Safety, Pharmacokinetics and Preliminary Efficacy of Asimadoline in Pruritus Associated With Atopic Dermatitis
Public ClinicalTrials.gov record NCT02475447. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Multicenter Study to Evaluate the Safety, Pharmacokinetics and Preliminary Efficacy of Asimadoline in Adult Subjects With Pruritus Associated With Atopic Dermatitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Kappa-opioid receptors mediate the sensation of itch in animals and humans. Asimadoline is an orally active, selective kappa-opioid receptor agonist and has demonstrated efficacy in several preclinical pruritus models. The purpose of this Phase 2 study is to evaluate the safety, tolerability and clinical efficacy of asimadoline in patients with pruritus associated with atopic dermatitis.
Study identification
- NCT ID
- NCT02475447
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 249 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2015 (Actual)
- Primary completion
- Jun 2017 (Actual)
- Completion
- Jun 2017 (Actual)
- Last update posted
- Dec 13, 2017
2015 – 2017
United States locations
- U.S. sites
- 22
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Center of Alabama | Birmingham | Alabama | 35244 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| Axis Clinical Research | Los Angeles | California | 90036 | — |
| Tory Sullivan, MD PA | North Miami Beach | Florida | 33162 | — |
| Park Avenue Dermatology | Orange Park | Florida | 32073 | — |
| Olympian Clinical Research | Tampa | Florida | 33609 | — |
| Northwest Clinical Trials | Boise | Idaho | 83704 | — |
| Sneeze, Wheeze and Itch Associates, LLC | Normal | Illinois | 61761 | — |
| Forefront Dermatology | Carmel | Indiana | 46032 | — |
| MediSearch Clinical Trials | Saint Joseph | Missouri | 64506 | — |
| The Dermatology Group | Verona | New Jersey | 07044 | — |
| Corning Center for Clinical Research | Corning | New York | 14830 | — |
| UNC Dermatology and Skin Cancer Center | Chapel Hill | North Carolina | 27516 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania, Department of Dermatology | Philadelphia | Pennsylvania | 19104 | — |
| Temple Itch Center | Philadelphia | Pennsylvania | 19140 | — |
| Radiant Research, Inc. | Anderson | South Carolina | 29621 | — |
| Medical Research South | Charleston | South Carolina | 29407 | — |
| National Allergy and Asthma Research, LLC | North Charleston | South Carolina | 29420 | — |
| Dermatology Treatment and Research Center, PA | Dallas | Texas | 75230 | — |
| Sylvana Research Associates | San Antonio | Texas | 78229 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02475447, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 13, 2017 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02475447 live on ClinicalTrials.gov.