ClinicalTrials.gov record
Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer
ClinicalTrials.gov ID: NCT02744092
Public ClinicalTrials.gov record NCT02744092. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Direct Oral Anticoagulants (DOACs) Versus LMWH +/- Warfarin for VTE in Cancer: A Randomized Effectiveness Trial (CANVAS Trial)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The overarching objective of the study is to determine the effectiveness of LMWH/ warfarin vs. DOAC anticoagulation for preventing recurrent VTE in cancer patients. The intervention strategy is Direct Oral AntiCoagulants (DOAC) therapy with edoxaban, apixaban, rivaroxaban, or dabigatran. The comparator is low molecular weight heparin (LMWH) alone or with warfarin. The information gained will empower cancer patients and physicians to make more informed choices about anticoagulation strategies to manage VTE.
Study identification
- NCT ID
- NCT02744092
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 811 participants
Conditions and interventions
Conditions
Interventions
- Rivaroxaban Drug
- Apixaban Drug
- Edoxaban Drug
- Dabigatran Drug
- Warfarin Drug
- Dalteparin Drug
- Enoxaparin Drug
- Fondaparinux Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 12, 2016
- Primary completion
- Oct 30, 2020
- Completion
- Feb 21, 2021
- Last update posted
- Oct 2, 2023
2016 – 2021
United States locations
- U.S. sites
- 151
- U.S. states
- 29
- U.S. cities
- 107
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| South County Hematology | Chula Vista | California | 91911 | — |
| Sharp Rees-Stealy | Chula Vista | California | 91913 | — |
| Washington Hospital Healthcare System | Fremont | California | 94538 | — |
| Washington Hospital | Fremont | California | 94538 | — |
| VA Central California Fresno Medical Center | Fresno | California | 93073 | — |
| Cancer Center Oncology Medical Group | La Mesa | California | 91942 | — |
| Medical Oncology Associates- San Diego | San Diego | California | 92123 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| Sharp Rees-Stealy | San Diego | California | 92123 | — |
| UCSF Medical Center - Mission Bay | San Francisco | California | 94143 | — |
| Saint Joseph's Medical Center | Stockton | California | 95204 | — |
| Middlesex Hospital | Middletown | Connecticut | 06457 | — |
| The Stamford Hospital | Stamford | Connecticut | 06904 | — |
| Morton Plant Hospital | Clearwater | Florida | 33756 | — |
| Breast Cancer Center at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Hollis Cancer Center | Lakeland | Florida | 33805 | — |
| Breast Cancer Center at Memorial Hospital West | Pembroke Pines | Florida | 33028 | — |
| Memorial Cancer Institute at Memorial Hospital West | Pembroke Pines | Florida | 33028 | — |
| Memorial Hospital West | Pembroke Pines | Florida | 33028 | — |
| The Center for Cancer Care-Duluth | Duluth | Georgia | 30096 | — |
| Gwinnett Medical Center | Lawrenceville | Georgia | 30046 | — |
| The Center for Cancer Care-Snellville | Snellville | Georgia | 30078 | — |
| Hawaii Cancer Care POB II | Honolulu | Hawaii | 96813 | — |
| Hawaii Oncology Inc POB I | Honolulu | Hawaii | 96813 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Hawaii Cancer Care Liliha | Honolulu | Hawaii | 96817 | — |
| Hawaii Oncology Inc Kuakini | Honolulu | Hawaii | 96817 | — |
| Kootenai Health | Post Falls | Idaho | 83854 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| Carle on Vermillion | Danville | Illinois | 61938 | — |
| Carle - Effingham | Effingham | Illinois | 62401 | — |
| NorthShore University HealthSystem Evanston Hospital | Evanston | Illinois | 60201 | — |
| NorthShore University HealthSystem Glenbrook Hospital | Glenview | Illinois | 60026 | — |
| NorthShore University HealthSystem Highland Park Hospital | Highland Park | Illinois | 60035 | — |
| Carle - Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| NorthShore University HealthSystem Skokie ACC | Skokie | Illinois | 60076 | — |
| The Carle Foundation Hospital/Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Franciscan St. Francis Health - Indianapolis | Indianapolis | Indiana | 46237 | — |
| Woodland Cancer Care Center | Michigan City | Indiana | 46360 | — |
| Franciscan St. Francis Health - Mooresville | Mooresville | Indiana | 46158 | — |
| Reid Health | Richmond | Indiana | 47374 | — |
| Memorial Hospital at South Bend | South Bend | Indiana | 46601 | — |
| Union Hospital | Terre Haute | Indiana | 47804 | — |
| Saint Elizabeth Medical Center South | Edgewood | Kentucky | 41017 | — |
| Saint Elizabeth Medical Center Fort Thomas | Fort Thomas | Kentucky | 41075 | — |
| Chandler Medical Center - University of Kentucky | Lexington | Kentucky | 40536 | — |
| James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| Norton Hospital | Louisville | Kentucky | 40202 | — |
| University of Louisville Hospital | Louisville | Kentucky | 40202 | — |
| University of Louisville Physicians, PSC | Louisville | Kentucky | 40202 | — |
| University of Louisville, Division of Surgical Oncology | Louisville | Kentucky | 40202 | — |
| Eastern Maine Medical Center | Bangor | Maine | 04401 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889 | — |
| DF/BWCC at Milford Regional Medical Center | Boston | Massachusetts | 01757 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| St. Elizabeth's Medical Center | Brighton | Massachusetts | 02135 | — |
| Lowell General Hospital | Lowell | Massachusetts | 01854 | — |
| South Shore Hospital | South Weymouth | Massachusetts | 02190 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Green Bay Oncology, Ltd./St. Francis Hospital | Escanaba | Michigan | 49829 | — |
