A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions
Public ClinicalTrials.gov record NCT02746068. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
COAST -1: Clinical Knee Osteoarthritis Symptom Treatment 1 Study. A Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of AXS-02 (Disodium Zoledronate Tetrahydrate) Administered Orally to Subjects With Knee Osteoarthritis Associated With Bone Marrow Lesions.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, double-blind, placebo-controlled, 24-week study to evaluate the efficacy and safety of AXS-02 in subjects with knee osteoarthritis associated with bone marrow lesions.
Study identification
- NCT ID
- NCT02746068
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 346 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2016 (Type not available)
- Primary completion
- Dec 2020 (Estimated)
- Completion
- Dec 2020 (Estimated)
- Last update posted
- Jan 10, 2019
2016 – 2020
United States locations
- U.S. sites
- 54
- U.S. states
- 23
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Achieve Clinical Research | Birmingham | Alabama | 35216 | — |
| Not listed | Birmingham | Alabama | 35216 | — |
| Not listed | Chandler | Arizona | 85224 | — |
| Not listed | Phoenix | Arizona | 85023 | — |
| Not listed | Hot Springs | Arkansas | 71913 | — |
| Not listed | Anaheim | California | 92805 | — |
| Not listed | Canoga Park | California | 91303 | — |
| Not listed | El Cajon | California | 92020 | — |
| Not listed | La Mesa | California | 91941 | — |
| Not listed | Long Beach | California | 90806 | — |
| Not listed | Los Angeles | California | 90036 | — |
| Not listed | North Hollywood | California | 91606 | — |
| Not listed | Sacramento | California | 95821 | — |
| Not listed | San Diego | California | 92103 | — |
| Not listed | Thousand Oaks | California | 91360 | — |
| Not listed | Upland | California | 91786 | — |
| Not listed | Denver | Colorado | 80230 | — |
| Not listed | Milford | Connecticut | 06460 | — |
| Not listed | Boynton Beach | Florida | 33472 | — |
| Not listed | Clearwater | Florida | 33756 | — |
| Not listed | Clermont | Florida | 34711 | — |
| Not listed | Hialeah | Florida | 33012 | — |
| Not listed | Jupiter | Florida | 33458 | — |
| Not listed | Lauderdale Lakes | Florida | 33319 | — |
| Not listed | Orlando | Florida | 32806 | — |
| Accord Clinical Research | Port Orange | Florida | 32129 | — |
| Not listed | Port Saint Lucie | Florida | 34952 | — |
| Not listed | Sarasota | Florida | 34232 | — |
| Not listed | Canton | Georgia | 30114 | — |
| Not listed | Chicago | Illinois | 60611 | — |
| Affinity Clinical Research Institute | Oak Lawn | Illinois | 60453 | — |
| Not listed | Oak Lawn | Illinois | 60453 | — |
| Not listed | Newton | Kansas | 67114 | — |
| Not listed | Wheaton | Maryland | 20902 | — |
| Not listed | Boston | Massachusetts | 02111 | — |
| Not listed | North Attleboro | Massachusetts | 02760 | — |
| Not listed | Quincy | Massachusetts | 02169 | — |
| Not listed | Kansas City | Missouri | 64114 | — |
| Not listed | St Louis | Missouri | 63042 | — |
| Not listed | Albuquerque | New Mexico | 87106 | — |
| Not listed | Hartsdale | New York | 10530 | — |
| Not listed | Rochester | New York | 14618 | — |
| Not listed | Charlotte | North Carolina | 28204 | — |
| Not listed | Raleigh | North Carolina | 27612 | — |
| Not listed | Cincinnati | Ohio | 45227 | — |
| Not listed | Duncansville | Pennsylvania | 16635 | — |
| Not listed | Mt. Pleasant | South Carolina | 29464 | — |
| Not listed | Franklin | Tennessee | 37067 | — |
| Not listed | Austin | Texas | 78745 | — |
| Not listed | Baytown | Texas | 77521 | — |
| Not listed | DeSoto | Texas | 75115 | — |
| Not listed | Wichita Falls | Texas | 76309 | — |
| Not listed | Newport News | Virginia | 23606 | — |
| Not listed | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02746068, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 10, 2019 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02746068 live on ClinicalTrials.gov.