ClinicalTrials.gov record
Trial of Sacituzumab Govitecan in Participants With Refractory/Relapsed Metastatic Triple-Negative Breast Cancer (TNBC)
ClinicalTrials.gov ID: NCT02574455
Public ClinicalTrials.gov record NCT02574455. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An International, Multi-Center, Open-Label, Randomized, Phase III Trial of Sacituzumab Govitecan Versus Treatment of Physician Choice in Patients With Metastatic Triple-Negative Breast Cancer Who Received at Least Two Prior Treatments
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to compare the efficacy of sacituzumab govitecan to the treatment of physician's choice (TPC) as measured by independently-reviewed Independent Review Committee (IRC) progression-free survival (PFS) in participants with locally advanced or metastatic triple-negative breast cancer (TNBC) previously treated with at least two systemic chemotherapy regimens for unresectable, locally advanced or metastatic disease, and without brain metastasis at baseline.
Study identification
- NCT ID
- NCT02574455
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 529 participants
Conditions and interventions
Conditions
Interventions
- Sacituzumab govitecan Drug
- Eribulin Drug
- Capecitabine Drug
- Gemcitabine Drug
- Vinorelbine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 7, 2017 (Actual)
- Primary completion
- Mar 30, 2020 (Actual)
- Completion
- Dec 8, 2020 (Actual)
- Last update posted
- Jun 15, 2022
2017 – 2020
United States locations
- U.S. sites
- 185
- U.S. states
- 25
- U.S. cities
- 147
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center, 29653 Anchor Cross Blvd | Daphne | Alabama | 36526 | — |
| Souther Cancer Center, 3719 Dauphin St., 5 Floor | Mobile | Alabama | 36608 | — |
| Southern Cancer Center, 3 Mobile Infirmary Circle | Mobile | Alabama | 36608 | — |
| Southern Cancer Center, 6701 Airport Blvd., Bldg B, Terace Level | Mobile | Alabama | 36608 | — |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| Mayo Clinic Hospital | Scottsdale | Arizona | 85259 | — |
| UCLA Jonsson Comprehensive Cancer Center, 1411 S. Garfield Ave Suite 200 | Alhambra | California | 91801 | — |
| UCLA Jonsson Comprehensive Cancer Center, 201. S. Buena Vista St Suite 200 | Burbank | California | 91505 | — |
| UCLA Jonsson Comprehensive Cancer Center | Laguna Hills | California | 92653 | — |
| UCLA Jonsson Comprehensive Cancer Center, 200 UCLA Medical Plaza | Los Angeles | California | 90095 | — |
| UCLA Jonsson Comprehensive Cancer Center, 625 South Fair Oaks Avenue Suite 320 | Pasadena | California | 91105 | — |
| University of California, San Francisco (UCSF) - Innovation, Technology & Alliances, 1600 Divisadero Street | San Francisco | California | 94115 | — |
| UCLA Jonsson Comprehensive Cancer Center, 2020 Santa Monica Boulevard | Santa Monica | California | 94115 | — |
| Rocky Mountain Cancer Centers, 1700 South Potomac Street | Aurora | Colorado | 80012-5405 | — |
| University of Colorado Hospital - Anschutz Cancer Pavilion, 1665 Aurora Court | Aurora | Colorado | 80045 | — |
| Rocky Mountain Cancer Centers, 4715 Arapahoe Ave | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers, 2312 N. Nevada Avenue, Suite 400 | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers, 1800 Williams St. | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers, 4700 E. Hale Parkway, Suite 400 | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers, 499 E Hampden Ave Suite 450 | Englewood | Colorado | 80113 | — |
| Rocky Mountain Cancer Centers, 11750 West 2nd Place, Suite 1-100 | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers, 22 West Dry Creek Circle | Littleton | Colorado | 80120 | — |
| Rocky Mountain Cancer Centers, 10103 Ridge Gate Parkway, Suite G-01 | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers, 2030 W Mountain View Avenue, Ste. 210 | Longmont | Colorado | 80501 | — |
| Rocky Mountain Cancer Centers, 9397 Crown Crest Blvd., Suite 421 | Parker | Colorado | 80138 | — |
| Rocky Mountain Cancer Centers, 3676 Parker Blvd., Suite 350 | Pueblo | Colorado | 81008 | — |