| Masonic Cancer Center University of Minnesota Medical Center | Minneapolis | Minnesota | 55455 | — |
| University of Minnesota Health: Clinics and Surgery Center | Minneapolis | Minnesota | 55455 | — |
| University of Minnesota Medical Center, Fairview | Minneapolis | Minnesota | 55455 | — |
| Siteman Cancer Center - St. Peters | City of Saint Peters | Missouri | 63376 | — |
| Veterans Administration/Harry S Truman Memorial Hospital | Columbia | Missouri | 65201 | — |
| Ellis Fischel Cancer Center University of Missouri Healthcare | Columbia | Missouri | 65212 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center - South County | St Louis | Missouri | 63129 | — |
| Siteman Cancer Center - West County | St Louis | Missouri | 63141 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic | Billings | Montana | 59101 | — |
| Montana Cancer Consortium | Billings | Montana | 59102 | — |
| Bozeman Health | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| Nevada Cancer Specialists - Oakey | Las Vegas | Nevada | 89102 | — |
| Ann M Wierman MD LTD | Las Vegas | Nevada | 89128 | — |
| Nevada Cancer Specialists - Tenaya | Las Vegas | Nevada | 89128 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89148 | — |
| Nevada Cancer Specialists - Fort Apache | Las Vegas | Nevada | 89148 | — |
| Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | 89169 | — |
| New Hampshire Oncology - Hematology PA | Concord | New Hampshire | 03301 | — |
| New Hampshire Oncology-Hematology PA | Hooksett | New Hampshire | 03106 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Dana-Farber/New Hampshire Oncology Hematology | Londonderry | New Hampshire | 03053 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| SUNY Upstate Medical University | New York | New York | 13210 | — |
| Mission Hospital - Memorial Campus | Asheville | North Carolina | 28801 | — |
| Southeastern Medical Oncology Center | Clinton | North Carolina | 28328 | — |
| Duke University Health System | Durham | North Carolina | 27710 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| Southeastern Medical Oncology Center | Jacksonville | North Carolina | 28546 | — |
| Kenansville Medical Center | Kenansville | North Carolina | 28349 | — |
| Kinston Medical Specialists, P.A. | Kinston | North Carolina | 28501 | — |
| Lenoir Memorial Hospital | Kinston | North Carolina | 28501 | — |
| Onslow Medical Center | Richlands | North Carolina | 28574 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Dayton Physicians LLC, Miami Valley South | Centerville | Ohio | 45459 | — |
| The James Cancer Hospital and Solove Research Institute | Columbus | Ohio | 43210 | — |
| Dayton Physicians LLC, Samaritan North | Dayton | Ohio | 45415 | — |
| Dayton Clincial Oncology Program | Dayton | Ohio | 45420 | — |
| Veteran Affairs Medical Center | Dayton | Ohio | 45428 | — |
| Wright Patterson Medical Center | Dayton | Ohio | 45433 | — |
| Dayton Physicians LLC, Atrium | Franklin | Ohio | 45005 | — |
| Dayton Physicians, Wayne | Greenville | Ohio | 45331 | — |
| Greater Dayton Cancer Center | Kettering | Ohio | 45409 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Toledo Clinic Cancer Center - Maumee | Maumee | Ohio | 43537 | — |
| Toledo Clinic Cancer Center - Toledo | Toledo | Ohio | 43623 | — |
| Dayton Physicians LLC, Upper valley | Troy | Ohio | 45373 | — |
| WellSpan Health Ephrata Cancer Center | Ephrata | Pennsylvania | 17522 | — |
| WellSpan Health Adams Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| WellSpan Health Sechler Family Cancer Center | Lebanon | Pennsylvania | 17042 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| WellSpan Health York Cancer Center | York | Pennsylvania | 17403 | — |
| Baylor Scott & White Research Institute | Dallas | Texas | 75204 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Augusta Health Cancer Center | Fishersville | Virginia | 22939 | — |
| Fort Belvoir Community Hospital | Fort Belvoir | Virginia | 22060 | — |
| Bon Secours Cancer Institute Medical Oncology at Memorial Regional | Mechanicsville | Virginia | 23116 | — |
| Bon Secours Cancer Institute Medical Oncology at St. Francis | Midlothian | Virginia | 23114 | — |
| Bon Secours Cancer Institute Medical Oncology at St. Mary's | Richmond | Virginia | 23226 | — |
| MultiCare Regional Cancer Center - Auburn | Auburn | Washington | 98001 | — |
| MultiCare Regional Cancer Center - Gig Harbor Medical Park | Gig Harbor | Washington | 98335 | — |
| MultiCare Regional Cancer Center - Puyallup | Puyallup | Washington | 98372 | — |
| Multicare Institute for Research & Innovation | Tacoma | Washington | 98405 | — |
| MultiCare Regional Cancer Center - Tacoma | Tacoma | Washington | 98405 | — |
| Green Bay Oncology, Ltd./HSHS St. Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| HSHS St. Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| Green Bay Oncology, Ltd./HSHS St. Mary's Hospital Medical Center | Green Bay | Wisconsin | 54303 | — |
| HSHS St. Mary's Hospital Medical Center | Green Bay | Wisconsin | 54303 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Green Bay Oncology, Ltd./HSHS St. Clare Memorial Hospital | Oconto Falls | Wisconsin | 54154 | — |
| Green Bay Oncology, Ltd./Door County Memorial Hospital | Sturgeon Bay | Wisconsin | 54135 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02744092, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 2, 2023 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02744092 live on ClinicalTrials.gov.