A Study Of PF-06410293 (Adalimumab-Pfizer) And Adalimumab (Humira®) In Combination With Methotrexate In Subjects With Active Rheumatoid Arthritis (REFLECTIONS B538-02).
Public ClinicalTrials.gov record NCT02480153. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3 RANDOMIZED, DOUBLE-BLIND STUDY ASSESSING THE EFFICACY AND SAFETY OF PF-06410293 AND ADALIMUMAB IN COMBINATION WITH METHOTREXATE IN SUBJECTS WITH MODERATELY TO SEVERELY ACTIVE RHEUMATOID ARTHRITIS WHO HAVE HAD AN INADEQUATE RESPONSE TO METHOTREXATE
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study will assess the efficacy, safety, and immunogenicity of PF-06410293 and adalimumab in combination with methotrexate in subjects with moderately to severly active rheumatoid arthritis who have had an inadequate response to methotrexate. In an additional optional portion of the study, during open label Treatment Period 3 (TP3), a subset of subjects used a Prefilled Pen (PFP) to administer up to 3 injections of their study treatment (PF-06410293) at home.
Study identification
- NCT ID
- NCT02480153
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 597 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 25, 2015 (Actual)
- Primary completion
- Aug 31, 2016 (Actual)
- Completion
- Dec 6, 2017 (Actual)
- Last update posted
- Jan 23, 2019
2015 – 2017
United States locations
- U.S. sites
- 49
- U.S. states
- 23
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| ArthroCare, Arthritis Care & Research P.C. | Gilbert | Arizona | 85234 | — |
| Arizona Arthritis & Rheumatology Associates, PC | Glendale | Arizona | 85306 | — |
| Arizona Arthritis & Rheumatology Associates, PC | Phoenix | Arizona | 85032 | — |
| St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| East Bay Rheumatology Medical Group, Inc. | San Leandro | California | 94578 | — |
| Westlake Medical Research | Thousand Oaks | California | 91360 | — |
| Inland Rheumatology Clinical Trials, Inc. | Upland | California | 91786 | — |
| Desert Valley Medical Group | Victorville | California | 92395 | — |
| Javed Rheumatology Associates, Inc | Newark | Delaware | 19713 | — |
| Arthritis and Rheumatic Disease Specialties | Aventura | Florida | 33180 | — |
| Robert W. Levin, MD, PA | Clearwater | Florida | 33765 | — |
| International Medical Research | Daytona Beach | Florida | 32117 | — |
| SIMED Arthritis Center | Gainesville | Florida | 32607 | — |
| Southeastern Integrated Medical, PL, d/b/a Florida Medical Research | Gainesville | Florida | 32607 | — |
| Rheumatology Associates of Central Florida, P.A. | Orlando | Florida | 32806 | — |
| Sarasota Arthritis Research Center | Sarasota | Florida | 34239 | — |
| Alastair C. Kennedy, MD | Vero Beach | Florida | 32960 | — |
| Indian River Primary Care | Vero Beach | Florida | 32960 | — |
| St Luke's Intermountain Research Center | Boise | Idaho | 83702 | — |
| St Luke' s Clinic | Meridian | Idaho | 83642 | — |
| Physician's Clinic of Iowa, P.C. | Cedar Rapids | Iowa | 52403 | — |
| Graves-Gilbert Clinic Bowling Green | Bowling Green | Kentucky | 42101 | — |
| The Center for Rheumatology and Bone Research | Wheaton | Maryland | 20902 | — |
| Bronson Internal Medicine and Rheumatology | Battle Creek | Michigan | 49015 | — |
| North Mississippi Medical Clinics, Inc. - Clinical Research | Tupelo | Mississippi | 38801 | — |
| Physician Research Collaboration, LLC | Lincoln | Nebraska | 68516 | — |
| Westroads Clinical Research, Inc. | Omaha | Nebraska | 68114 | — |
| Arthritis, Rheumatic & Back Disease Associates, P.A. | Voorhees Township | New Jersey | 08043 | — |
| Manhattan Medical Research | New York | New York | 10016 | — |
| Buffalo Rheumatology and Medicine PLLC | Orchard Park | New York | 14127 | — |
| Physicians East PA | Greenville | North Carolina | 27834 | — |
| Cincinnati Rheumatic Disease Study Group, Inc. | Cincinnati | Ohio | 45242 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Clinical Research of Reading, LLC | Wyomissing | Pennsylvania | 19610 | — |
| Low Country Rheumatology, PA | Charleston | South Carolina | 29406 | — |
| Regional Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Regional Medical Clinic - Rheumatology | Rapid City | South Dakota | 57701 | — |
| West Tennessee Research Institute | Jackson | Tennessee | 38305 | — |
| Ramesh C Gupta, M.D. | Memphis | Tennessee | 38119 | — |
| Amarillo Center for Clinical Research, Ltd. | Amarillo | Texas | 79124 | — |
| Austin Regional Clinic | Austin | Texas | 78731 | — |
| Metroplex Clinical Research Center | Dallas | Texas | 75231 | — |
| The Clinical Research Institute of Houston, LLC | Houston | Texas | 77090 | — |
| Accurate Clinical Research | League City | Texas | 77573 | — |
| Southwest Rheumatology Research, LLC | Mesquite | Texas | 75150 | — |
| Northwest Diagnostic Clinic, PA | Shenandoah | Texas | 77380 | — |
| Center for Arthritis and Rheumatic Diseases, P.C. | Chesapeake | Virginia | 23320 | — |
| Wenatchee Valley Hospitals & Clinics | Wenatchee | Washington | 98801 | — |
| Rheumatology and Pulmonary Clinic | Beckley | West Virginia | 25801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 134 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02480153, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 23, 2019 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02480153 live on ClinicalTrials.gov.