Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Public ClinicalTrials.gov record NCT02559206. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomized, Double-blind, Double-dummy, Placebo-controlled, Parallel-group, Dose-range-finding Study of Two Delayed Release Formulations of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objectives of this study are to evaluate the safety, efficacy, and dose response of two delayed release formulations of linaclotide (DR; DR formulation 1 is DR1; DR formulation 2 is DR2) administered orally to patients with irritable bowel syndrome with constipation (IBS-C). Additional objectives include understanding how the two DR formulations compare with each other and with the FDA-approved 290 μg LINZESS® (the immediate release \[IR\] formulation of linaclotide).
Study identification
- NCT ID
- NCT02559206
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 759 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 22, 2015 (Actual)
- Primary completion
- Sep 30, 2016 (Actual)
- Completion
- Sep 30, 2016 (Actual)
- Last update posted
- Apr 24, 2020
2015 – 2016
United States locations
- U.S. sites
- 71
- U.S. states
- 27
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Investigational Site | Huntsville | Alabama | 35801 | — |
| Ironwood Investigational Site | Phoenix | Arizona | 85018 | — |
| Ironwood Investigational Site | Tucson | Arizona | 85712 | — |
| Ironwood Investigational Site | North Little Rock | Arkansas | 72117 | — |
| Ironwood Investigational Site | Anaheim | California | 92801 | — |
| Ironwood Investigational Site | Chula Vista | California | 91910 | — |
| Ironwood Investigational Site | Garden Grove | California | 92843 | — |
| Ironwood Investigational Site | La Mesa | California | 91942 | — |
| Ironwood Investigational Site | Newport Beach | California | 92660 | — |
| Ironwood Investigational Site | Orange | California | 92868 | — |
| Ironwood Investigational Site | San Diego | California | 92108 | — |
| Ironwood Investigational Site | Thousand Oaks | California | 91360 | — |
| Ironwood Investigational Site | Colorado Springs | Colorado | 80904 | — |
| Ironwood Investigational Site | Bristol | Connecticut | 06010 | — |
| Ironwood Investigational Site | Waterbury | Connecticut | 06708 | — |
| Ironwood Investigational Site | Hialeah | Florida | 33016 | — |
| Ironwood Investigational Site | Kissimmee | Florida | 34744 | — |
| Ironwood Investigational Site | Miami | Florida | 33015 | — |
| Ironwood Investigational Site | Miami | Florida | 33135 | — |
| Ironwood Investigational Site | Miami | Florida | 33165 | — |
| Ironwood Investigational Site | Miami | Florida | 33175 | — |
| Ironwood Investigational Site | Orlando | Florida | 32806 | — |
| Ironwood Investigational Site | South Miami | Florida | 33143 | — |
| Ironwood Investigational Site | Tampa | Florida | 33634 | — |
| Ironwood Investigational Site | West Palm Beach | Florida | 33409 | — |
| Ironwood Investigational Site | Atlanta | Georgia | 30328 | — |
| Ironwood Investigational Site | Oakwood | Georgia | 30566 | — |
| Ironwood Investigational Site | Sandy Springs | Georgia | 30328 | — |
| Ironwood Investigational Site | Evansville | Indiana | 47714 | — |
| Ironwood Investigational Site | Bastrop | Louisiana | 71220 | — |
| Ironwood Investigational Site | Metairie | Louisiana | 70006 | — |
| Ironwood Investigational Site | Shreveport | Louisiana | 71105 | — |
| Ironwood Investigational Site | Baltimore | Maryland | 21215 | — |
| Ironwood Investigational Site | Chevy Chase | Maryland | 20815 | — |
| Ironwood Investigational Site | Boston | Massachusetts | 02131 | — |
| Ironwood Investigational Site | Watertown | Massachusetts | 02472 | — |
| Ironwood Investigational Site | Chesterfield | Michigan | 48047 | — |
| Ironwood Investigational Site | Wyoming | Michigan | 49519 | — |
| Ironwood Investigational Site | Jackson | Mississippi | 39202 | — |
| Ironwood Investigational Site | St Louis | Missouri | 63128-2197 | — |
| Ironwood Investigational Site | Bozeman | Montana | 59718 | — |
| Ironwood Investigational Site | Las Vegas | Nevada | 89119 | — |
| Ironwood Investigational Site | Las Vegas | Nevada | 89121 | — |
| Ironwood Investigational Site | Brooklyn | New York | 11206 | — |
| Ironwood Investigational Site | Charlotte | North Carolina | 28210 | — |
| Ironwood Investigational Site | Concord | North Carolina | 28025 | — |
| Ironwood Investigational Site | Davidson | North Carolina | 28036 | — |
| Ironwood Investigational Site | Fayetteville | North Carolina | 28304 | — |
| Ironwood Investigational Site | Wilmington | North Carolina | 28401 | — |
| Ironwood Investigational Site | Winston-Salem | North Carolina | 27103 | — |
| Ironwood Investigational Site | Cincinnati | Ohio | 45219 | — |
| Ironwood Investigational Site | Cincinnati | Ohio | 45224 | — |
| Ironwood Investigational Site | Mentor | Ohio | 44060 | — |
| Ironwood Investigational Site | Xenia | Ohio | 45385 | — |
| Ironwood Investigational Site | Pittsburgh | Pennsylvania | 15206 | — |
| Ironwood Investigational Site | Dakota Dunes | South Dakota | 57049 | — |
| Ironwood Investigational Site | Bristol | Tennessee | 37620 | — |
| Ironwood Investigational Site | Chattanooga | Tennessee | 37421 | — |
| Ironwood Investigational Site | Knoxville | Tennessee | 37909 | — |
| Ironwood Investigational Site | Arlington | Texas | 76012 | — |
| Ironwood Investigational Site | Beaumont | Texas | 77001 | — |
| Ironwood Investigational Site | El Paso | Texas | 79905 | — |
| Ironwood Investigational Site | Houston | Texas | 77074 | — |
| Ironwood Investigational Site | San Antonio | Texas | 78209 | — |
| Ironwood Investigational Site | San Antonio | Texas | 78229 | — |
| Ironwood Investigational Site | San Antonio | Texas | 78258 | — |
| Ironwood Investigational Site | Ogden | Utah | 84405 | — |
| Ironwood Investigational Site | Sandy City | Utah | 84094 | — |
| Ironwood Investigational Site | Christiansburg | Virginia | 24073 | — |
| Ironwood Investigational Site | Lynchburg | Virginia | 24502 | — |
| Ironwood Investigational Site | La Crosse | Wisconsin | 54601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02559206, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 24, 2020 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02559206 live on ClinicalTrials.gov.