A Multicenter Study to Evaluate the Efficacy and Safety of Cinryze® for the Treatment of Acute Antibody-mediated Rejection in Participants With Kidney Transplant
Public ClinicalTrials.gov record NCT02547220. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-blind Placebo-controlled Study to Evaluate the Efficacy and Safety of Cinryze® (C1 Esterase Inhibitor [Human]) for the Treatment of Acute Antibody-mediated Rejection in Kidney Transplant Patients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of the study is to evaluate the efficacy of CINRYZE administered with plasmapheresis, plasma exchange, or immune adsorption treatments and sucrose-free immunoglobulin (IVIg) for the treatment of acute antibody-mediated rejection (AMR) of renal allograft in kidney transplant recipients as measured by the proportion of participants with new or worsening transplant glomerulopathy (TG) at 6 months after treatment initiation.
Study identification
- NCT ID
- NCT02547220
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 39 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 20, 2016 (Actual)
- Primary completion
- May 31, 2019 (Actual)
- Completion
- May 31, 2019 (Actual)
- Last update posted
- Jul 13, 2020
2016 – 2019
United States locations
- U.S. sites
- 29
- U.S. states
- 18
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Kidney Transplant Research Office at UCLA | Los Angeles | California | 90024 | — |
| Keck School of Medicine at USC | Los Angeles | California | 90033 | — |
| University of California San Francisco | San Francisco | California | 94110 | — |
| University Of Colorado School Of Medicine | Aurora | Colorado | 80045 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20057 | — |
| Jackson Memorial Hospital | Miami | Florida | 33136 | — |
| Florida Hospital Transplant Institute | Orlando | Florida | 32804 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Brigham and Womens Hospital | Boston | Massachusetts | 02115 | — |
| University of Minnesota | Minneapolis | Minnesota | 55414 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| New York Presbyterian Hospital - Weill-Cornell | New York | New York | 10065 | — |
| NYU Longone Medical Center | White Plains | New York | 10605 | — |
| University of Cincinnati | Cincinnati | Ohio | 45220 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| INTEGRIS Nazih Zuhdi Transplant Institute | Oklahoma City | Oklahoma | 73112 | — |
| University of Pittsburgh Medical Center | Monroeville | Pennsylvania | 15146 | — |
| University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19104 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37204 | — |
| Baylor All Saints Medical Center | Fort Worth | Texas | 76104 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02547220, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 13, 2020 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02547220 live on ClinicalTrials.gov.