Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer
Public ClinicalTrials.gov record NCT02492711. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized Study of Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of Patients With HER2+ Metastatic Breast Cancer Who Have Received Prior Anti-HER2 Therapies and Require Systemic Treatment
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine whether patients with metastatic breast cancer treated with margetuximab plus chemotherapy have longer progression free survival (PFS) and overall survival (OS) than patients treated with trastuzumab plus chemotherapy. A non-randomized sub-study cohort of approximately 88 patients will be enrolled to evaluate the safety of a reduced margetuximab infusion rate in patients receiving margetuximab either as monotherapy or in combination with chemotherapy.
Study identification
- NCT ID
- NCT02492711
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 624 participants
Conditions and interventions
Conditions
Interventions
- Margetuximab Biological
- Trastuzumab Biological
- Physician's choice of chemotherapy. Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 24, 2015 (Actual)
- Primary completion
- Aug 11, 2021 (Actual)
- Completion
- Jun 14, 2022 (Actual)
- Last update posted
- Mar 17, 2025
2015 – 2022
United States locations
- U.S. sites
- 62
- U.S. states
- 28
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Center | Chandler | Arizona | 85224 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Western Regional Medical Center, Inc. | Goodyear | Arizona | 85338 | — |
| East Valley Hematology And Oncology | Burbank | California | 91505 | — |
| UCLA Hematology Oncology Santa Monica | Los Angeles | California | 90095 | — |
| UC Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| University of California, San Francisco Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| Kaiser Permenente Medical Center | Vallejo | California | 94589 | — |
| Poudre Valley Health Care, Inc. | Fort Collins | Colorado | 80528 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33916 | — |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| Florida Cancer Specialists | New Port Richey | Florida | 34655 | — |
| Orlndo Health Cancer Center | Orlando | Florida | 32806 | — |
| Hem-Onc Associates | Port Saint Lucie | Florida | 34952 | — |
| Palm Beach Cancer Center | West Palm Beach | Florida | 33401 | — |
| Piedmont Cancer Institute, P.C. | Atlanta | Georgia | 30318 | — |
| Northwest Georgia Oncology Centers, PC | Marietta | Georgia | 30060 | — |
| CTCA - Southeastern Regional Medical Center | Newnan | Georgia | 30265 | — |
| Kaiser Permanente Hawaii Moanalua Medical Center | Honolulu | Hawaii | 96819 | — |
| Northwestern University Feinberg School of Medicine | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| CTCA - Midwestern Regional Medical Center | Zion | Illinois | 60099 | — |
| Indiana University Health Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| ARH Cancer Clinic | Hazard | Kentucky | 41701 | — |
| St. Joseph's Hospital | Lexington | Kentucky | 40504 | — |
| Touro Infirmary Hospital | New Orleans | Louisiana | 70115 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Tufts-NEMC Cancer Center | Boston | Massachusetts | 02111 | — |
| Forrest General Hospital | Hattiesburg | Mississippi | 39401 | — |
| Saint Luke's Cancer Specialists | Kansas City | Missouri | 64111 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Dartmouth-Hitchcock - Norris C | Lebanon | New Hampshire | 03756 | — |
| New Jersey Hematology Oncology Associates | Brick | New Jersey | 08724 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Saint Barnabas Medical Center - The Cancer Center | Livingston | New Jersey | 07039 | — |
| New Mexico Cancer Care Alliance (NMCCA) | Albuquerque | New Mexico | 87106 | — |
| Queens Hospital Center | Jamaica | New York | 11432 | — |
| ProHEALTH CARE Associates, LLP | Lake Success | New York | 11042 | — |
| New York University Clinical Cancer Center | New York | New York | 10016 | — |
| Wake Forest University Baptist Medical Center (WFUBMC) | Winston-Salem | North Carolina | 27157 | — |
| Mercy Physicians Of Oklahoma | Oklahoma City | Oklahoma | 73120 | — |
| Pinnacle Health Cancer Institute | Harrisburg | Pennsylvania | 17109 | — |
| Monongahela Valley Hospital | Monongahela | Pennsylvania | 15063 | — |
| CTCA - Eastern Regional Medical Center, Inc. | Philadelphia | Pennsylvania | 19124 | — |
| Guthrie Medical Group, PC | Sayre | Pennsylvania | 18840 | — |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | — |
| The Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Austin Cancer Center | Austin | Texas | 78758 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| The Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Fort Belvoir Community Hospital | Fort Belvoir | Virginia | 22060 | — |
| Swedish Cancer Institute/ Swedish Health Services | Seattle | Washington | 98104 | — |
| University of Washington/ Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| Cancer Care Northwest, PS | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 105 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02492711, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2025 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02492711 live on ClinicalTrials.gov.