy, including vector persistence.
Study identification
- NCT ID
- NCT02445222
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,105 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 0 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2, 2015 (Actual)
- Primary completion
- Apr 18, 2039 (Estimated)
- Completion
- Apr 18, 2039 (Estimated)
- Last update posted
- Oct 2, 2026
2015 – 2039
United States locations
- U.S. sites
- 42
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | Completed |
| City of Hope National Medical Center | Duarte | California | 91010-3000 | Recruiting |
| Childrens Hospital Los Angeles | Los Angeles | California | 90027 | Recruiting |
| UCLA Medical Center | Los Angeles | California | 90095 | Recruiting |
| UCSF Medical Center | San Francisco | California | 94143 | Recruiting |
| Stanford University Medical Center | Stanford | California | 94304 | Recruiting |
| Emory University School of Medicine-Winship Cancer Institute | Atlanta | Georgia | 30322 | Recruiting |
| Emory University School of Medicine/Winship Cancer Institute | Atlanta | Georgia | 30322 | Recruiting |
| Childrens Healthcare of Atlanta | Atlanta | Georgia | 30342 | Recruiting |
| Uni of Chi Medi Ctr Hema and Onco | Chicago | Illinois | 60637 | Recruiting |
| University of Chicago Medical Center, Hematology & Oncology | Chicago | Illinois | 60637 | Recruiting |
| University of Kansas Cancer Center SC | Westwood | Kansas | 66205 | Recruiting |
| University of Kansas Cancer Center | Westwood | Kansas | 66205 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Beth Israel Deaconess Med Center | Boston | Massachusetts | 02215 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109-2800 | Recruiting |
| Uni Of Michigan Health System | Ann Arbor | Michigan | 48109 | Recruiting |
| University of Michigan Health System SC CTL019 | Ann Arbor | Michigan | 48109 | Recruiting |
| Wayne State University-Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Withdrawn |
| Children s Mercy Hospital | Kansas City | Missouri | 64108 | Recruiting |
| Children's Mercy Hospital SC | Kansas City | Missouri | 64108 | Recruiting |
| Weill Cornell Medical College | New York | New York | 10065 | Withdrawn |
| Duke Unversity Medical Center SC - CTL019B2205J | Durham | North Carolina | 27705 | Recruiting |
| Duke Unversity Medical Center | Durham | North Carolina | 27705 | Recruiting |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229-3039 | Recruiting |
| Cinn Children Hosp Medical Center | Cincinnati | Ohio | 45229-3039 | Recruiting |
| Ohio ST Compr Cancer Ctr James Hosp | Columbus | Ohio | 43210 | Recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| Oregon Health Sciences University | Portland | Oregon | 97239 | Recruiting |
| The Childrens Hosp of Philadelphia | Philadelphia | Pennsylvania | 19104 | Recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Tennessee Oncology | Nashville | Tennessee | 37203 | Recruiting |
| UTSW/Children's Medical Center | Dallas | Texas | 75235 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| MD Anderson Cancer Center SC | Houston | Texas | 77030 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| University of Utah Clinical Trials Office | Salt Lake City | Utah | 84108 | Recruiting |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | Recruiting |
| University of Wisconsin Hospital | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 76 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02445222, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 2, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02445222 live on ClinicalTrials.gov.