Memory Improvement Through Nicotine Dosing (MIND) Study
Public ClinicalTrials.gov record NCT02720445. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Long-Term Nicotine Treatment of Mild Cognitive Impairment
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to see if daily transdermal nicotine is able to produce a significant cognitive, clinical and functional improvement in participants with MCI. Neuronal nicotinic receptors have long been known to play a critical role in memory function in preclinical studies, with nicotine improving attention, learning, and memory function. The study will enroll 380 participants for a 2 year period. Participants will be randomized (50:50) to either the transdermal nicotine, beginning at 7mg/day, and increasing to 21mg/day, or placebo skin patch.
Study identification
- NCT ID
- NCT02720445
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 348 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 22, 2017 (Actual)
- Primary completion
- Aug 25, 2025 (Actual)
- Completion
- Sep 16, 2025 (Actual)
- Last update posted
- Sep 17, 2026
2017 – 2025
United States locations
- U.S. sites
- 36
- U.S. states
- 22
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Perseverance Research Center | Scottsdale | Arizona | 85254 | — |
| Central Arkansas Veterans Healthcare System | North Little Rock | Arkansas | 72205 | — |
| USC Rancho Los Amigos | Downey | California | 90242 | — |
| Sharp Neurocognitive Research Center | San Diego | California | 92123 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Nuvance Health Medical Practice Ct, Inc.; Associated Neurologists, PC | Danbury | Connecticut | 06810 | — |
| Georgetown University | Washington D.C. | District of Columbia | 200072145 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Miami Jewish Health Systems | Miami | Florida | 33137 | — |
| Brain Matters Research | Stuart | Florida | 34997 | — |
| Augusta University Movement and Memory Disorders | Augusta | Georgia | 30912 | — |
| Velocity Clinical Research - Boise | Meridian | Idaho | 83642 | — |
| Northwestern University | Chicago | Illinois | 606113010 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Headlands Eastern MA LLC | Plymouth | Massachusetts | 02360 | — |
| University at Buffalo (UBMD) | Buffalo | New York | 14203 | — |
| Velocity Clinical Research - Syracuse | East Syracuse | New York | 13057 | — |
| New York University Medical Center | New York | New York | 100166055 | — |
| Mount Sinai School of Medicine | New York | New York | 100296552 | — |
| Integrative Clinical Trials | New York | New York | 11229 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Central States Research (formerly Tulsa Clinical Research) | Tulsa | Oklahoma | 74104 | — |
| Providence Brain and Spine Institute | Portland | Oregon | 97225 | — |
| LeHigh Valley Hospital | Allentown | Pennsylvania | 18105 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Ralph H. Johnson VA Health Care System | Charleston | South Carolina | 294011113 | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212 | — |
| Houston Methodist Neurological Institute | Houston | Texas | 77030 | — |
| Glenn Biggs Institute at the University of Texas Health | San Antonio | Texas | 78229 | — |
| University of Washington Memory and Brain Wellness Center | Seattle | Washington | 98195 | — |
| Kingfisher Cooperative, LLC | Spokane | Washington | 99202 | — |
| University of Wisconsin | Madison | Wisconsin | 53706 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02720445, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 17, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02720445 live on ClinicalTrials.gov.