Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee
Public ClinicalTrials.gov record NCT02697773. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY OF THE ANALGESIC EFFICACY AND SAFETY OF A DOSE TITRATION REGIMEN FOR THE SUBCUTANEOUS ADMINISTRATION OF TANEZUMAB IN SUBJECTS WITH OSTEOARTHRITIS OF THE HIP OR KNEE
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to evaluate the efficacy of a titration arm of tanezumab in which treatment is started at a lower dose (2.5 mg) and increased to a higher dose (5 mg) at Week 8, compared to giving 2 doses of tanezumab 2.5 mg or 2 doses of placebo. The study also evaluates the safety of the treatment regimens.
Study identification
- NCT ID
- NCT02697773
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 698 participants
Conditions and interventions
Conditions
Interventions
- Placebo Other
- Tanezumab 2.5 mg Biological
- Tanezumab 2.5mg/5mg Biological
Other · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 20, 2016
- Primary completion
- Dec 4, 2017
- Completion
- May 13, 2018
- Last update posted
- May 2, 2021
2016 – 2018
United States locations
- U.S. sites
- 68
- U.S. states
- 32
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Orthopaedic Surgeons | Birmingham | Alabama | 35235 | — |
| Cahaba Research, Inc. | Birmingham | Alabama | 35242 | — |
| Arizona Research Center | Phoenix | Arizona | 85023 | — |
| Clinical Research Institute of Arizona, LLC | Surprise | Arizona | 85374 | — |
| Tucson Orthopaedic Institute | Tucson | Arizona | 85714 | — |
| University of Arizona Clinical and Translational Science Research Center | Tucson | Arizona | 85724 | — |
| Baptist Health Center for Clinical Research | Little Rock | Arkansas | 72205 | — |
| Advanced Research Center, Inc | Anaheim | California | 92805 | — |
| Medvin Clinical Research | Covina | California | 91722 | — |
| St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| Irvine Center for Clinical Research | Irvine | California | 92614 | — |
| Robert L Freed, M.D., F.A.C.R / Clinical Interventions Research Institute | Irvine | California | 92618 | — |
| Providence Clinical Research | North Hollywood | California | 91606 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| California Research Foundation | San Diego | California | 92123 | — |
| Inland Rheumatology Clinical Trials, Inc. | Upland | California | 91786 | — |
| Alpine Clinical Research Center | Boulder | Colorado | 80301 | — |
| New England Research Associates, LLC | Bridgeport | Connecticut | 06606 | — |
| Stamford Therapeutics Consortium | Stamford | Connecticut | 06905 | — |
| Clinical Physiology Associates | Fort Myers | Florida | 33912 | — |
| Eastern Research, Inc. | Hialeah | Florida | 33013 | — |
| South Florida Research Center, Inc. | Miami | Florida | 33135 | — |
| New Horizon Research Center | Miami | Florida | 33175 | — |
| Miami Dade Medical Research Institute, LLC | Miami | Florida | 33176 | — |
| Compass Research, LLC | Orlando | Florida | 32806 | — |
| Ormond Beach Clinical Research | Ormond Beach | Florida | 32174 | — |
| Phoenix Clinical Research, LLC | Tamarac | Florida | 33321 | — |
| Bioclinica Research | The Villages | Florida | 32162 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| Center for Advanced Research & Education (CARE) | Gainesville | Georgia | 30501 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Medex Healthcare Research Inc | Chicago | Illinois | 60602 | — |
| Chicago Clinical Research Institute, Inc. | Chicago | Illinois | 60607 | — |
| Northwestern University Feinberg School of Medicine | Chicago | Illinois | 60611 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Investigators Research Group, LLC | Brownsburg | Indiana | 46112 | — |
| Integrated Clinical Trial Services, Inc. | West Des Moines | Iowa | 50265 | — |
| Professional Research Network of Kansas, LLC | Wichita | Kansas | 67205-1138 | — |
| George Stanley Walker, MD | New Orleans | Louisiana | 70115 | — |
| Tristan Medical Enterprises, PC dba Regeneris Medical | North Attleboro | Massachusetts | 02760 | — |
| Michigan Orthopaedic & Spine Surgeons | Rochester Hills | Michigan | 48307 | — |
| Arthritis and Osteoporosis Treatment and Research Center | Flowood | Mississippi | 39232 | — |
| Office Of Stephen H. Miller, M.D. | Las Vegas | Nevada | 89144 | — |
| Arthritis And Osteoporosis Associates | Freehold | New Jersey | 07728 | — |
| New Mexico Clinical Research & Osteoporosis Center, Inc. | Albuquerque | New Mexico | 87106 | — |
| Drug Trials America | Hartsdale | New York | 10530 | — |
| Wake Research Associates, LLC | Raleigh | North Carolina | 27612 | — |
| Plains Clinical Research Center, LLC | Fargo | North Dakota | 58104 | — |
| Prestige Clinical Research | Franklin | Ohio | 45005 | — |
| AC Clinical Research | Tiffin | Ohio | 44883 | — |
| NPC Research | Oklahoma City | Oklahoma | 73109 | — |
| Hillcrest Clinical Research | Oklahoma City | Oklahoma | 73119 | — |
| University Orthopedics Center | State College | Pennsylvania | 16801 | — |
| Palmetto Clinical Trial Services, LLC | Greenville | South Carolina | 29601 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Quality Medical Research | Nashville | Tennessee | 37211 | — |
| KRK Medical Research | Arlington | Texas | 76012 | — |
| Tekton Research, Inc | Austin | Texas | 78745 | — |
| Urgent Care MD's | Baytown | Texas | 77521 | — |
| Arthritis Care and Diagnostic Center | Dallas | Texas | 75231 | — |
| T&R Clinic, PA | Fort Worth | Texas | 76117 | — |
| Centex Studies, Inc. | Houston | Texas | 77058 | — |
| BI Research Center | Houston | Texas | 77084 | — |
| The Pain Relief Center | Plano | Texas | 75024 | — |
| Center for Arthritis and Rheumatic Diseases | Chesapeake | Virginia | 23320 | — |
| Spectrum Medical, Inc | Danville | Virginia | 24541 | — |
| National Clinical Research - Richmond, Inc | Richmond | Virginia | 23294 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 19 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02697773, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2021 · Synced Sep 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02697773 live on ClinicalTrials.gov.