ClinicalTrials.gov record
Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis
ClinicalTrials.gov ID: NCT02686762
Public ClinicalTrials.gov record NCT02686762. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-controlled Trial of Emricasan (IDN-6556-12), an Oral Caspase Inhibitor, in Subjects With Non-alcoholic Steatohepatitis (NASH) Fibrosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, double-blind, randomized, placebo-controlled trial involving subjects with a diagnosis of "definite NASH" with fibrosis (excluding cirrhosis) as determined by the central histopathologist. Upon successful screening, subjects will be randomized to receive either emricasan 50 mg BID or emricasan 5 mg BID or matching placebo BID.
Study identification
- NCT ID
- NCT02686762
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 318 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 25, 2016
- Primary completion
- Jan 28, 2019
- Completion
- Feb 27, 2019
- Last update posted
- Aug 18, 2019
2016 – 2019
United States locations
- U.S. sites
- 83
- U.S. states
- 32
- U.S. cities
- 66
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| University of Arizona Clinical and Translational Sciences Research Center | Tucson | Arizona | 85724 | — |
| Preferred Research Partners, Inc. | Little Rock | Arkansas | 72211 | — |
| Fresno Clinical Research Center | Freestone | California | 93701 | — |
| UCLA The Pfleger Liver Institute | Los Angeles | California | 90024 | — |
| Gastrointestinal Biosciences | Los Angeles | California | 90067 | — |
| Surinder Singh Saini, M.D., Inc. | Newport Beach | California | 92660 | — |
| California Liver Research Institute | Pasadena | California | 91105 | — |
| Inland Empire Liver Foundation | Rialto | California | 92377 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| University of California San Diego Medical Center | San Diego | California | 92103 | — |
| Cedars Sinai Medical Center | West Hollywood | California | 90048 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | — |
| Howard University | Washington D.C. | District of Columbia | 20059 | — |
| UF Hepatology Research at CTRB | Gainesville | Florida | 32610 | — |
| Florida Digestive Health Specialist | Lakewood Rch | Florida | 34211 | — |
| Miami Veterans Administration Healthcare System | Miami | Florida | 33125 | — |
| University of Miami/Schiff Center for Liver Diseases | Miami | Florida | 33136 | — |
| Florida Hospital Orlando Transplant Institute | Orlando | Florida | 32804 | — |
| Tampa General Medical Group | Tampa | Florida | 33606 | — |
| iResearch Atlanta LLC | Decatur | Georgia | 30030 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| The University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Aquiant Research | New Albany | Indiana | 47150 | — |
| Iowa Digestive Disease Center, P.C | Clive | Iowa | 50325 | — |
| UnityPoint Clinic Center For Liver Disease | Des Moines | Iowa | 50309 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Louisiana Research Center, LLC | Shreveport | Louisiana | 71105 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Lahey Clinic Medical Center | Burlington | Massachusetts | 01803 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | — |
| Kansas City Research Institute | Kansas City | Missouri | 64131 | — |
| Washington University School of Medicine-Infectious Disease Clinical Research Unit | St Louis | Missouri | 63110 | — |
| Doctors Office Center | Newark | New Jersey | 07103 | — |
| State University of New York | Buffalo | New York | 14203 | — |
| Northwell Health, Inc. | Manhasset | New York | 11030 | — |
| Mount Sinai Beth Israel Medical Center | New York | New York | 10003 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| Columbia University Medical Center (CUMC) | New York | New York | 10032 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Asheville Gastroenterology Associates, PA | Asheville | North Carolina | 28801 | — |
| Carolinas Healthcare System, Center for Liver Disease | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center, Duke South Clinics | Durham | North Carolina | 27710 | — |
| Rex Healthcare | Raleigh | North Carolina | 27607 | — |
| Consultants for Clinical Research | Cincinnati | Ohio | 45249 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Options Health Research, LLC | Tulsa | Oklahoma | 74104 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Albert Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | — |
| University Gastroenterology | Providence | Rhode Island | 02905 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| PMG Research at Charleston | Charleston | South Carolina | 29461 | — |
| ClinSearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Gastro One | Germantown | Tennessee | 38138 | — |
| Methodist University Hospital | Memphis | Tennessee | 38104 | — |
| Vanderbilt University Medical Center - Digestive Disease Center | Nashville | Tennessee | 37232 | — |
| Texas Clinical Research Institute | Arlington | Texas | 76012 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Baylor All Saints Medical Center | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Liver Associates of Texas, P.A. | Houston | Texas | 77030 | — |
| Research Specialists of Texas | Houston | Texas | 77030 | — |
| Pinnacle Clinical Research, PLLC | Live Oak | Texas | 78233 | — |
| American Research Corporation at the Texas Liver Institue | San Antonio | Texas | 78215 | — |
| Brooke Army Medical Center | San Antonio | Texas | 78219 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84132 | — |
| University of Vermont | Burlington | Vermont | 05405 | — |
| Bon Secours Richmond Health System | Newport News | Virginia | 23602 | — |
| Digestive and Liver Disease Specialists | Norfolk | Virginia | 23502 | — |
| McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| University of Washington Harborview Medical Center | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02686762, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 18, 2019 · Synced Sep 3, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02686762 live on ClinicalTrials.gov.