221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease
Public ClinicalTrials.gov record NCT02484547. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects With Early Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) \[ADAS-Cog 13\], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) \[ADCS-ADL-MCI\].
Study identification
- NCT ID
- NCT02484547
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,643 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 15, 2015 (Actual)
- Primary completion
- Aug 5, 2019 (Actual)
- Completion
- Aug 5, 2019 (Actual)
- Last update posted
- Sep 2, 2021
2015 – 2019
United States locations
- U.S. sites
- 58
- U.S. states
- 23
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Xenoscience Inc. | Phoenix | Arizona | 85013 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Institute for Memory Impairments | Irvine | California | 92607 | — |
| Renewal Behavioral Health | Long Beach | California | 85013 | — |
| USC Keck School of Medicine | Los Angeles | California | 90033 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Excell Research, Inc. | Oceanside | California | 92056 | — |
| Pacific Neuroscience Medical Group | Oxnard | California | 93030 | — |
| Anderson Clinical Research | Redlands | California | 92354 | — |
| Pacific Research Network | San Diego | California | 92103 | — |
| University of California San Diego Medical Center | San Diego | California | 92103 | — |
| California Pacific Medical Center | San Francisco | California | 94114 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| St Joseph Heritage Healthcare | Santa Rosa | California | 95403 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| University Of Colorado Denver | Aurora | Colorado | 80045 | — |
| IMMUNOe International Research Centers | Thornton | Colorado | 80233 | — |
| Associated Neurologists of Southern Connecticut, PC | Fairfield | Connecticut | 06824 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06520 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Bradenton Research Center, Inc. | Bradenton | Florida | 34205 | — |
| Meridien Research | Brooksville | Florida | 34601 | — |
| Quantum Laboratories Inc. | Deerfield Beach | Florida | 33064 | — |
| Infinity Clinical Research, LLC | Hollywood | Florida | 33021 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32801 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Emory University Cognitive Neurology Clinic & ADRC | Atlanta | Georgia | 30329 | — |
| Medical Research Health and Education Foundation, Inc | Columbus | Georgia | 31909 | — |
| NeuroStudies.net, LLC | Decatur | Georgia | 30033 | — |
| Josephson, Wallack, Munshower Neurology, PC | Indianapolis | Indiana | 46256 | — |
| McLean Hospital | Belmont | Massachusetts | 02478 | — |
| Boston Center for Memory | Newton | Massachusetts | 05201 | — |
| Hattiesburg Clinic, PA | Hattiesburg | Mississippi | 39401 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| ActivMed Practices & Research | Portsmouth | New Hampshire | 03801 | — |
| AdvanceMed Research | Lawrenceville | New Jersey | 08648 | — |
| Empire Neurology, PC | Latham | New York | 12110 | — |
| Weill Cornell Medical College-New York Presbyterian Hospital | New York | New York | 10021 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| PMG Research of Winston-Salem, LLC | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27103 | — |
| Ohio State University Medical Center | Dublin | Ohio | 43017 | — |
| Lehigh Center for Clinical Research, LLC | Allentown | Pennsylvania | 18104 | — |
| Penn Memory Center | Philadelphia | Pennsylvania | 19104 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Roper St. Francis Healthcare | North Charleston | South Carolina | 29406-6076 | — |
| Senior Adult Specialty Research | Austin | Texas | 78757 | — |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84132 | — |
| Clinical Neuroscience Research Association, Inc | Bennington | Vermont | 05201 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Northwest Neurological, PLLC | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 122 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02484547, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 2, 2021 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02484547 live on ClinicalTrials.gov.