ClinicalTrials.gov record
Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
ClinicalTrials.gov ID: NCT02446132
Public ClinicalTrials.gov record NCT02446132. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Long Term, Extension Study of the Safety and Efficacy of AVP-786 (Deuterated [d6] Dextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
Study identification
- NCT ID
- NCT02446132
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
- Industry
- Enrollment
- 1,197 participants
Conditions and interventions
Interventions
- AVP-786 Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 12, 2015
- Primary completion
- Sep 5, 2024
- Completion
- Sep 5, 2024
- Last update posted
- Oct 14, 2025
2015 – 2024
United States locations
- U.S. sites
- 171
- U.S. states
- 28
- U.S. cities
- 106
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MD First Research, LLC Site #767 | Chandler | Arizona | 85286 | — |
| NoesisPharma, LLC | Phoenix | Arizona | 85032 | — |
| Perseverance Research Center, LLC | Scottsdale | Arizona | 85254 | — |
| Health Initiatives Research | Fayetteville | Arkansas | 72703 | — |
| Advanced Research Center, Inc. Site #835 | Anaheim | California | 92805 | — |
| ATP Clinical Research, Inc. Site #763 | Costa Mesa | California | 92626 | — |
| Behavioral Research Specialists, LLC | Glendale | California | 91206 | — |
| Irvine Center for Clinical Research | Irvine | California | 92614 | — |
| Sheenath Clinical Service Site #770 | Lakewood | California | 90805 | — |
| Torrance Clinical Research Institute, Inc. Site #826 | Lomita | California | 90717 | — |
| Collaborative Neuroscience Network, LLC. | Long Beach | California | 90806 | — |
| Alliance for Wellness, Inc dba Alliance for Research Site #789 | Long Beach | California | 90807 | — |
| NRC Research Institute | Orange | California | 92868 | — |
| California Neurological Services | Panorama City | California | 91402 | — |
| Havana Research Institute Site 787 | Pasadena | California | 91105 | — |
| Havana Research Institute | Pasadena | California | 91105 | — |
| Pacific Research Network, Inc. #1 | San Diego | California | 92103 | — |
| Pacific Research Network, Inc. #2 | San Diego | California | 92103 | — |
| HB Clinical Trials Inc. | Santa Ana | California | 92704 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Viking Clinical Research | Temecula | California | 92591 | — |
| Lytle and Weiss, PLLC dba Clinical Trials of the Rockies | Denver | Colorado | 80209 | — |
| Coastal Connecticut Research, LLC | New London | Connecticut | 06320 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| Neurology of Central Florida Rsch Ctr Site #803 | Altamonte Springs | Florida | 32714 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Negron Research Services / Humanity Clinical Research Site# 766 | Aventura | Florida | 33180 | — |
| SFM Clinical Research, LLC Site #563 | Boca Raton | Florida | 33487 | — |
| Bradenton Research Center Site #834 | Bradenton | Florida | 34205 | — |
| Clinical Research Of Brandon, LLC Site #838 | Brandon | Florida | 33511 | — |
| Clinical Research of Brandon | Brandon | Florida | 33511 | — |
| Meridien Research | Brooksville | Florida | 34601 | — |
| Quantum Laboratories, Inc. | Deerfield Beach | Florida | 33064 | — |
| Moonshine Research Center, Inc | Doral | Florida | 33166 | — |
| Science Connections, LLC Site #814 | Doral | Florida | 33178 | — |
| Finlay Medical Research Corp | Greenacres City | Florida | 33467 | — |
| Direct Helpers Research Center #801 | Hialeah | Florida | 33012 | — |
| Indago Research & Health Center, Inc. | Hialeah | Florida | 33012 | — |
| New Life Medical Research Center, Inc. | Hialeah | Florida | 33012 | — |
| Reliable Clinical Research,LLC | Hialeah | Florida | 33012 | — |
| Research in Miami, Inc | Hialeah | Florida | 33013 | — |
| The Research Center, Inc | Hialeah | Florida | 33013 | — |
| Berma Research Group | Hialeah | Florida | 33016 | — |
| Galiz Research | Hialeah | Florida | 33016 | — |
| Maxblue Institute | Hialeah | Florida | 33018 | — |
| Clinical Neuroscience Solutions, Inc. | Jacksonville | Florida | 32256 | — |
| Alphab Global Research #793 | Jupiter | Florida | 33458 | — |
| SIH Research, LLC | Kissimmee | Florida | 34741 | — |
