A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley)
Public ClinicalTrials.gov record NCT02554812. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 1B/2 OPEN-LABEL STUDY TO EVALUATE SAFETY, CLINICAL ACTIVITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF AVELUMAB (MSB0010718C) IN COMBINATION WITH OTHER CANCER IMMUNOTHERAPIES IN PATIENTS WITH ADVANCED MALIGNANCIES
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 1b/2 dose-optimization study to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of avelumab (MSB0010718C) in combination with other cancer immunotherapies in patients with locally advanced or metastatic solid tumors. The primary purpose is to assess the safety and early signs of efficacy of various avelumab combinations with other cancer immunotherapies, optimizing dosing regimens as appropriate, in a limited series of indications.
Study identification
- NCT ID
- NCT02554812
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 409 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 9, 2015 (Actual)
- Primary completion
- Mar 23, 2023 (Actual)
- Completion
- Mar 23, 2023 (Actual)
- Last update posted
- Jul 30, 2024
2015 – 2023
United States locations
- U.S. sites
- 57
- U.S. states
- 13
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCSD Medical Center - Encinitas | Encinitas | California | 92024 | — |
| Koman Family Outpatient Pavilion | La Jolla | California | 92037 | — |
| UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) | La Jolla | California | 92037 | — |
| UC San Diego Perlman Medical Offices | La Jolla | California | 92037 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| UCLA Clinical Research Unit (Adminstration Office) | Los Angeles | California | 90024 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | — |
| UCLA Hematology-Oncology Clinic | Los Angeles | California | 90095 | — |
| UCLA Hematology-Oncology Infusion Center | Los Angeles | California | 90095 | — |
| UC San Diego Medical Center - Hillcrest | San Diego | California | 92103 | — |
| UCSD Medical Center - Vista | Vista | California | 92081 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Mount Sinai Comprehensive Cancer Center - Aventura | Aventura | Florida | 33180 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | — |
| H Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Michigan Hospitals | Ann Arbor | Michigan | 48109-5008 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Investigational Pharmacy, Karmanos Cancer Center | Detroit | Michigan | 48201 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Karmanos Cancer Institute Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| VA NY Harbor Healthcare System | New York | New York | 10010 | — |
| NYU Investigational Pharmacy | New York | New York | 10016 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| NYU Laura and Isaac Perlmutter Cancer Center | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Research Pharmacy #PH# | New York | New York | 10065 | — |
| Weill Cornell Medical College/New York Presbyterian Hospital | New York | New York | 10065 | — |
| Sampson Regional Medical Center | Clinton | North Carolina | 28328 | — |
| Southeastern Medical Oncology Center | Clinton | North Carolina | 28328 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| Onslow Memorial Hospital | Jacksonville | North Carolina | 28546 | — |
| Southeastern Medical Oncology Center | Jacksonville | North Carolina | 28546 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15232 | — |
| UPCI Investigational Drug Service | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Miriam Hospital | Providence | Rhode Island | 02906 | — |
| Sanford Cancer Center Oncology Clinic & Pharmacy | Sioux Falls | South Dakota | 57104 | — |
| Sanford Gynecologic Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Sanford Interventional Radiology | Sioux Falls | South Dakota | 57104 | — |
| Sanford ENT Clinic | Sioux Falls | South Dakota | 57105 | — |
| Sanford Research | Sioux Falls | South Dakota | 57105 | — |
| Sanford USD Medical Center | Sioux Falls | South Dakota | 57105 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| The Sarah Cannon Research Institute / Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | — |
| Vanderbilt University Oncology Pharmacy | Nashville | Tennessee | 37232 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75235 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| UT Southwestern Simmons Comprehensive Cancer Center | Dallas | Texas | 75390 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02554812, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2024 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02554812 live on ClinicalTrials.gov.