| Rocky Mountain Cancer Centers, 8820 Huron Street | Thornton | Colorado | 80260 | — |
| Yale School Of Medicine | New Haven | Connecticut | 06510-3206 | — |
| Norwalk Hospital, 34 Maple Street | Norwalk | Connecticut | 06856 | — |
| Georgetown Lombardi Comprehensive Cancer Center | Washington D.C. | District of Columbia | 20007 | — |
| Florida Cancer Specialists & Research Institute, 601 E. Altamonte Drive | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialist | Bonita Springs | Florida | 34135 | — |
| Florida Cancer Specialists | Bradenton | Florida | 34209 | — |
| Florida Cancer Specialists & Research Institute, 403 S. King Ave | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists | Cape Coral | Florida | 33914 | — |
| Florida Cancer Specialists & Research Institute, 3280 McMullen Booth road | Clearwater | Florida | 33761 | — |
| Sylvester Comprehensive Cancer Center | Coral Gables | Florida | 33146 | — |
| Florida Cancer Specialists & Research Institute, 224 Memorial medical Parway | Daytona Beach | Florida | 32117 | — |
| Sylvester Comprehensive Cancer Center | Deerfield Beach | Florida | 33442 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33905 | — |
| Florida Cancer Specialists & Research Institute, 6420 W Newberry Road Est Wing | Gainesville | Florida | 32605 | — |
| Florida Cancer Specialists & Research Institute, 100 Highland Avenue | Largo | Florida | 33770 | — |
| Florida Cancer Specialists & Research Institute, 521 N. Lecanto Highway | Lecanto | Florida | 34461 | — |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| Baptist Health Medical Group Oncology, LLC | Miami | Florida | 33176 | — |
| Florida Cancer Specialists | Naples | Florida | 34102 | — |
| Florida Cancer Specialists & Research Institute, 8763 River Crossing Blvd | New Port Richey | Florida | 34655 | — |
| Florida Cancer Specialists & Research Institute, 1630 SE 18th ST | Ocala | Florida | 34471 | — |
| Florida Cancer Specialists & Research Institute, 765 Image Way | Orange City | Florida | 32763 | — |
| Orlando Regional Medical Center | Orlando | Florida | 32806-2008 | — |
| Florida Cancer Specialists & Research Institute, 70 W Gore Street | Orlando | Florida | 32806 | — |
| Florida Cancer Specialists & Research Institute - 325 Clyde Morris | Ormond Beach | Florida | 32774 | — |
| Sylvester Comprehensive Cancer Center | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists | Port Charlotte | Florida | 33980 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34236 | — |
| Florida Cancer Specialists & Research Institute, 7154 Medical Center Drive | Spring Hill | Florida | 34608 | — |
| Florida Cancer Specialists & Research Institute, 1201 Fifth Avenue North | St. Petersburg | Florida | 33705-1449 | — |
| Florida Cancer Specialists & Research Institute, 560 Jackson St | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists & Research Institute, 3402 W Dr. Martin Luther King Jr Boulevard | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists & Research Institute, 4100 Waterman Way | Tavares | Florida | 32778 | — |
| Florida Cancer Specialists & Research Institute, 1400 US highway 441 N | The Villages | Florida | 32159 | — |
| Florida Cancer Specialists | Venice | Florida | 34285 | — |
| Florida Cancer Specialists | Venice | Florida | 34292 | — |
| Florida Cancer Specialists & Research Institute - 3730 7th Terrace | Vero Beach | Florida | 32960 | — |
| Florida Cancer Specialists & Research Institute, 1037 State Road 7 Bldg B | Wellington | Florida | 98374 | — |
| Florida Cancer Specialists & Research Institute1309 N Flagler Dr | West Palm Beach | Florida | 33401-3406 | — |
| Florida Cancer Specialists & Research Institute, 2100 Glenwood Drive | Winter Park | Florida | 32792 | — |
| Atlanta Cancer Center - Alpharetta | Alpharetta | Georgia | 30005 | — |
| University Cancer & Blood Center, 3320 Old Jefferson Rd | Athens | Georgia | 30607 | — |
| GCS/Annex | Atlanta | Georgia | 30341 | — |
| Atlanta Cancer Care - Atlanta | Atlanta | Georgia | 30342 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| GCS/Canton | Canton | Georgia | 30114 | — |
| Atlanta Cancer Care - Conyers | Conyers | Georgia | 30094 | — |
| Atlanta Cancer Care - Cumming | Cumming | Georgia | 30041 | — |
| Atlanta Cancer Care - Decatur | Decatur | Georgia | 30033 | — |
| GCS/Stemmer | Decatur | Georgia | 30033 | — |
| Atlanta Cancer Care - Stockbridge | Jonesboro | Georgia | 30236 | — |
| GCS/Macon | Macon | Georgia | 31217 | — |
| GCS/Kennestone | Marietta | Georgia | 30060 | — |
| GCS/Northside | Sandy Springs | Georgia | 30342 | — |
| Illinois Cancer Specialists | Arlington Heights | Illinois | 60005 | — |
| University of Chicago Medical Center 5841 S. Maryland Ave | Chicago | Illinois | 60637 | — |
| University of Chicago Comprehensive Cancer Center at Silver Cross Hospital 1900 Silver Cross Blvd | New Lenox | Illinois | 60451 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714-5905 | — |
| Orland Park - UCMC Center for Advanced Care 14290 South LaGrange Rd | Orland Park | Illinois | 60462 | — |
| MidAmerica Division Inc. c/o Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care Pavilion | Westwood | Kansas | 66205-2005 | — |
| Maryland Oncology Hematology | Bethesda | Maryland | 20817 | — |
| Maryland Oncology Hematology | Brandywine | Maryland | 20613 | — |
| Maryland Oncology Hematology | Clinton | Maryland | 20735 | — |
| Maryland Oncology Hematology | Columbia | Maryland | 21044 | — |
| Maryland Oncology Hematology | Rockville | Maryland | 20850 | — |
| Maryland Oncology Hematology | Silver Spring | Maryland | 20902 | — |
| Maryland Oncology Hematology | Silver Spring | Maryland | 20904 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02114-2621 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center (BIDMC) | Boston | Massachusetts | 02215-5400 | — |
| Mass General - North Shore Cancer Center ( NSCC ) | Danvers | Massachusetts | 01923 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Minnesota Oncology Hematology P.A. | Coon Rapids | Minnesota | 55433 | — |
| Suburban Imaging Northwest | Coon Rapids | Minnesota | 55433 | — |
| Suburban Imaging | Coon Rapids | Minnesota | 55433 | — |
| Mercy Hospital - Unity Campus AHL | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology P.A. | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology P.A. | Minneapolis | Minnesota | 55404 | — |
| Abbot Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Virginia G. Piper Cancer Center at HonorHealth | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic - 200 First Street SW | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine in St. Louis | Creve Coeur | Missouri | 63141 | — |
| MidAmerica Division Inc. c/o Menorah Medical Center | Independence | Missouri | 64057 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Washington University School of Medicine in St. Louis | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine in St. Louis | St Louis | Missouri | 63129 | — |
| Washington University School of Medicine in St. Louis | St Louis | Missouri | 63136 | — |
| Nebraska Cancer Specialists - Midwest Cancer Center - Papillion | Omaha | Nebraska | 68114 | — |
| Nebraska Cancer Specialists - Midwest Cancer Center - Paillion | Omaha | Nebraska | 68130 | — |
| Nebraska Cancer Specialists- Midwest Cancer Center- Papillion | Papillion | Nebraska | 68046-5706 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| New York Oncology Hematology, P.C. | Albany | New York | 12206 | — |
| New York Oncology Hematology, P.C. | Clifton Park | New York | 12065 | — |
| North Shore Hematology Oncology Associates., PC, 235 North Belle Mead Road | East Setauket | New York | 11733 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| North Shore Hematology Oncology Associates., PC, 285 Sills Road Building 16 | Patchogue | New York | 11772 | — |
| UNC Health Care System | Chapel Hill | North Carolina | 27599 | — |
| The Ohio State University Wexner Medical Center, 460 W 10th Ave | Columbus | Ohio | 432100 | — |
| The Ohio State University Wexner Medical Center, 1145 Olentangy River Road | Columbus | Ohio | 43212 | — |
| Providence Medical Group | Portland | Oregon | 97213 | — |
| UPMC Hillman Cancer Center Mountainview Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| UPMC Hillman Cancer Center UPMC East | Monroeville | Pennsylvania | 15146 | — |
| UPMC Hillman Cancer Center Upper Saint Clair | Pittsburgh | Pennsylvania | 15102 | — |
| Allegheny-Singer Research Institute, 320 East North Avenue | Pittsburgh | Pennsylvania | 15212 | — |
| Magee-Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Hillman Cancer Center UPMC Passavant | Pittsburgh | Pennsylvania | 15237 | — |
| Tennessee Oncology - Chattanooga Oncology & Hematology Associates | Chattanooga | Tennessee | 37404-1108 | — |
| Tennesee Oncology - PLLC | Chattanooga | Tennessee | 37404 | — |
| Tenesse Oncology - PLLC | Cleveland | Tennessee | 37311 | — |
| Tennessee Oncology, LLC | Dickson | Tennessee | 37055 | — |
| Tennessee Ocology, LLC | Franklin | Tennessee | 37067 | — |
| Tennessee Oncology, LLC | Gallatin | Tennessee | 37066 | — |
| West Cancer Center, 7945 Wolf River Blvd | Germantown | Tennessee | 28138 | — |
| Tennessee Oncology, LLC | Hermitage | Tennessee | 37076 | — |
| Tennessee Oncology, LLC | Lebanon | Tennessee | 37090 | — |
| Tennessee Oncology, LLC | Murfreesboro | Tennessee | 37129 | — |
| Sarah Cannon Cancer Institute/Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, LLC | Nashville | Tennessee | 37203 | — |
| Vanderbilt Breast Cancer Center at One Hundred Oaks 719 Thompson Lane, Suite 25000 | Nashville | Tennessee | 37204 | — |
| Tennessee Ocology, LLC | Nashville | Tennessee | 37205 | — |
| Tennessee Oncology, LLC | Nashville | Tennessee | 37207 | — |
| Tenessee Oncology | Nashville | Tennessee | 37211 | — |
| Henry-Joyce Cancer Clinic 1301 Medical Center Drive 1903 The Vanderbilt Clinic Nashville, TN 37232 | Nashville | Tennessee | 37232 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Tennessee Oncology, LLC | Shelbyville | Tennessee | 37160 | — |
| Center for Cancer and Blood Disorders | Arlington | Texas | 76014 | — |
| Center for Cancer and Blood Disorders | Burleson | Texas | 76028 | — |
| Texas Oncology- Medical City Dallas Building D | Dallas | Texas | 75230-6899 | — |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246-2006 | — |
| Texas Oncology | Denton | Texas | 76210 | — |
| Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104-4611 | — |
| Houston Methodist Hospital - 6565 Fannin St | Houston | Texas | 77030 | — |
| Texas Oncology-Longview Cancer Center | Longview | Texas | 75601 | — |
| Texas Oncology | Plano | Texas | 75075-7753 | — |
| US Oncology | Tyler | Texas | 75702 | — |
| Center for Cancer and Blood Disorders | Weatherford | Texas | 76086 | — |
| Virginia Cancer Specialists, PC | Alexandria | Virginia | 22304 | — |
| Virginia Cancer Specialists, PC | Arlington | Virginia | 22205 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | — |
| Virginia Oncology Associates | Chesapeake | Virginia | 23320 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031-4629 | — |
| Virginia Cancer Specialists, PC | Gainesville | Virginia | 20155 | — |
| Virginia Oncology Associates | Hampton | Virginia | 23666 | — |
| Virginia Cancer Specialists, PC | Leesburg | Virginia | 20176 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | — |
| Virginia Oncology Associates | Newport News | Virginia | 23606 | — |
| Virginia Oncology Associates, P.C. | Norfolk | Virginia | 23502-0026 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | — |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Salem | Virginia | 24153 | — |
| Virginia Oncology Associates | Virginia Beach | Virginia | 23456 | — |
| Virginia Cancer Specialists, PC | Woodbridge | Virginia | 22191 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | — |
| Swedish Cancer Institute | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute | Issaquah | Washington | 98029 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| Swedish Cancer Institute | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02574455, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 15, 2022 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02574455 live on ClinicalTrials.gov.