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ClinicalTrials.gov record
Completed Phase 2Phase 3 Interventional Results available

Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer

ClinicalTrials.gov ID: NCT02635009

Public ClinicalTrials.gov record NCT02635009. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 20, 2026, 12:38 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only (limited stage) or has spread outside of the lung in which it began or to other parts of the body (extensive stage). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. The hippocampus is part of the brain that is important for memory. Avoiding the hippocampus during whole-brain radiation could decrease the chance of side effects on memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more effective with or without hippocampal avoidance in treating patients with small cell lung cancer.

Study identification

NCT ID
NCT02635009
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2, Phase 3
Lead sponsor
NRG Oncology
Other
Enrollment
418 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 22, 2015 (Actual)
Primary completion
May 18, 2023 (Actual)
Completion
Sep 4, 2025 (Actual)
Last update posted
Jul 10, 2026

2015 – 2025

United States locations

U.S. sites
270
U.S. states
43
U.S. cities
220
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 —
Lewis and Faye Manderson Cancer Center Tuscaloosa Alabama 35401 —
Banner University Medical Center - Tucson Tucson Arizona 85719 —
Marin General Hospital Greenbrae California 94904 —
Los Angeles General Medical Center Los Angeles California 90033 —
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 —
Mercy Cancer Center Merced California 95340 —
Kaiser Permanente Oakland-Broadway Oakland California 94611 —
Saint Joseph Hospital - Orange Orange California 92868 —
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California 95670 —
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California 95661 —
The Permanente Medical Group-Roseville Radiation Oncology Roseville California 95678 —
Sutter Medical Center Sacramento Sacramento California 95816 —
University of California Davis Comprehensive Cancer Center Sacramento California 95817 —
California Pacific Medical Center-Pacific Campus San Francisco California 94115 —
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051 —
Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee California 96161 —
Sutter Solano Medical Center/Cancer Center Vallejo California 94589 —
Swedish Medical Center Englewood Colorado 80113 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Hartford HealthCare - Saint Vincent's Medical Center Bridgeport Connecticut 06606 —
Yale University New Haven Connecticut 06520 —
Helen F Graham Cancer Center Newark Delaware 19713 —
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 —
Boca Raton Regional Hospital Boca Raton Florida 33486 —
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 —
Broward Health Medical Center Fort Lauderdale Florida 33316 —
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 —
Miami Cancer Institute Miami Florida 33176 —
Orlando Health Cancer Institute Orlando Florida 32806 —
Moffitt Cancer Center Tampa Florida 33612 —
Grady Health System Atlanta Georgia 30303 —
Emory University Hospital Midtown Atlanta Georgia 30308 —
Piedmont Hospital Atlanta Georgia 30309 —
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 —
Northside Hospital Atlanta Georgia 30342 —
Northside Hospital-Forsyth Cumming Georgia 30041 —
Memorial Health University Medical Center Savannah Georgia 31404 —
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia 31405 —
Queen's Medical Center Honolulu Hawaii 96813 —
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817 —
The Cancer Center of Hawaii-Pali Momi ‘Aiea Hawaii 96701 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 —
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 —
Northwestern University Chicago Illinois 60611 —
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612 —
Rush MD Anderson Cancer Center Chicago Illinois 60612 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Crossroads Cancer Center Effingham Illinois 62401 —
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 —
Edward Hines Jr VA Hospital Hines Illinois 60141 —
Condell Memorial Hospital Libertyville Illinois 60048 —
Loyola University Medical Center Maywood Illinois 60153 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Methodist Medical Center of Illinois Peoria Illinois 61636 —
OSF Saint Francis Medical Center Peoria Illinois 61637 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 —
Ascension Saint Vincent Anderson Anderson Indiana 46016 —
Parkview Hospital Randallia Fort Wayne Indiana 46805 —
Parkview Regional Medical Center Fort Wayne Indiana 46845 —
Goshen Center for Cancer Care Goshen Indiana 46526 —
IU Health Ball Memorial Hospital Muncie Indiana 47303 —
Saint Luke's Hospital Cedar Rapids Iowa 52402 —
Mercy Hospital Cedar Rapids Iowa 52403 —
Iowa Methodist Medical Center Des Moines Iowa 50309 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 —
Ascension Via Christi Hospitals Wichita Wichita Kansas 67214 —
Wesley Medical Center Wichita Kansas 67214 —
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 —
Tulane University School of Medicine New Orleans Louisiana 70112 —
