A Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) With Pembrolizumab in Participants With Selected Hyaluronan High Solid Tumors
Public ClinicalTrials.gov record NCT02563548. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1B Open-Label Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) Combined With Pembrolizumab in Subjects With Selected Hyaluronan-High Solid Tumors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 1b study evaluating a combination of PEGPH20 and pembrolizumab in hyaluronan-high (HA-high) participants with relapsed/refractory non-small cell lung cancer (NSCLC) and HA-high participants with relapsed/refractory gastric adenocarcinoma (GAC).
Study identification
- NCT ID
- NCT02563548
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 56 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 22, 2015 (Actual)
- Primary completion
- Mar 26, 2019 (Actual)
- Completion
- Mar 26, 2019 (Actual)
- Last update posted
- Feb 7, 2020
2015 – 2019
United States locations
- U.S. sites
- 28
- U.S. states
- 19
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Mayo Clinic, Scottsdale, Arizona | Scottsdale | Arizona | 85259-5499 | — |
| California Cancer Associates for Research and Excellence - Encinitas | Encinitas | California | 92009 | — |
| University of California San Diego - Moores Cancer Center | La Jolla | California | 92093 | — |
| St. Joseph's Hospital | Orange | California | 92868 | — |
| University of California - Davis | Sacramento | California | 95817 | — |
| St. Joseph's Hospital | Santa Rosa | California | 95403 | — |
| Innovative Clinical Research | Whittier | California | 90603 | — |
| University of Colorado Denver University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Holy Cross Hospitals | Fort Lauderdale | Florida | 33308 | — |
| University of Miami/Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Cleveland Clinic Florida | Weston | Florida | — | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Johns Hopkins Kimmel Cancer Center | Baltimore | Maryland | 21231 | — |
| Barbara Ann Karmanos Cancer Center | Detroit | Michigan | 48201 | — |
| Washington University School of Medicine | St Louis | Missouri | 63130 | — |
| New Jersey Hematology Oncology Associates | Brick | New Jersey | 08724 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Gabrail Cancer Center | Canton | Ohio | 44718 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Mary Crowley Cancer Research Center | Dallas | Texas | 75251 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Swedish Health Services | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02563548, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 7, 2020 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02563548 live on ClinicalTrials.gov.