ClinicalTrials.gov record
A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs
ClinicalTrials.gov ID: NCT02706847
Public ClinicalTrials.gov record NCT02706847. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo on Stable Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) in Subjects With Moderately to Severely Active Rheumatoid Arthritis With Inadequate Response or Intolerance to Biologic DMARDs (bDMARDs)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study objective of Period 1 (Day 1 to Week 24) is to compare the safety and efficacy of upadacitinib 30 mg once daily (QD) and 15 mg QD versus placebo for the treatment of signs and symptoms of participants with moderately to severely active rheumatoid arthritis (RA) who are on a stable dose of csDMARDs and had an inadequate response to or intolerance to at least 1 bDMARD. The study objective of Period 2 (Week 24 to Week 260) is to evaluate the long-term safety, tolerability, and efficacy of upadacitinib 15 mg QD and 30 mg QD in participants with RA who completed Period 1.
Study identification
- NCT ID
- NCT02706847
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 499 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 15, 2016 (Actual)
- Primary completion
- Apr 3, 2017 (Actual)
- Completion
- Feb 8, 2022 (Actual)
- Last update posted
- Feb 8, 2023
2016 – 2022
United States locations
- U.S. sites
- 103
- U.S. states
- 33
- U.S. cities
- 88
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheum Assoc of North Alabama /ID# 145959 | Huntsville | Alabama | 35801 | — |
| AZ Arthritis and Rheum Assoc /ID# 148593 | Mesa | Arizona | 85202 | — |
| AZ Arthritis and Rheum Researc /ID# 142816 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis and Rheum Researc /ID# 146075 | Phoenix | Arizona | 85032-9306 | — |
| AZ Arthritis and Rheum Researc /ID# 148592 | Phoenix | Arizona | 85032-9306 | — |
| Arizona Research Center, Inc. /ID# 142741 | Phoenix | Arizona | 85053-4061 | — |
| AZ Arthr & Rheum Research /ID# 155256 | Prescott | Arizona | 86305 | — |
| AZ Arthritis & Rheum Research /ID# 156090 | Sun City | Arizona | 85351 | — |
| NEA Baptist Clinic /ID# 149280 | Jonesboro | Arkansas | 72401 | — |
| Covina Arthritis Clinic /ID# 142794 | Covina | California | 91722 | — |
| Rheumatology Ctr of San Diego /ID# 153576 | Escondido | California | 92025 | — |
| St. Joseph Heritage Healthcare /ID# 149273 | Fullerton | California | 92835 | — |
| TriWest Research Associates- La Mesa /ID# 142792 | La Mesa | California | 91942 | — |
| Arthritis & Osteo Medical Ctr /ID# 142770 | La Palma | California | 90623-1728 | — |
| Valerius Med Grp & Res Ctr /ID# 142799 | Los Alamitos | California | 90720-5402 | — |
| Pacific Arthritis Ctr Med Grp /ID# 142783 | Los Angeles | California | 90045 | — |
| University of California, Los Angeles /ID# 148348 | Los Angeles | California | 90095 | — |
| Desert Medical Advances /ID# 142765 | Palm Desert | California | 92260 | — |
| Stanford University School of Med /ID# 142761 | Stanford | California | 94305-2200 | — |
| Robin K. Dore MD, Inc /ID# 150908 | Tustin | California | 92780 | — |
| Inland Rheum Clin Trials Inc. /ID# 142787 | Upland | California | 91786 | — |
| Medvin Clinical Research /ID# 142814 | Whittier | California | 90606 | — |
| Arthritis Assoc & Osteo Ctr /ID# 142809 | Colorado Springs | Colorado | 80920 | — |
| Denver Arthritis Clinic /ID# 142771 | Denver | Colorado | 80230 | — |
| New England Research Associates, LLC /ID# 142763 | Bridgeport | Connecticut | 06606-1827 | — |
| Delaware Arthritis /ID# 142803 | Lewes | Delaware | 19958 | — |
| Lakes Research, LLC /ID# 142755 | Miami | Florida | 33014 | — |
| Medallion Clinical Research Institute, LLC /ID# 142740 | Naples | Florida | 34102 | — |
| Omega Research Consultants /ID# 142780 | Orlando | Florida | 32810 | — |
| Millennium Research /ID# 142782 | Ormond Beach | Florida | 32174 | — |
| Arthritis Research of Florida /ID# 142811 | Palm Harbor | Florida | 34684-2672 | — |
| Arthritis Center, Inc. /ID# 142822 | Palm Harbor | Florida | 34684 | — |
| Advent Clinical Research /ID# 142817 | Pinellas Park | Florida | 33781 | — |
| St. Anthony Comprehsve Res Ins /ID# 148349 | St. Petersburg | Florida | 33705 | — |
| University of South Florida /ID# 145611 | Tampa | Florida | 33612 | — |
| BayCare Medical Group, Inc. /ID# 142747 | Tampa | Florida | 33614-7101 | — |
| Lovelace Scientific Resources /ID# 142779 | Venice | Florida | 34292 | — |
| Jefrey D. Lieberman, MD, P.C. /ID# 151713 | Decatur | Georgia | 30033 | — |
| Marietta Rheumatology Assoc /ID# 151347 | Marietta | Georgia | 30060 | — |
| St. Luke's Clinic - Rheumatolo /ID# 150923 | Boise | Idaho | 83702 | — |
| Institute of Arthritis Res /ID# 142810 | Idaho Falls | Idaho | 83404 | — |
| Advanced Clinical Research /ID# 153089 | Meridian | Idaho | 83642 | — |
| Great Lakes Clinical Trials /ID# 148341 | Chicago | Illinois | 60640 | — |
| Clinical Investigation Special /ID# 149270 | Skokie | Illinois | 60076 | — |
| Springfield Clinic /ID# 142818 | Springfield | Illinois | 62702-3749 | — |
| Deerbrook Medical Associates /ID# 151712 | Vernon Hills | Illinois | 60061 | — |
| The Arthritis & Diabetes Clinic, Inc. /ID# 142793 | Monroe | Louisiana | 71203 | — |
| Vanguard Medical Research, LLC /ID# 153123 | Shreveport | Louisiana | 71011 | — |
| MMP Women's Health /ID# 145612 | Portland | Maine | 04102 | — |
| The Center for Rheumatology & /ID# 142742 | Wheaton | Maryland | 20902 | — |
| Mansfield Health Center /ID# 147628 | Mansfield | Massachusetts | 02048 | — |
| Clinical Pharmacology Study Gr /ID# 142744 | Worcester | Massachusetts | 01605 | — |
| June DO, PC /ID# 142756 | Lansing | Michigan | 48910 | — |
| North Mississippi Med Clinics /ID# 142781 | Tupelo | Mississippi | 38801 | — |
| Clayton Medical Associates dba Saint Louis Rheumatology /ID# 142745 | St Louis | Missouri | 63119-3845 | — |
| Barbara Caciolo, MD /ID# 142749 | St Louis | Missouri | 63139-2338 | — |
| Westroads Clinical Research /ID# 142802 | Omaha | Nebraska | 68114 | — |
| Dartmouth-Hitchcock Medical Center /ID# 145958 | Lebanon | New Hampshire | 03756 | — |
| Atlantic Coast Research /ID# 148347 | Toms River | New Jersey | 08755 | — |
| Ocean Rheumatology, PA /ID# 142785 | Toms River | New Jersey | 08755 | — |
| The Center for Rheumatology /ID# 142784 | Albany | New York | 12206 | — |
| North Shore University Hospital /ID# 142772 | New Hyde Park | New York | 11040 | — |
| Buffalo Rheumatology /ID# 142766 | Orchard Park | New York | 14127 | — |
| Joint & Muscle Research Instit /ID# 142797 | Charlotte | North Carolina | 28204 | — |