Luminis Health Anne Arundel Medical Center Annapolis Maryland 21401 —
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201 —
MedStar Franklin Square Medical Center/Weinberg Cancer Institute Baltimore Maryland 21237 —
MedStar Good Samaritan Hospital Baltimore Maryland 21239 —
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 —
UM Upper Chesapeake Medical Center Bel Air Maryland 21014 —
Central Maryland Radiation Oncology in Howard County Columbia Maryland 21044 —
UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie Maryland 21061 —
TidalHealth Richard A Henson Cancer Institute Ocean Pines Maryland 21811 —
TidalHealth Peninsula Regional Salisbury Maryland 21801 —
UM Saint Joseph Medical Center Towson Maryland 21204 —
Lahey Hospital and Medical Center Burlington Massachusetts 01805 —
Lowell General Hospital Lowell Massachusetts 01854 —
UMass Memorial Medical Center - University Campus Worcester Massachusetts 01655 —
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 —
McLaren Cancer Institute-Bay City Bay City Michigan 48706 —
Trinity Health Medical Center - Brighton Brighton Michigan 48114 —
Henry Ford Cancer Institute-Downriver Brownstown Michigan 48183 —
Chelsea Hospital Chelsea Michigan 48118 —
McLaren Cancer Institute-Clarkston Clarkston Michigan 48346 —
Michigan Healthcare Professionals Clarkston Clarkston Michigan 48346 —
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 —
Corewell Health Dearborn Hospital Dearborn Michigan 48124 —
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 —
Henry Ford Hospital Detroit Michigan 48202 —
Michigan Healthcare Professionals Farmington Farmington Hills Michigan 48334 —
Genesys Hurley Cancer Institute Flint Michigan 48503 —
McLaren Cancer Institute-Flint Flint Michigan 48532 —
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 —
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
McLaren Cancer Institute-Lapeer Region Lapeer Michigan 48446 —
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 —
Michigan Healthcare Professionals Macomb Macomb Michigan 48044 —
McLaren Cancer Institute-Macomb Mount Clemens Michigan 48043 —
McLaren Cancer Institute-Central Michigan Mount Pleasant Michigan 48858 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
McLaren Cancer Institute-Owosso Owosso Michigan 48867 —
McLaren Cancer Institute-Northern Michigan Petoskey Michigan 49770 —
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 —
McLaren-Port Huron Port Huron Michigan 48060 —
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073 —
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph Michigan 49085 —
Corewell Health Beaumont Troy Hospital Troy Michigan 48085 —
Michigan Healthcare Professionals Troy Troy Michigan 48098 —
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 —
Mayo Clinic Health System in Albert Lea Albert Lea Minnesota 56007 —
Saint Luke's Hospital of Duluth Duluth Minnesota 55805 —
Mayo Clinic Health Systems-Mankato Mankato Minnesota 56001 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
Mayo Clinic Radiation Therapy-Northfield Northfield Minnesota 55057 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
Freeman Health System Joplin Missouri 64804 —
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111 —
North Kansas City Hospital Kansas City Missouri 64116 —
University of Kansas Cancer Center - North Kansas City Missouri 64154 —
University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri 64116 —
Washington University School of Medicine St Louis Missouri 63110 —
Siteman Cancer Center-South County St Louis Missouri 63129 —
Missouri Baptist Medical Center St Louis Missouri 63131 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
Billings Clinic Cancer Center Billings Montana 59101 —
Benefis Sletten Cancer Institute Great Falls Montana 59405 —
Community Medical Center Missoula Montana 59804 —
University of Nebraska Medical Center Omaha Nebraska 68198 —
Renown Regional Medical Center Reno Nevada 89502 —
Wentworth-Douglass Hospital Dover New Hampshire 03820 —
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 —
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 —
Englewood Hospital and Medical Center Englewood New Jersey 07631 —
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 —
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 —
Virtua Memorial Mount Holly New Jersey 08060 —
Virtua Voorhees Voorhees Township New Jersey 08043 —
University of New Mexico Cancer Center Albuquerque New Mexico 87106 —
Northwell Health Imbert Cancer Center Bay Shore New York 11706 —
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215 —
Roswell Park Cancer Institute Buffalo New York 14263 —
Memorial Sloan Kettering Commack Commack New York 11725 —
Arnot Ogden Medical Center/Falck Cancer Center Elmira New York 14905 —
Memorial Sloan Kettering Westchester Harrison New York 10604 —
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 —
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032 —
Memorial Sloan Kettering Cancer Center New York New York 10065 —
Lenox Hill Hospital New York New York 10075 —
University of Rochester Rochester New York 14642 —
Staten Island University Hospital Staten Island New York 10305 —
State University of New York Upstate Medical University Syracuse New York 13210 —
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 —
Montefiore Medical Center - Moses Campus The Bronx New York 10467 —
