Tolerability, Safety, and Activity of SRX246 in Irritable Subjects With Huntington's Disease

ClinicalTrials.gov ID: NCT02507284

Public ClinicalTrials.gov record NCT02507284. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

An Exploratory Phase II Study to Determine the Tolerability, Safety, and Activity of a Novel Vasopressin 1a Receptor Antagonist (SRX246) in Irritable Subjects With Huntington's Disease (HD)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study evaluates the tolerability, safety and activity of SRX246 in the treatment of irritability in patients with Huntington's disease. Two-thirds of all participants will receive SRX246, while the other third will receive a placebo.

Study identification

NCT ID: NCT02507284
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2
Lead sponsor: Azevan Pharmaceuticals; Industry
Enrollment: 106 participants

Conditions and interventions

Conditions

Interventions

SRX246 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 10, 2016 (Actual)
Primary completion: Sep 10, 2018 (Actual)
Completion: Dec 21, 2018 (Actual)
Last update posted: Jul 20, 2023

2016 – 2018

United States locations

U.S. sites: 22
U.S. states: 18
U.S. cities: 22

Facility	City	State	ZIP	Site status
University of Alabama	Birmingham	Alabama	35233	—
UCLA, Neurology Clinic	Los Angeles	California	90095	—
UC Davis Medical Center, Department of Neurology, CTSC Clinical Research Center	Sacramento	California	95817	—
University of Colorado Hospital Translational Research Center	Aurora	Colorado	80045	—
University of Miami, Miller School of Medicine, Jackson Behavioral Health Hospital	Miami	Florida	33136	—
Emory University	Atlanta	Georgia	30329	—
Northwestern Out-Patient Neurology Clinic	Chicago	Illinois	60611	—
University of Kansas Medical Center	Kansas City	Kansas	66160	—
Massachusetts General Hospital	Charlestown	Massachusetts	02129	—
Washington University School of Medicine	St Louis	Missouri	63110	—
SUNY Stony Brook Clinical Research Center, Department of Neurology	East Setauket	New York	11733	—
Columbia University Medical Center, New York Presbyterian Hospital	New York	New York	10032	—
University of Rochester Medical Center	Rochester	New York	14618	—
University Medical Arts Building	Cincinnati	Ohio	45219	—
Ohio State University, Wexner Medical Center, Department of Neurology	Columbus	Ohio	43221	—
Oregon Health and Science University	Portland	Oregon	97239	—
University of Pittsburgh Medical Center, Department of Neurology	Pittsburgh	Pennsylvania	15213	—
Vanderbilt Clinical Research Center	Nashville	Tennessee	37232	—
UT Southwestern Medical Center	Dallas	Texas	75390	—
University of Utah, Department of Neurology	Salt Lake City	Utah	84108	—
University of Virginia Health System, Department of Neurology	Charlottesville	Virginia	22908	—
Swedish Neuroscience Institute	Seattle	Washington	98122	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02507284, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 20, 2023 · Synced Oct 21, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02507284 live on ClinicalTrials.gov.

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