Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)
Public ClinicalTrials.gov record NCT02580591. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomised, Double Blind, Placebo-controlled, Parallel Group, Efficacy, Safety and Tolerability Trial of Once Daily, Oral Doses of Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With Type 1 Diabetes Mellitus (EASE-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study will investigate the efficacy, safety, tolerability and Pharmacokinetic(PK) of 3 doses of empagliflozin compared with placebo over 26 weeks in 960 patients with type 1 diabetes mellitus as adjunctive therapy to insulin
Study identification
- NCT ID
- NCT02580591
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 977 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 22, 2015 (Actual)
- Primary completion
- Sep 12, 2017 (Actual)
- Completion
- Sep 20, 2017 (Actual)
- Last update posted
- Nov 2, 2018
2015 – 2017
United States locations
- U.S. sites
- 39
- U.S. states
- 18
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Healthscan Clinical Trials LLC | Montgomery | Alabama | 36106 | — |
| John Muir Physician Network Clinical Research Center | Concord | California | 94520 | — |
| Valley Research | Fresno | California | 93720 | — |
| Marin Endocrine Care and Research | Greenbrae | California | 94904 | — |
| Pacific Research Partners, LLC | Oakland | California | 94607 | — |
| NorCal Endocrinology and Internal Medicine | San Ramon | California | 94583 | — |
| William Sansum Diabetes Center | Santa Barbara | California | 93105 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| International Research Associates, LLC | Hialeah | Florida | 33012 | — |
| Solutions Through Advanced Research, Inc. | Jacksonville | Florida | 32225 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Physicians Research Associates, LLC | Lawrenceville | Georgia | 30046 | — |
| Sestron Clinical Research | Marietta | Georgia | 30060 | — |
| Eagle's Landing Diabetes and Endocrinology | Stockbridge | Georgia | 30281 | — |
| Northwest Endo Diabetes Research, LLC | Arlington Heights | Illinois | 60005 | — |
| Kentucky Diabetes Endocrinology Center | Lexington | Kentucky | 40503 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| MODEL Clinical Research | Baltimore | Maryland | 21204 | — |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | — |
| Desert Endocrinology Clinical Research Center | Henderson | Nevada | 89052 | — |
| Palm Research Center | Las Vegas | Nevada | 89128 | — |
| Endocrine-Diabetes Care and Resource Center | Rochester | New York | 14607 | — |
| Endocrine Associates of Long Island, PC | Smithtown | New York | 11787 | — |
| Diabetes Endocrinology Research Center of Western New York | Williamsville | New York | 14221 | — |
| Diabetes and Endocrinology Consultants, PC | Morehead City | North Carolina | 28557 | — |
| Holzer Clinic LLC | Gallipolis | Ohio | 45631 | — |
| COR Clinical Research, LLC | Oklahoma City | Oklahoma | 73103 | — |
| Strand Physician Specialists dba Carolina Health Specialists | Myrtle Beach | South Carolina | 29572 | — |
| AM Diabetes and Endocrinology Center | Bartlett | Tennessee | 38133 | — |
| Holston Medical Group | Bristol | Tennessee | 37620 | — |
| University Diabetes and Endocrine Consultants | Chattanooga | Tennessee | 37411 | — |
| Texas Diabetes & Endocrinology PA | Austin | Texas | 78749 | — |
| Texas Health Physicians Group | Dallas | Texas | 75218 | — |
| Dallas Diabetes and Endocrine Center | Dallas | Texas | 75230 | — |
| Research Institute of Dallas | Dallas | Texas | 75231 | — |
| Endeavor Clinical Trials, PA | San Antonio | Texas | 78229 | — |
| Virginia Endocrinology Research | Chesapeake | Virginia | 23321 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 150 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02580591, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 2, 2018 · Synced Oct 16, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02580591 live on ClinicalTrials.gov.