Memorial Sloan Kettering Nassau Uniondale New York 11553 —
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203 —
Atrium Health Pineville/LCI-Pineville Charlotte North Carolina 28210 —
Atrium Health University City/LCI-University Charlotte North Carolina 28262 —
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025 —
Atrium Health Union/LCI-Union Monroe North Carolina 28112 —
Atrium Health Cleveland/LCI-Cleveland Shelby North Carolina 28150 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
Summa Health System - Akron Campus Akron Ohio 44304 —
Cleveland Clinic Akron General Akron Ohio 44307 —
Geauga Hospital Chardon Ohio 44024 —
Adena Regional Medical Center Chillicothe Ohio 45601 —
Case Western Reserve University Cleveland Ohio 44106 —
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Mount Carmel Health Center West Columbus Ohio 43222 —
Dayton Physician LLC - Englewood Dayton Ohio 45415 —
Mercy Cancer Center-Elyria Elyria Ohio 44035 —
Cleveland Clinic Cancer Center Independence Independence Ohio 44131 —
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 —
UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights Ohio 44130 —
University Hospitals Parma Medical Center Parma Ohio 44129 —
Cleveland Clinic Cancer Center Strongsville Strongsville Ohio 44136 —
UHHS-Westlake Medical Center Westlake Ohio 44145 —
Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio 44691 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Legacy Mount Hood Medical Center Gresham Oregon 97030 —
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 —
Jefferson Abington Hospital Abington Pennsylvania 19001 —
Crozer-Keystone Regional Cancer Center at Broomall Broomall Pennsylvania 19008 —
Bryn Mawr Hospital Bryn Mawr Pennsylvania 19010 —
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Northeast Radiation Oncology Center Dunmore Pennsylvania 18512 —
Adams Cancer Center Gettysburg Pennsylvania 17325 —
Crozer Regional Cancer Center at Brinton Lake Glen Mills Pennsylvania 19342 —
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 —
Riddle Memorial Hospital Media Pennsylvania 19063 —
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 —
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 —
Jefferson Torresdale Hospital Philadelphia Pennsylvania 19114 —
Temple University Hospital Philadelphia Pennsylvania 19140 —
Penn State Health Saint Joseph Medical Center Reading Pennsylvania 19605 —
Reading Hospital West Reading Pennsylvania 19611 —
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 —
Lankenau Medical Center Wynnewood Pennsylvania 19096 —
WellSpan Health-York Cancer Center York Pennsylvania 17403 —
AnMed Health Cancer Center Anderson South Carolina 29621 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Self Regional Healthcare Greenwood South Carolina 29646 —
The Radiation Oncology Center-Hilton Head/Bluffton Hilton Head Island South Carolina 29926 —
Lancaster Radiation Therapy Center Lancaster South Carolina 29720 —
Rock Hill Radiation Therapy Center Rock Hill South Carolina 29730 —
Rapid City Regional Hospital Rapid City South Dakota 57701 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
Covenant Health Cancer Centers Knoxville Tennessee 37916 —
Blount Memorial Hospital Maryville Tennessee 37804 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
University of Texas Medical Branch Galveston Texas 77555-0565 —
UT MD Anderson Cancer Center Houston Texas 77030 —
UTMB Cancer Center at Victory Lakes League City Texas 77573 —
Ogden Regional Medical Center Ogden Utah 84405 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
Central Vermont Medical Center/National Life Cancer Treatment Berlin Corners Vermont 05602 —
University of Vermont Medical Center Burlington Vermont 05401 —
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
Wheeling Hospital/Schiffler Cancer Center Wheeling West Virginia 26003 —
Langlade Hospital and Cancer Center Antigo Wisconsin 54409 —
Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield Wisconsin 53045 —
Mayo Clinic Health System-Eau Claire Clinic Eau Claire Wisconsin 54701 —
Mayo Clinic Health System Eau Claire Hospital-Luther Campus Eau Claire Wisconsin 54703 —
Ascension Saint Francis - Reiman Cancer Center Franklin Wisconsin 53132 —
Aurora Cancer Care-Grafton Grafton Wisconsin 53024 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek Wisconsin 53038 —
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
Mayo Clinic Health System-Franciscan Healthcare La Crosse Wisconsin 54601 —
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 —
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 —
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Aurora Sinai Medical Center Milwaukee Wisconsin 53233 —
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904 —
Ascension All Saints Hospital Racine Wisconsin 53405 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241 —
Aspirus Regional Cancer Center Wausau Wisconsin 54401 —
Aurora West Allis Medical Center West Allis Wisconsin 53227 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin 54494 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02635009, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 10, 2026 · Synced Oct 20, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02635009 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →