Efficacy Study of Fluconazole to Treat Coccidioidomycosis Pneumonia (Valley Fever)
Public ClinicalTrials.gov record NCT02663674. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled Clinical Trial of Fluconazole as Early Empiric Treatment of Coccidioidomycosis Pneumonia (Valley Fever) in Adults Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (FLEET-Valley Fever)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase IV randomized, double-blinded, placebo-controlled study in 1000 individuals aged 18 years or older, with community acquired pneumonia (CAP) who meet all eligibility criteria in endemic regions. This study is designed to provide data on the effectiveness of early antifungal treatment (Fluconazole, 400 mg/day) for coccidioidomycosis pneumonia (also referred to as Valley Fever (VF) Pneumonia or acute onset valley fever) vs. placebo in subjects with coccidioidomycosis pneumonia. Patients who are prescribed antibacterials by their health care provider for acute CAP will be randomized to receive either placebo or 400 mg/day of fluconazole for 42 days. The primary objective is to assess the clinical response of early empiric antifungal therapy with fluconazole at Day 22 in subjects with coccidioidomycosis pneumonia and are compliant with the study intervention.
Study identification
- NCT ID
- NCT02663674
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 72 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 28, 2015
- Primary completion
- Jun 20, 2018
- Completion
- Jul 30, 2018
- Last update posted
- Jul 4, 2019
2015 – 2018
United States locations
- U.S. sites
- 9
- U.S. states
- 2
- U.S. cities
- 6
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner - University Medical Center Advanced Lung Disease Clinic - Phoenix | Phoenix | Arizona | 85006 | — |
| St Josephs Hospital and Medical Center - Center for Liver Disease and Transplantation - Phoenix | Phoenix | Arizona | 85013 | — |
| Mayo Clinic, Phoenix - Infectious Diseases | Phoenix | Arizona | 85054-4502 | — |
| Mayo Clinic, Scottsdale - Infectious Diseases | Scottsdale | Arizona | 85259-5452 | — |
| The University of Arizona - Banner University Medical Center Tucson Campus - Tucson | Tucson | Arizona | 85724-0001 | — |
| Kaiser Permanente Chester Avenue Medical Offices - Pulmonology | Bakersfield | California | 93301 | — |
| Kern Medical Center - Medicine | Bakersfield | California | 93306-4018 | — |
| UCSF Fresno Center for Medical Education and Research - Clinical Research Center | Fresno | California | 93701 | — |
| Kaiser Permanente Antelope Valley Medical Offices - Infectious Diseases | Lancaster | California | 93534 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02663674, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 4, 2019 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02663674 live on ClinicalTrials.gov.