A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone
Public ClinicalTrials.gov record NCT02675426. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo in Subjects With Moderately to Severely Active Rheumatoid Arthritis Who Are on a Stable Dose of Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) and Have an Inadequate Response to csDMARDs
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objectives of this study are to compare the efficacy, safety, and tolerability of upadacitinib 30 mg once daily (QD) and 15 mg QD versus placebo for the treatment of signs and symptoms of adults with moderately to severely active rheumatoid arthritis who were on a stable dose of csDMARDs and had an inadequate response to csDMARDs.
Study identification
- NCT ID
- NCT02675426
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 661 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 17, 2015 (Actual)
- Primary completion
- Apr 21, 2017 (Actual)
- Completion
- Mar 10, 2022 (Actual)
- Last update posted
- Apr 11, 2023
2015 – 2022
United States locations
- U.S. sites
- 57
- U.S. states
- 23
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AZ Arthritis and Rheum Assoc /ID# 148651 | Mesa | Arizona | 85202 | — |
| SunValley Arthritis Center, Lt /ID# 140452 | Peoria | Arizona | 85381 | — |
| AZ Arthritis and Rheum Researc /ID# 138500 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis and Rheum Researc /ID# 139286 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis & Rheuma Research /ID# 138598 | Phoenix | Arizona | 85032 | — |
| Arizona Research Center, Inc. /ID# 140448 | Phoenix | Arizona | 85053-4061 | — |
| University of Arizona Cancer Center - North Campus /ID# 140451 | Tucson | Arizona | 85719-1478 | — |
| Covina Arthritis Clinic /ID# 139881 | Covina | California | 91722 | — |
| T. Joseph Raoof, MD, Inc. /ID# 140964 | Encino | California | 91436 | — |
| Allergy and Rheum Med Clin /ID# 146082 | La Jolla | California | 92037 | — |
| Pacific Arthritis Ctr Med Grp /ID# 138744 | Los Angeles | California | 90045 | — |
| Robin K. Dore MD, Inc /ID# 138688 | Tustin | California | 92780 | — |
| Inland Rheum Clin Trials Inc. /ID# 138853 | Upland | California | 91786 | — |
| Denver Arthritis Clinic /ID# 139876 | Denver | Colorado | 80230 | — |
| Clinical Res of West FL, Inc. /ID# 138854 | Clearwater | Florida | 33765 | — |
| Ctr Arthritis & Rheumatic Dise /ID# 141696 | Miami | Florida | 33173 | — |
| Medallion Clinical Research Institute, LLC /ID# 140074 | Naples | Florida | 34102 | — |
| Suncoast Clinical Research /ID# 138633 | New Port Richey | Florida | 34652 | — |
| Omega Research Consultants /ID# 139877 | Orlando | Florida | 32810 | — |
| Arthritis Center, Inc. /ID# 141363 | Palm Harbor | Florida | 34684 | — |
| Institute of Arthritis Res /ID# 138548 | Idaho Falls | Idaho | 83404 | — |
| OrthoIllinois /ID# 139695 | Rockford | Illinois | 61114-4937 | — |
| Clinical Investigation Special /ID# 139696 | Skokie | Illinois | 60076 | — |
| Springfield Clinic /ID# 138602 | Springfield | Illinois | 62702-3749 | — |
| Deerbrook Medical Associates /ID# 139694 | Vernon Hills | Illinois | 60061 | — |
| Indiana Univ School of Med /ID# 140077 | Indianapolis | Indiana | 46202 | — |
| Bluegrass Community Research /ID# 138295 | Lexington | Kentucky | 40515 | — |
| Four Rivers Clinical Research /ID# 141134 | Paducah | Kentucky | 42003 | — |
| MMP Women's Health /ID# 141542 | Portland | Maine | 04102 | — |
| The Center for Rheumatology & /ID# 139203 | Wheaton | Maryland | 20902 | — |
| Mansfield Health Center /ID# 141357 | Mansfield | Massachusetts | 02048 | — |
| Advanced Rheumatology, PC /ID# 140071 | Lansing | Michigan | 48910 | — |
| Justus J. Fiechtner, MD, PC /ID# 138697 | Lansing | Michigan | 48910 | — |
| Physician Res. Collaboration /ID# 138533 | Lincoln | Nebraska | 68516 | — |
| Westroads Clinical Research /ID# 138304 | Omaha | Nebraska | 68114 | — |
| The Center for Rheumatology /ID# 138746 | Albany | New York | 12206 | — |
| PMG Research of Salisbury /ID# 141023 | Salisbury | North Carolina | 28144 | — |
| PMG Research of Wilmington LLC /ID# 140951 | Wilmington | North Carolina | 28401 | — |
| Cincinnati Rheumatic Disease Study Group, Inc. /ID# 138868 | Cincinnati | Ohio | 45242-4468 | — |
| Arthritis Assoc of NW Ohio /ID# 140953 | Toledo | Ohio | 43606 | — |
| Health Research Oklahoma /ID# 138535 | Oklahoma City | Oklahoma | 73103-2400 | — |
| Altoona Ctr Clinical Res /ID# 138741 | Duncansville | Pennsylvania | 16635 | — |
| Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 138689 | Summerville | South Carolina | 29486-7887 | — |
| Comprehensive Arthritis Care, a division of Comprehensive Rheumatology Care PLLC /ID# 141021 | Hendersonville | Tennessee | 37075-6213 | — |
| Tekton Research, Inc. /ID# 141428 | Austin | Texas | 78745 | — |
| Trinity Universal Res Assoc /ID# 149271 | Carrollton | Texas | 75007 | — |
| Arth and Osteo Clin Brazo Valley /ID# 147809 | College Station | Texas | 77845 | — |
| Metroplex Clinical Research /ID# 138698 | Dallas | Texas | 75231 | — |
| Baylor College of Medicine /ID# 138682 | Houston | Texas | 77030-3411 | — |
| Houston Institute for Clin Res /ID# 138716 | Houston | Texas | 77074 | — |
| Arthritis Consultants, P.A. /ID# 141138 | Killeen | Texas | 76549 | — |
| Trinity Universal Research Association /ID# 148649 | Plano | Texas | 75024-5283 | — |
| Accurate Clinical Management /ID# 139338 | San Antonio | Texas | 78229 | — |
| Arthritis & Osteoporosis Clinic /ID# 138703 | Waco | Texas | 76710 | — |
| Western Washington Arthritis C /ID# 138728 | Bothell | Washington | 98021 | — |
| Arthritis Northwest, PLLC /ID# 138539 | Spokane | Washington | 99204 | — |
| Aurora Rheumatology and Immunotherapy Center /ID# 139306 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 110 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02675426, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 11, 2023 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02675426 live on ClinicalTrials.gov.