A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
Public ClinicalTrials.gov record NCT02637856. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients With Relapsing Remitting Multiple Sclerosis Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy and safety of ocrelizumab in participants with RRMS who have had a suboptimal response to an adequate course of DMT. Participants will receive ocrelizumab as an initial dose of two 300-milligrams (mg) intravenous (IV) infusions (600 mg total) separated by 14 days followed by one 600-mg IV infusion for a maximum of 4 doses (up to 96 weeks). Anticipated time on study treatment is 96 weeks.
Study identification
- NCT ID
- NCT02637856
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 608 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 11, 2016 (Actual)
- Primary completion
- May 3, 2019 (Actual)
- Completion
- May 3, 2019 (Actual)
- Last update posted
- May 26, 2020
2016 – 2019
United States locations
- U.S. sites
- 67
- U.S. states
- 29
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Central Neurology Associates | Cullman | Alabama | 35058 | — |
| Phoenix Neurological Associates Ltd | Phoenix | Arizona | 85006 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| Territory Neurology and Research Institute | Tucson | Arizona | 85704 | — |
| The Research Center of Southern California, LLC | Carlsbad | California | 92011 | — |
| Mercy Medical Group; MS Centre Nurse | Carmichael | California | 95608 | — |
| Fullerton Neurology and Headache Center | Fullerton | California | 92835 | — |
| Scripps Health | La Jolla | California | 92037 | — |
| UCSF- Multiple Sclerosis Centre; Department of Neurology | San Francisco | California | CA94158 | — |
| Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Mountain Neurological Research Center; Roaring Fork Neurologt, P.C. | Basalt | Colorado | 81621 | — |
| IMMUNOe Research Centers | Centennial | Colorado | 80112 | — |
| Colorado Neurological Institute | Englewood | Colorado | 80113 | — |
| Advanced Neurology of Colorado, LLC | Fort Collins | Colorado | 80528 | — |
| Associated Neurologists of Southern CT PC | Fairfield | Connecticut | 06824 | — |
| KI Health Partners, LLC; New England Institute for Clinical Research | Stamford | Connecticut | 06905 | — |
| Neurology Associates PA | Maitland | Florida | 32751 | — |
| University of Miami Miller School of Medicine; Clinical Reseach Building | Miami | Florida | 33136 | — |
| Neurostudies Inc | Port Charlotte | Florida | 33952 | — |
| Infinity Clinical Research, LLC | Sunrise | Florida | 33351 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| University of South Florida - Bradenton | Tampa | Florida | 33612 | — |
| Ms Center Of Atlanta | Atlanta | Georgia | 30327 | — |
| University of Chicago Hospital | Chicago | Illinois | 60637 | — |
| Consultants in Neurology Ltd | Northbrook | Illinois | 60062 | — |
| American Health Network Institute, LLC | Avon | Indiana | 46123 | — |
| Josephson Wallack Munshower Neurology PC | Indianapolis | Indiana | 46256 | — |
| University of Kansas Medical Center; Division of Nuclear Medicine | Kansas City | Kansas | 66160 | — |
| Lahey Clinic Med Ctr | Lexington | Kentucky | 02421 | — |
| Associates in Neurology PSC | Lexington | Kentucky | 40513 | — |
| Community Medical Associates Inc.; d.b.a. Norton Neurology Services MS Services | Louisville | Kentucky | 40207 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| University of Maryland Medical Center; Department of Neurology | Baltimore | Maryland | 21201 | — |
| John Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Med Ctr; Neurology/MS Center | Boston | Massachusetts | 02215 | — |
| Dragonfly Research, LLC | Wellesley | Massachusetts | 02481 | — |
| UMASS Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Wayne State University; Department of Neurology | Detroit | Michigan | 48201 | — |
| Minneapolis Clinic of Neurology | Golden Valley | Minnesota | 55422 | — |
| Washington University School of Medicine; Department of Neurology | St Louis | Missouri | 63110 | — |
| Cleveland Clinic Lou Ruvo; Center for Brain Research | Las Vegas | Nevada | 89106 | — |
| Rutgers New Jersey Medical School | Newark | New Jersey | 07103 | — |
| Holy Name Hospital; Institute For Clinical Research | Teaneck | New Jersey | 07666 | — |
| Jacobs Neurological Institute | Buffalo | New York | 14203 | — |
| The MS Center of Northeastern New York | Latham | New York | 12110 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| South Shore Neurologic Associates P.C. | Patchogue | New York | 11772 | — |
| Island Neurological Associates, P.C. | Plainview | New York | 11803 | — |
| Raleigh Neurology Associates | Raleigh | North Carolina | 27607-6520 | — |
| UC Health Clinical Trials Office | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic Foundation; Cleveland Clinic Cancer Center/I40 | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center; Department of Neurology | Columbus | Ohio | 43210 | — |
| Neurology Specialists, Inc | Dayton | Ohio | 45417 | — |
| Neurology and Neuroscience Assoc., Inc. | Westerville | Ohio | 43081 | — |
| Oklahoma Medical Research Foundation | Oklahoma City | Oklahoma | 73104 | — |
| Providence Multiple Sclerosis Center | Portland | Oregon | 97225 | — |
| Allegheny Neurological Associates | Pittsburgh | Pennsylvania | 15212 | — |
| Neurology Clinic PC | Cordova | Tennessee | 38018 | — |
| Hope Neurology | Knoxville | Tennessee | 37922 | — |
| Uni of Texas Health Science Center At Houston | Houston | Texas | 77030 | — |
| Bhupesh Dihenia M.D. P.A. | Lubbock | Texas | 79410 | — |
| Central Texas Neurology Consultants | Round Rock | Texas | 78681 | — |
| Neurology Center of San Antonio | San Antonio | Texas | 78212 | — |
| Rocky Mountain MS Clinic | Salt Lake City | Utah | 84103 | — |
| Swedish Neuroscience Institute | Seattle | Washington | 98122 | — |
| MultiCare Health System Institute for Research and Innovation | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02637856, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 26, 2020 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02637856 live on ClinicalTrials.gov.