| DJL Clinical Research, PLLC /ID# 142769 | Charlotte | North Carolina | 28210-8508 | — |
| Cape Fear Arthritis Care /ID# 148344 | Leland | North Carolina | 28451 | — |
| Coastal Carolina Health Care /ID# 148351 | New Bern | North Carolina | 28562 | — |
| Shanahan Rheuma & Immuno /ID# 142812 | Raleigh | North Carolina | 27617 | — |
| Trinity Health Med Arts Clinic /ID# 142754 | Minot | North Dakota | 58701 | — |
| Cincinnati Rheumatic Disease Study Group, Inc. /ID# 142791 | Cincinnati | Ohio | 45242-4468 | — |
| STAT Research, Inc. /ID# 142821 | Vandalia | Ohio | 45377-9464 | — |
| Health Research Oklahoma /ID# 142751 | Oklahoma City | Oklahoma | 73103-2400 | — |
| Healthcare Research Consultant /ID# 142815 | Tulsa | Oklahoma | 74135 | — |
| East Penn Rheumatology Assoc /ID# 142790 | Bethlehem | Pennsylvania | 18015 | — |
| Clinical Research Ctr Reading /ID# 151714 | Wyomissing | Pennsylvania | 19610 | — |
| Columbia Arthritis Center /ID# 153728 | Columbia | South Carolina | 29204 | — |
| West Tennessee Research Inst /ID# 142739 | Jackson | Tennessee | 38305 | — |
| Arthritis Associates, PLLC /ID# 142774 | Kingsport | Tennessee | 37660 | — |
| Arthritis Associates, PLLC /ID# 155462 | Kingsport | Tennessee | 37660 | — |
| Dr. Ramesh Gupta /ID# 142767 | Memphis | Tennessee | 38119 | — |
| Tekton Research, Inc. /ID# 142805 | Austin | Texas | 78745 | — |
| Diagnostic Group Integrated He /ID# 148340 | Beaumont | Texas | 77701 | — |
| Arth and Osteo Clin Brazo Valley /ID# 148343 | College Station | Texas | 77845 | — |
| Arthritis Care and Diagnostic /ID# 151344 | Dallas | Texas | 75231 | — |
| Metroplex Clinical Research /ID# 142758 | Dallas | Texas | 75231 | — |
| Rheumatic Disease Clin Res Ctr /ID# 150914 | Houston | Texas | 77004 | — |
| Baylor College of Medicine /ID# 142753 | Houston | Texas | 77030-3411 | — |
| Rheumatology Clinic of Houston /ID# 150915 | Houston | Texas | 77065 | — |
| Houston Institute for Clin Res /ID# 142768 | Houston | Texas | 77074 | — |
| Pioneer Research Solutions, Inc. /ID# 151346 | Houston | Texas | 77098-5294 | — |
| Arthritis & Osteoporosis Assoc /ID# 147567 | Lubbock | Texas | 79424 | — |
| P&I Clinical Research /ID# 151345 | Lufkin | Texas | 75904-3132 | — |
| SW Rheumatology Res. LLC /ID# 142813 | Mesquite | Texas | 75150 | — |
| Trinity Universal Research Association /ID# 149278 | Plano | Texas | 75024-5283 | — |
| Arthritis & Osteo Ctr of S. TX /ID# 142773 | San Antonio | Texas | 78232 | — |
| Arthritis Clinic of Central TX /ID# 148346 | San Marcos | Texas | 78666 | — |
| DM Clinical Research /ID# 151007 | Tomball | Texas | 77375 | — |
| Arthritis & Osteoporosis Clinic /ID# 142760 | Waco | Texas | 76710 | — |
| Western Washington Arthritis C /ID# 142776 | Bothell | Washington | 98021 | — |
| Arthritis Northwest, PLLC /ID# 150924 | Spokane | Washington | 99204 | — |
| The Vancouver Clinic, INC. PS /ID# 147946 | Vancouver | Washington | 98664 | — |
| West Virginia Research Inst /ID# 153087 | South Charleston | West Virginia | 25309 | — |
| Aurora Rheumatology and Immunotherapy Center /ID# 142820 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 85 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02706847, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 8, 2023 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02706847 live on ClinicalTrials.gov.