ClinicalTrials.gov record
A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov ID: NCT02723994
Public ClinicalTrials.gov record NCT02723994. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia
Study identification
- NCT ID
- NCT02723994
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Incyte Corporation
- Industry
- Enrollment
- 171 participants
Conditions and interventions
Conditions
Interventions
- Asparaginase Erwinia Chrysanthemi Drug
- Cyclophosphamide Drug
- Cytarabine Drug
- Dexamethasone Drug
- Doxorubicin Drug
- Leucovorin Calcium Drug
- Mercaptopurine Drug
- Methotrexate Drug
- Pegaspargase Drug
- Prednisone Drug
- Ruxolitinib Drug
- Thioguanine Drug
- Vincristine Sulfate Drug
Drug
Eligibility (public fields only)
- Age range
- 1 Year to 21 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 29, 2016
- Primary completion
- Mar 2, 2026
- Completion
- Mar 2, 2026
- Last update posted
- Mar 10, 2026
2016 – 2026
United States locations
- U.S. sites
- 103
- U.S. states
- 40
- U.S. cities
- 90
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Childrens Hospital of Alabama | Birmingham | Alabama | 35233 | — |
| Phoenix Children'S Hospital | Phoenix | Arizona | 85016-7710 | — |
| Arkansas Childrens Hospital | Little Rock | Arkansas | 72202 | — |
| Kaiser Permanente | Fontana | California | 92335 | — |
| Loma Linda University Cancer Center | Loma Linda | California | 92350 | — |
| Miller Childrens Hospital Pharmacy | Long Beach | California | 90806 | — |
| Children'S Hospital Los Angeles | Los Angeles | California | 90027 | — |
| Kaiser Foundation Health Plan | Los Angeles | California | 90027 | — |
| Southern California Permanente Medical Group | Los Angeles | California | 90027 | — |
| Valley Childrens Hospital | Madera | California | 93636-8762 | — |
| Choc Children Hospital | Orange | California | 92868 | — |
| Lucille Packard Childrens Hospital | Palo Alto | California | 94304 | — |
| Kaiser Permanente | San Diego | California | 92111 | — |
| Rady Children'S Hospital - San Diego | San Diego | California | 92123 | — |
| Ucsf Pediatric Oncology | San Francisco | California | 94158 | — |
| Kaiser Permanente Downey | Santa Fe Springs | California | 90670 | — |
| Children'S Hospital Colorado | Aurora | Colorado | 80045 | — |
| Connecticut Children'S Medical Ctr | Hartford | Connecticut | 06106 | — |
| Smilow Cancer Center - Yale | New Haven | Connecticut | 06510 | — |
| Alfred I. Dupont Hospital For Children | Wilmington | Delaware | 19803 | — |
| Childrens Hospital of Southwest Florida | Fort Myers | Florida | 33908 | — |
| Joe Dimaggio Children Hospital | Hollywood | Florida | 33021 | — |
| Nemours Childrens Clinic | Jacksonville | Florida | 32207 | — |
| University of Florida Health Shands Hospital | Jacksonville | Florida | 32209 | — |
| Florida Hospital Orlando | Orlando | Florida | 32803 | — |
| Arnold Palmer Hospital For Children | Orlando | Florida | 32806 | — |
| Nemours Childrens Clinic | Pensacola | Florida | 32504 | — |
| All Childrens Hospital | St. Petersburg | Florida | 33701 | — |
| St Josephs Childrens Hospital Tampa | Tampa | Florida | 33607 | — |
| Saint Marys Medical Center | West Palm Beach | Florida | 33407 | — |
| Egleston Children'S Health | Atlanta | Georgia | 30322-1060 | — |
| Kapiolani Medical Center For Women and Children | Honolulu | Hawaii | 96826 | — |
| Ann & Robert H. Lurie Children'S Hospital | Chicago | Illinois | 60611 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153-3328 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Riley Hospital For Children | Indianapolis | Indiana | 46202 | — |
| St Vincent Hospital | Indianapolis | Indiana | 46260 | — |
| Blank Childrens Hospital | Des Moines | Iowa | 50309 | — |
| University of Iowa Hospital and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Kosair Childrens Hospital | Louisville | Kentucky | 40202 | — |
| Ochsner Clinic | New Orleans | Louisiana | 70121 | — |
| Maine Center For Cancer Medicine | Scarborough | Maine | 04074 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287-7049 | — |
| Dana Farber Boston Children'S | Boston | Massachusetts | 02215 | — |
| Cs Mott Childrens Hospital | Ann Arbor | Michigan | 48109 | — |
| Helen Devos Childrens Hosp | Grand Rapids | Michigan | 49503 | — |
| Michigan State University | Lansing | Michigan | 48912 | — |
| Children'S Hospitals and Clinics of Minnesota | Minneapolis | Minnesota | 55404 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| The Children'S Mercy Hospital Outpatient | Kansas City | Missouri | 64108 | — |
| Washington University | St Louis | Missouri | 63130 | — |
| Children'S Hospital & Medical Center | Omaha | Nebraska | 68114 | — |
| Alliance For Childhood Diseases | Las Vegas | Nevada | 89109 | — |
| Children'S Center For Cancer & Blood Dis | Las Vegas | Nevada | 89109 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Morristown Medical Center | Morristown | New Jersey | 07962 | — |
| Rutgers Cancer Institute of Nj | New Brunswick | New Jersey | 08901 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| St Josephs Regional Medical Center | Paterson | New Jersey | 07503 | — |
| University of New Mexico Hospital | Albuquerque | New Mexico | 87131 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14263 | — |
| Cohen Children'S Medical Center | New Hyde Park | New York | 11040 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Nyu Clinical Cancer Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Suny Upstate Medical University | Syracuse | New York | 13210 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| University of North Carolina At Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| Akron Children'S Hospital | Akron | Ohio | 44308 | — |
| Cincinnati Childrens Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Rainbow Babies & Children Hosp | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Nationwide Children'S Hospital | Columbus | Ohio | 43205 | — |
| Dayton Children'S Hospital | Dayton | Ohio | 45404 | — |
| Toledo Hospital | Toledo | Ohio | 43606 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Legacy Emanuel Hospital and Health Center | Portland | Oregon | 97227 | — |
| Doernbecher Childrens Hospital | Portland | Oregon | 97239 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033-2360 | — |
| Children'S Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Childrens Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15224 | — |
| Hasbro Childrens Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Dell Childrens Medical Center of Central Texas | Austin | Texas | 78723 | — |
| Driscoll Children'S Hospital | Corpus Christi | Texas | 78411 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| El Paso Children'S Hospital Corporation | El Paso | Texas | 79905 | — |
| Texas Childrens Hospital | Houston | Texas | 77030 | — |
| University of Texas Health Science Cente | San Antonio | Texas | 78229 | — |
| Primary Children'S Hospital | Salt Lake City | Utah | 84113 | — |
| Children'S Hospital of the | Norfolk | Virginia | 23507 | — |
| Seattle Children'S Hospital | Seattle | Washington | 98105 | — |
| Providence Sacred Heart Medical Center & Children'S Hospital | Spokane | Washington | 99204 | — |
| St Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02723994, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 10, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02723994 live on ClinicalTrials.gov.