Specular Microscopy Study

ClinicalTrials.gov ID: NCT02478970

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ClinicalTrials.gov public records Last synced Nov 14, 2026, 10:12 PM EST

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Official title

Comparison of Clinical Evaluation of Endothelial Cells With Paracentral and Central Specular Microscopy

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The corneal endothelium plays an important role in regulating stromal hydration and maintaining the transparency of the cornea. For evaluating the cornea, the most important parameters are corneal endothelial morphology and central corneal thickness. The specular microscope does this. The image in specular microscope is obtained by the specular reflex at a regular, smooth-surfaced interface of two refractive indices, with the angle of the light passing into the cornea equal to the angle of reflection to the observer. To obtain a clear image, the endothelial apical surface must be smooth and uniform and the cornea must be transparent. Nowadays different types of specular microscope exist. The investigators propose to compare the endothelial cells with two specular microscopes: the Konan SP4000, which is the current model and used for standard of care, to the Nidek CEM-350, which is a newly marketed device. The investigators would like to evaluate the patients in the clinic and have assessments completed with both specular microscopes. Nidek will be loaning the specular microscope, NIDEK CEM-530, for the study.

Study identification

NCT ID: NCT02478970
Recruitment status: Withdrawn
Study type: Interventional
Phase: Not applicable
Lead sponsor: University of Michigan; Other
Enrollment: Not listed

Conditions and interventions

Conditions

Endotheliopathies

Interventions

Konan SP4000 Device
NIDEK CEM-350 Device

Device

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 2014 (Type not available)
Primary completion: May 2016 (Actual)
Completion: Jun 2016 (Actual)
Last update posted: Apr 28, 2017

2014 – 2016

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Kellogg Eye Center	Ann Arbor	Michigan	48105	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02478970, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 28, 2017 · Synced Nov 14, 2026