| Alzheimer's Research and Treatment Center #1 | Lake Worth | Florida | 33449 | — |
| Alzheimer's Research and Treatment Center #2 | Lake Worth | Florida | 33449 | — |
| Alzheimer's Research and Treatment Center #3 | Lake Worth | Florida | 33449 | — |
| Meridien Research Site #558 | Lakeland | Florida | 33803 | — |
| Innovative Clinical Research, Inc. Site #819 | Lauderhill | Florida | 33319 | — |
| Homestead Associates in Research Site# 797 | Miami | Florida | 33032 | — |
| Premier Clinical Research Institute, Inc. #1 | Miami | Florida | 33122 | — |
| Premier Clinical Research Institute, Inc. #2 | Miami | Florida | 33122 | — |
| Central Miami Medical Institute Site #798 | Miami | Florida | 33125 | — |
| Global Medical Institutes, LLC | Miami | Florida | 33125 | — |
| Optimus U Corp | Miami | Florida | 33125 | — |
| Project 4 Research #1 | Miami | Florida | 33125 | — |
| Project 4 Research #2 | Miami | Florida | 33125 | — |
| BioMed Research Institute | Miami | Florida | 33126 | — |
| Finlay Medical Research Corp Site #552 | Miami | Florida | 33126 | — |
| First Class Medical Services Site #807 | Miami | Florida | 33126 | — |
| CCM Clinical Research Group | Miami | Florida | 33133 | — |
| Innova Clinical Trials | Miami | Florida | 33133 | — |
| Advance Medical Research Center #1 | Miami | Florida | 33135 | — |
| Advance Medical Research Center #2 | Miami | Florida | 33135 | — |
| Dade Research Center Llc | Miami | Florida | 33135 | — |
| Vitae Researrch Center LLC | Miami | Florida | 33135 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Miami Jewish Health Systems, Inc. | Miami | Florida | 33137 | — |
| United Health Research Corp. #1 | Miami | Florida | 33144 | — |
| United Health Research Corp. #2 | Miami | Florida | 33144 | — |
| Advanced Medical Center Group | Miami | Florida | 33145 | — |
| Future Care Solution, LLC | Miami | Florida | 33165 | — |
| Reliant Medical Research LLC Site #811 | Miami | Florida | 33165 | — |
| Hope Research Network LLC Site #773 | Miami | Florida | 33166 | — |
| Clinical Research Associates of South Florida #1 | Miami | Florida | 33172 | — |
| Clinical Research Associates of South Florida #2 | Miami | Florida | 33172 | — |
| Coral Research Clinic Corp | Miami | Florida | 33175 | — |
| P&S RESEARCH, LLC. Site #805 | Miami | Florida | 33175 | — |
| Pharmax Research of South Florida | Miami | Florida | 33175 | — |
| Kendall Research Institute | Miami | Florida | 33183 | — |
| Nuovida Research Center Corp. | Miami | Florida | 33186 | — |
| New Med Research, Inc Site #812 | Miami Gardens | Florida | 33056 | — |
| Collier Neurologic Specialists, LLC | Naples | Florida | 34102 | — |
| Naples Research, Inc | Naples | Florida | 34102 | — |
| Bayside Clinical Research Site #556 | New Port Richey | Florida | 34655 | — |
| Research Centers of America, LLC | Oakland Park | Florida | 33334 | — |
| Compass Research, LLC | Orlando | Florida | 32806 | — |
| Combined Research Orlando Site #799 | Orlando | Florida | 32807 | — |
| Neurology Associates of Ormond Beach | Ormond Beach | Florida | 32174 | — |
| Innovation Medical Research Center | Palmetto Bay | Florida | 03157 | — |
| IMIC Inc. | Palmetto Bay | Florida | 33157 | — |
| Innovation Medical Research Center Site #802 | Palmetto Bay | Florida | 33157 | — |
| University of West Florida | Pensacola | Florida | 32514 | — |
| Neurostudies Inc. Site#796 | Port Charlotte | Florida | 33952 | — |
| Roskamp Institute | Sarasota | Florida | 34243 | — |
| Olympian Clinical Research | Tampa | Florida | 33609 | — |
| VICIS Clinical Research Inc. Site #777 | Tampa | Florida | 33615 | — |
| Compass Research North, LLC | The Villages | Florida | 32162 | — |
| Neurology Research Institute Palm Beach, LLC #1 | West Palm Beach | Florida | 33407 | — |
| Neurology Research Institute Palm Beach, LLC #2 | West Palm Beach | Florida | 33407 | — |
| Florida Premier Research Institute | Winter Park | Florida | 32789 | — |
| NeuroTrials Research Inc | Atlanta | Georgia | 30342 | — |
| Columbus Research & Wellness Institute, INC | Columbus | Georgia | 31904 | — |
| Medical Research & Health Education Foundation, Inc. | Columbus | Georgia | 31909 | — |
| NeuroStudies. Net, LLC | Decatur | Georgia | 30033 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | — |
| MidAmerica Neuroscience Research Foundation | Lenexa | Kansas | 66214 | — |
| Four Rivers Clinical Research Inc. | Paducah | Kentucky | 42003 | — |
| The Samuel & Alexia Bratton Memory Clinic | Easton | Maryland | 21601 | — |
| Mir Neurology | Hagerstown | Maryland | 21742 | — |
| Alzheimer Disease Center Site #804 | Braintree | Massachusetts | 02184 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Alzheimer's Disease Center | Quincy | Massachusetts | 02169 | — |
| Onyx Clinical Research, LLC | Caro | Michigan | 48723 | — |
| Michigan State University Department of Neurology | East Lansing | Michigan | 48824 | — |
| Oakland Medical Research Site #762 | Troy | Michigan | 48085 | — |
| Galen Research | Chesterfield | Missouri | 63005 | — |
| Millennium Psychiatric Associates, LLC | Creve Coeur | Missouri | 63141 | — |
| The NeuroCognitive Institute | Mount Arlington | New Jersey | 07856 | — |
| Bio Behavioral Health | Toms River | New Jersey | 08755 | — |
| Dent Neurologic Institute | Amherst | New York | 14226 | — |
| Integrative Clinical Trials LLC #1 | Brooklyn | New York | 11229 | — |
| Integrative Clinical Trials LLC #2 | Brooklyn | New York | 11229 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Manhattan Behavioral Medicine, PLLC | New York | New York | 10036 | — |
| Eastside Comprehensive Medical Center, LLC | New York | New York | 10128 | — |
| Nathan S. Kline Institute for Psychiatric Research #1 | Orangeburg | New York | 10962 | — |
| Nathan S. Kline Institute for Psychiatric Research #571 | Orangeburg | New York | 10962 | — |
| University of Rochester Medical Center | Rochester | New York | 14620 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| Burke Rehabilitation Hospital | White Plains | New York | 10605 | — |
| Herbert Harris, Md, Phd, Pa | Chapel Hill | North Carolina | 27517 | — |
| ANI Neurology PLLC dba Alzheimer's Memory Center | Charlotte | North Carolina | 28270 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Neurology and Neuroscience Associates, Inc. | Akron | Ohio | 44320 | — |
| Insight Clinical Trials, LLC Site #570 | Beachwood | Ohio | 44122 | — |
| Valley Medical Research Site #788 | Centerville | Ohio | 45459 | — |
| Valley Medical Research | Centerville | Ohio | 45459 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health at Lakewood Hospital | Lakewood | Ohio | 44107 | — |
| NorthStar Medical Research Site #778 | Middleburg Heights | Ohio | 44130 | — |
| IPS Research Company | Oklahoma City | Oklahoma | 73103 | — |
| Oklahoma Clinical Research Center | Oklahoma City | Oklahoma | 73112 | — |
| Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania | 15009 | — |
| Abington Neurological Associates, LTD | Willow Grove | Pennsylvania | 19090 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| RH Johnson VA Medical Center | Charleston | South Carolina | 29401 | — |
| Roper St. Francis Healthcare | Charleston | South Carolina | 29401 | — |
| BG Neurology | Spartanburg | South Carolina | 29307 | — |
| Texas Neurology, P.A. | Dallas | Texas | 75214 | — |
| Neurology Consultants of Dallas, PA | Dallas | Texas | 75231 | — |
| University Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| InSite Clinical Research Site #576 | DeSoto | Texas | 75115 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Neurological Institute | Houston | Texas | 77030 | — |
| PRX Research Site #825 | Mesquite | Texas | 75149 | — |
| Texas Medical Research Associates, L.L.C. | San Antonio | Texas | 78238 | — |
| Ericksen Research and Development | Clinton | Utah | 84015 | — |
| Pharmaceuticals Research Associates, Inc. | Salt Lake City | Utah | 84107 | — |
| Clinical Neuroscience Research Associates, Inc. dba The Memory Clinic | Bennington | Vermont | 05201 | — |
| Neuropsychiatric Associates | Woodstock | Vermont | 05091 | — |
| Veteran Affairs Medical Center, Salem Virginia | Salem | Virginia | 24153 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Core Clinical Research Site #772 | Everett | Washington | 98201 | — |
| IPC Research | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 56 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02446132, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2025 · Synced Jul 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02446132 live on ClinicalTrials.gov.