An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML) and Low-Blast Acute Myelogenous Leukemia (AML)
Public ClinicalTrials.gov record NCT02610777. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Controlled, Open-Label, Clinical Study of the Efficacy and Safety of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Patients With Higher-Risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia and Low-Blast Acute Myelogenous Leukemia
Study identification
- NCT ID
- NCT02610777
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Millennium Pharmaceuticals, Inc.
- Industry
- Enrollment
- 120 participants
Conditions and interventions
Interventions
- Azacitidine Drug
- Pevonedistat Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 13, 2016
- Primary completion
- Sep 3, 2019
- Completion
- Jul 22, 2021
- Last update posted
- Sep 18, 2022
2016 – 2021
United States locations
- U.S. sites
- 23
- U.S. states
- 15
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35233 | — |
| Greenville Health System | Little Rock | Arkansas | 72201 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Compassionate Cancer Care Medical Group Incorporated | Riverside | California | 92501 | — |
| Rocky Mountain Cancer Centers | Aurora | Colorado | 80012 | — |
| Smilow Cancer Center at Yale New Haven Hospital | New Haven | Connecticut | 06510 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| H Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | — |
| Monter Cancer Center | Lake Success | New York | 11042 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14603 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Cancer Care Center of South Texas | New Braunfels | Texas | 78130 | — |
| Nebraska Cancer Specialists | The Woodlands | Texas | 77380 | — |
| Texas Oncology - Waco, TX | Tyler | Texas | 76712 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
| Medical Oncology Associates | Spokane | Washington | 99208 | — |
| Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 36 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02610777, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 18, 2022 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02610777 live on ClinicalTrials.gov.