Study of SRP-4045 (Casimersen) and SRP-4053 (Golodirsen) in Participants With Duchenne Muscular Dystrophy (DMD)
Public ClinicalTrials.gov record NCT02500381. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Placebo-Controlled, Multi-Center Study With an Open-Label Extension to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients With Duchenne Muscular Dystrophy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main objective of this study is to evaluate the efficacy of SRP-4045 (casimersen) and SRP-4053 (golodirsen) compared to placebo in participants with DMD with out-of-frame deletion mutations amenable to skipping exon 45 and exon 53, respectively.
Study identification
- NCT ID
- NCT02500381
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 228 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 6 Years to 13 Years
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 28, 2016 (Actual)
- Primary completion
- Nov 12, 2024 (Actual)
- Completion
- Oct 16, 2025 (Actual)
- Last update posted
- Nov 18, 2025
2016 – 2025
United States locations
- U.S. sites
- 23
- U.S. states
- 18
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neuromuscular Research Center | Phoenix | Arizona | 85028 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| David Geffen School of Medicine, UCLA | Los Angeles | California | 90095 | — |
| Rady Children's Hospital San Diego/ UCSD | San Diego | California | 92123 | — |
| Stanford University School of Medicine/Medical Center | Stanford | California | 94305 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| NW Florida Clinical Research Group, LLC | Gulf Breeze | Florida | 32561 | — |
| Center for Integrative Rare Disease Research (CIRDR) | Atlanta | Georgia | 30318 | — |
| Ann and Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611 | — |
| University of Iowa Children's Hospital | Iowa City | Iowa | 52242 | — |
| University of Kansas, Medical Center | Kansas City | Kansas | 66160 | — |
| Boston Children's Hospital | Boston | Massachusetts | 02115 | — |
| St. Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| Las Vegas Clinic | Las Vegas | Nevada | 89145 | — |
| University of Rochester Clinical Research Center | Rochester | New York | 14642 | — |
| Cincinnati Children's Hospital Medical Center (CCHMC) | Cincinnati | Ohio | 45229 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| Shriners Hospital for Children | Portland | Oregon | 97239 | — |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15224 | — |
| Children's Medical Center Dallas | Dallas | Texas | 75235 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Children's Hospital of the King's Daughters | Norfolk | Virginia | 23507 | — |
| Children's Hospital of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 53 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02500381, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 18, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02500381 live on ClinicalTrials.gov.