Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST
Public ClinicalTrials.gov record NCT02657356. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study of the Efficacy and Safety of Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study assesses the safety and efficacy of bardoxolone methyl relative to placebo in patients with connective tissue disease-associated pulmonary arterial hypertension to determine the recommended dose range and evaluate the change from baseline in 6-minute walk distance (6MWD) following 24 weeks of study participation.
Study identification
- NCT ID
- NCT02657356
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 202 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 4, 2016 (Actual)
- Primary completion
- May 7, 2020 (Actual)
- Completion
- May 7, 2020 (Actual)
- Last update posted
- Jun 4, 2025
2016 – 2020
United States locations
- U.S. sites
- 37
- U.S. states
- 21
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center, Phoenix Advanced Lung Disease Institute | Phoenix | Arizona | 85004 | — |
| Arizona Pulmonary Specialists | Phoenix | Arizona | 85012 | — |
| Cedars Sinai Medical Center | Beverly Hills | California | 90211 | — |
| Regents of The University of California | Fresno | California | 93701 | — |
| University of California San Diego | La Jolla | California | 92093 | — |
| David Geffen School of Medicine UCLA | Los Angeles | California | 90095 | — |
| Pacific Pulmonary Research, Inc. | San Diego | California | 92103 | — |
| Santa Barbara Pulmonary Associates | Santa Barbara | California | 93105 | — |
| Harbor - UCLA Medical Center | Torrance | California | 90502 | — |
| Georgetown University Medical Center - Department of Rheumatology | Washington D.C. | District of Columbia | 20007 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Piedmont-Georgia Lung | Austell | Georgia | 30106 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Kentuckiana Pulmonary Associates | Louisville | Kentucky | 40202 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68131 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131 | — |
| NYU Langone Health | New York | New York | 10003 | — |
| University of Rochester - University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Wexner Medical Center at The Ohio State University | Columbus | Ohio | 43210 | — |
| Integris Nazih Zuhdi Transplant Institute | Oklahoma City | Oklahoma | 73120 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | — |
| University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 69 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02657356, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 4, 2025 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02657356 live on ClinicalTrials.gov.