Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)

ClinicalTrials.gov ID: NCT02597127

Public ClinicalTrials.gov record NCT02597127. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 10:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Placebo-controlled, Double-blind, Randomized Trial to Compare the Effect of Different Doses of ALN-PCSSC Given as Single or Multiple Subcutaneous Injections in Subjects With High Cardiovascular Risk and Elevated LDL-C

Study identification

NCT ID: NCT02597127
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2
Lead sponsor: The Medicines Company; Industry
Enrollment: 501 participants

Conditions and interventions

Conditions

Interventions

ALN-PCSSC Drug
Normal Saline Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 99 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 31, 2015
Primary completion: Jun 6, 2017
Completion: Jun 6, 2017
Last update posted: May 16, 2019

2016 – 2017

United States locations

U.S. sites: 8
U.S. states: 7
U.S. cities: 7

Facility	City	State	ZIP	Site status
Jacksonville Center for Clinical Research	Jacksonville	Florida	32216	—
Midwest Institute For Clinical Research	Indianapolis	Indiana	46260	—
Mount Sinai Icahn School of Medicine	New York	New York	10029	—
Metabolic And Atherosclerosis Research Center	Cincinnati	Ohio	45227	—
Sterling Research Group	Cincinnati	Ohio	45246	—
Wellmont CVA Heart Institute	Greeneville	Tennessee	37745	—
Amarillo Heart Clinical Research Institute, Inc.	Amarillo	Texas	79106	—
National Clinical Research, Inc.	Richmond	Virginia	23294	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02597127, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 16, 2019 · Synced Jul 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT02597127 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →