A Study of Abemaciclib (LY2835219) in Women With HR+, HER2+ Locally Advanced or Metastatic Breast Cancer
Public ClinicalTrials.gov record NCT02675231. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
monarcHER: A Phase 2, Randomized, Multicenter, 3-Arm, Open-Label Study to Compare the Efficacy of Abemaciclib Plus Trastuzumab With or Without Fulvestrant to Standard-of-Care Chemotherapy of Physician's Choice Plus Trastuzumab in Women With HR+, HER2+ Locally Advanced or Metastatic Breast Cancer
Study identification
- NCT ID
- NCT02675231
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Eli Lilly and Company
- Industry
- Enrollment
- 237 participants
Conditions and interventions
Interventions
- Abemaciclib Drug
- Trastuzumab Drug
- Fulvestrant Drug
- Standard of Care Single Agent Chemotherapy Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 22, 2016
- Primary completion
- Apr 7, 2019
- Completion
- Nov 8, 2023
- Last update posted
- Nov 25, 2024
2016 – 2023
United States locations
- U.S. sites
- 32
- U.S. states
- 14
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Comprehensive Blood and Cancer Center | Bakersfield | California | 93309 | — |
| St Jude Medical Center | Fullerton | California | 92835 | — |
| TRIO - Translational Research in Oncology-US, Inc. | Los Angeles | California | 90024 | — |
| USC Norris Cancer Hospital | Los Angeles | California | 90033 | — |
| UCLA Medical Center | Los Angeles | California | 90095 | — |
| Cancer Care Associates Medical Group | Redondo Beach | California | 90277 | — |
| Central Coast Medical Oncology Corporation | Santa Monica | California | 93454 | — |
| Catholic Health Initiatives (CHI) | Englewood | Colorado | 80112 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33908 | — |
| MD Anderson Cancer Center Orlando | Orlando | Florida | 32806 | — |
| University of Miami Plantation | Plantation | Florida | 33324 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Winship Cancer Center Emory University | Atlanta | Georgia | 30322 | — |
| Northside Hospital Cancer Institute | Atlanta | Georgia | 30342 | — |
| Fort Wayne Medical Oncology & Hematology, Inc. | Fort Wayne | Indiana | 46845 | — |
| St Joseph Cancer Center | Lexington | Kentucky | 40509 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Mayo Clinic | Rochester | Minnesota | 55902 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Billings Clinic Research Center | Billings | Montana | 59101 | — |
| Brookdale Hospital Medical Center | Brooklyn | New York | 11212 | — |
| North Shore Hematology Oncology Associates | East Setauket | New York | 11733 | — |
| Clinical Research Alliance, Inc | Lake Success | New York | 11042 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| University of Pennsylvania Hospital | Philadelphia | Pennsylvania | 19104 | — |
| Sarah Cannon Cancer Center | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37203 | — |
| The Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | — |
| Northwest Medical Specialties, PLLC | Puyallup | Washington | 98372 | — |
| Swedish Medical Center | Seattle | Washington | 98104 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 61 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02675231, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 25, 2024 · Synced Jul 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02675231 live on ClinicalTrials.gov.