Study to Evaluate Safety and Pharmacokinetics of GS-4059 (Tirabrutinib) in Healthy Volunteers and Participants With Rheumatoid Arthritis (RA)
Public ClinicalTrials.gov record NCT02626026. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1, Placebo-Controlled, Randomized Study Evaluating the Safety and Pharmacokinetics of GS-4059 in Healthy Volunteers and Subjects With Rheumatoid Arthritis (RA)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will consist of two parts: Part A will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of tirabrutinib in healthy participants. Part B will evaluate the safety, tolerability, and the effect of tirabrutinib on disease-specific clinical markers and outcomes in participants with rheumatoid arthritis (RA).
Study identification
- NCT ID
- NCT02626026
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 42 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 26, 2016 (Actual)
- Primary completion
- Sep 1, 2016 (Actual)
- Completion
- Sep 1, 2016 (Actual)
- Last update posted
- Sep 9, 2020
2016
United States locations
- U.S. sites
- 9
- U.S. states
- 6
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UC Davis Lawrence J. Ellison | Sacramento | California | 95817 | — |
| SeaView Research, Inc. | Miami | Florida | 33126 | — |
| Omega Research Consultants, LLC | Orlando | Florida | 32804 | — |
| Lovelace Scientific Resources, Inc. | Venice | Florida | 34292 | — |
| Center for Arthritis & Osteoporosis | Elizabethtown | Kentucky | 42701 | — |
| Justus J. Fiechtner, M.D., P.C. | Lansing | Michigan | 48910 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Clinical Research Center of Reading, LLC | Wyomissing | Pennsylvania | 19610 | — |
| Arthritis & Osteoporosis Center of South Texas | San Antonio | Texas | 78232 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02626026, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 9, 2020 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02626026 live on ClinicalTrials.gov.