Controlled Study of Rigosertib Versus Physician's Choice of Treatment in MDS Patients After Failure of an HMA
Public ClinicalTrials.gov record NCT02562443. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, International, Randomized, Controlled Study of Rigosertib Versus Physician's Choice of Treatment in Patients With Myelodysplastic Syndrome After Failure of a Hypomethylating Agent
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study's primary objective \[in a population of patients with MDS after failure of treatment with azacitidine (AZA) or decitabine (DAC)\], is to compare the overall survival (OS) of patients in the rigosertib group vs the Physician's Choice group, in all patients and in a subgroup of patients with IPSS-R very high risk.
Study identification
- NCT ID
- NCT02562443
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 372 participants
Conditions and interventions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 81 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2, 2015 (Actual)
- Primary completion
- Jul 26, 2020 (Actual)
- Completion
- Jul 26, 2021 (Actual)
- Last update posted
- Sep 26, 2022
2015 – 2021
United States locations
- U.S. sites
- 32
- U.S. states
- 17
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| UCLA Medical Center | Los Angeles | California | 90095 | — |
| Cancer Specialists of North Florida | Fleming Island | Florida | 32003 | — |
| UF Health Shands Cancer Hospital | Gainesville | Florida | 32608 | — |
| Mid Florida Hematology and Oncology Centers | Orange City | Florida | 32763 | — |
| Advanced Research Institute, Inc | St. Petersburg | Florida | 33710 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Illinois Cancer Center | Chicago | Illinois | 60612 | — |
| Loyola University Chicago at Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Indiana University Health Hospital | Indianapolis | Indiana | 46202 | — |
| The University of Kansas Cancer Center | Westwood | Kansas | 66205 | — |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | — |
| University of Maryland Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| University of Minnesota Physicians Bone Marrow Transplant Clinic | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Albert Einstein Medical Center, Cancer Center | Philadelphia | Pennsylvania | 19141 | — |
| Greenville Health System (GHS) Cancer Institute | Greenville | South Carolina | 29605 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390-9015 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Emily Couric Clinical Cancer Center | Charlottesville | Virginia | 22903 | — |
| Seattle Cancer Care Alliance (SCCA) | Seattle | Washington | 98109 | — |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | — |
| Marshfield Clinic - Marshfield Center | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 126 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02562443, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 26, 2022 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02562443 live on ClinicalTrials.gov.