ClinicalTrials.gov record
Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension
ClinicalTrials.gov ID: NCT02603809
Public ClinicalTrials.gov record NCT02603809. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-center, Double-blind, Double-dummy, Randomized, Placebo- and Active-reference, Parallel Group, Phase 2, Dose-finding Study With ACT-132577 in Subjects With Essential Hypertension (Grade 1 and 2).
Study identification
- NCT ID
- NCT02603809
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Idorsia Pharmaceuticals Ltd.
- Industry
- Enrollment
- 1,659 participants
Conditions and interventions
Conditions
Interventions
- Aprocitentan 10 mg Drug
- Aprocitentan 25 mg Drug
- Aprocitentan 5 mg Drug
- Aprocitentan 50 mg Drug
- Lisinopril 20 mg Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 13, 2015
- Primary completion
- Feb 27, 2017
- Completion
- Apr 6, 2017
- Last update posted
- Nov 22, 2022
2015 – 2017
United States locations
- U.S. sites
- 74
- U.S. states
- 27
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Appalachian Cardiovascular Associates | Fort Payne | Alabama | 35967 | — |
| Radiant Research Inc | Chandler | Arizona | 85224 | — |
| Warner Family Practice / Radiant Research Inc | Chandler | Arizona | 85224 | — |
| Phoenix Medical Research Institute LLC | Peoria | Arizona | 85381 | — |
| Advanced Arizona Clinical Research | Tucson | Arizona | 85704 | — |
| Noble Clinical Research LLC | Tucson | Arizona | 85704 | — |
| Desert Sun Clinical Research LLc | Tucson | Arizona | 85710 | — |
| Advanced Research Center Inc | Anaheim | California | 92805 | — |
| Med Center | Carmichael | California | 95608 | — |
| John Muir Physician Network Clinical Research Center | Concord | California | 94520 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Long Beach Center for Clinical Research | Long Beach | California | 90807 | — |
| Entertainment Medical Group Inc | Los Angeles | California | 90036 | — |
| Artemis institute for Clinical Research | San Diego | California | 92103 | — |
| Memorial Research Medical Clinic / Orange County Research Center | Tustin | California | 92780 | — |
| Empire Clinical Research | Upland | California | 91786 | — |
| Clinical Research Consulting LLC | Milford | Connecticut | 06460 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| Alfieri Cardiology | Wilmington | Delaware | 19803 | — |
| ACRC - Cardiology | Atlantis | Florida | 33462 | — |
| Innovative Research of West Florida INC | Clearwater | Florida | 33756 | — |
| Avail Clinical Research LLC | DeLand | Florida | 32720 | — |
| Alan Graff, MD, PA | Fort Lauderdale | Florida | 33308 | — |
| Gulfcoast Clinical Research Center | Fort Myers | Florida | 33912 | — |
| AGA Clinical Trials | Hialeah | Florida | 33012 | — |
| Canvas Clinical Research, LLC | Lake Worth | Florida | 33467 | — |
| LCC Medical Research Institute | Miami | Florida | 33126 | — |
| Allied Biomedical Research Institute, INC | Miami | Florida | 33155 | — |
| Southeast Regional Research Group | Savannah | Georgia | 31401 | — |
| Community Clin Res CTR | Anderson | Indiana | 46011 | — |
| Midwest Institute for Clinical Research | Indianapolis | Indiana | 46260 | — |
| Heartland Research Associated LLC | Newton | Kansas | 67114 | — |
| Heartland Research Associates LLC | Wichita | Kansas | 67205 | — |
| Heartland Research Associates LLC | Wichita | Kansas | 67207 | — |
| Avant Research Associates, LLC | Crowley | Louisiana | 70526 | — |
| Best Clinical Trials LLC | New Orleans | Louisiana | 70115 | — |
| New Orleans Center for Clinical Research - Nola | New Orleans | Louisiana | 70119 | — |
| Clinsite LLC | Ann Arbor | Michigan | 48106 | — |
| Primecare Research Associates, LLC | Florissant | Missouri | 63031 | — |
| Clinical Research Advantage, Inc. / Diagnostic Center Of Medicine - Durango | Las Vegas | Nevada | 89117 | — |
| Premier Research | Trenton | New Jersey | 08611 | — |
| Rochester Clinical Research Inc. | Rochester | New York | 14609 | — |
| Metrolina Internal Medicine/Internal Medicine Research | Charlotte | North Carolina | 28204 | — |
| Pharmquest LLC | Greensboro | North Carolina | 27408 | — |
| Peters Medical Research | High Point | North Carolina | 27262 | — |
| Wake Research Associates | Raleigh | North Carolina | 27604-1547 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58103 | — |
| Sterling Research Group Ltd. | Cincinnati | Ohio | 45219 | — |
| Aventiv Research Inc. | Columbus | Ohio | 43213 | — |
| Dayton Clinical Research | Dayton | Ohio | 45406 | — |
| Aventiv Research Inc. | Dublin | Ohio | 43016 | — |
| Oklahoma City Clinic - Edmond / Radiant Research Inc | Edmond | Oklahoma | 73034 | — |
| Clinical Research Advantage, Inc. / Oklahoma City Clinic - Midwest City | Midwest City | Oklahoma | 73110 | — |
| Willamette Valley Clinical Studies | Eugene | Oregon | 97404 | — |
| Detweiler Family Medicine and Associates PC | Lansdale | Pennsylvania | 19446 | — |
| Suburban Research Center | Media | Pennsylvania | 19063 | — |
| Degarmo Institute of Medical Research | Greer | South Carolina | 29651 | — |
| Volunteer Research Group | Knoxville | Tennessee | 37920 | — |
| Tekton Research Inc | Austin | Texas | 78745 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78749 | — |
| Trinity Hypertension & Metabolic Research Institute | Carrollton | Texas | 75006 | — |
| Family Medicine Associates of Texas - ACRC Trials | Carrollton | Texas | 75010 | — |
| Coastal Bend Clinical Research | Corpus Christi | Texas | 78413 | — |
| TR - Global Medical Research | DeSoto | Texas | 75115 | — |
| Ventavia Research Group, LLC | Fort Worth | Texas | 76104 | — |
| Clinical Investigations of Texas | Plano | Texas | 75075 | — |
| Avant Research Associates LLC | Port Arthur | Texas | 77640 | — |
| Texas Diabetes & Endocrinology | Round Rock | Texas | 78681 | — |
| Radiant Research Inc | San Antonio | Texas | 78229 | — |
| Bandera Family Health Care | San Antonio | Texas | 78249 | — |
| Wasatch Clinical Research LLC | Salt Lake City | Utah | 84107 | — |
| Health Research of Hampton Roads | Newport News | Virginia | 23606 | — |
| National Clinical Research Inc | Richmond | Virginia | 23294 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02603809, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 22, 2022 · Synced Apr 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02603809 live on ClinicalTrials.gov.