Sapanisertib in Combination With Fulvestrant in Women With Advanced or Metastatic Breast Cancer After Aromatase Inhibitor Therapy
Public ClinicalTrials.gov record NCT02756364. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label Phase 2 Study of MLN0128 (A TORC1/2 Inhibitor) in Combination With Fulvestrant in Women With ER-Positive/HER2-Negative Advanced or Metastatic Breast Cancer That Has Progressed During or After Aromatase Inhibitor Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to compare the progression free survival (PFS) of participants treated with the combination of fulvestrant plus daily sapanisertib and fulvestrant plus weekly sapanisertib versus participants treated with single-agent fulvestrant.
Study identification
- NCT ID
- NCT02756364
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 141 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 28, 2016 (Actual)
- Primary completion
- Nov 25, 2019 (Actual)
- Completion
- Nov 25, 2019 (Actual)
- Last update posted
- Feb 8, 2023
2016 – 2019
United States locations
- U.S. sites
- 30
- U.S. states
- 14
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center, PC | Mobile | Alabama | 36608 | — |
| CBCC Global Research 6501 Truxtun Avenue Bakersfield, CA | Bakersfield | California | 93309 | — |
| St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| UCSD Moores Cancer Center | La Jolla | California | 92037 | — |
| UCLA Hematology/Oncology David Geffen School of Medicine | Los Angeles | California | 90095-7077 | — |
| North County Oncology | Oceanside | California | 92056 | — |
| Torrance Health Association | Redondo Beach | California | 90277 | — |
| PHC-SLO Oncology and Hematology | San Luis Obispo | California | 93401 | — |
| Cancer Center of Santa Barbara With Sansum Clinic | Santa Barbara | California | 93105 | — |
| University of Colorado Cancer Center-Anschutz Cancer Pavilion (ACP) | Aurora | Colorado | 80045 | — |
| St. Mary'S Hospital Regional Cancer Center | Grand Junction | Colorado | 81501 | — |
| Rocky mountain cancer centers LLP | Lakewood | Colorado | 80228 | — |
| Holy Cross Hospital- Bienes Cancer Center | Fort Lauderdale | Florida | 33308 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Orlando Health Inc. | Orlando | Florida | 33806 | — |
| Ft. Wayne Medical Oncology and Hematology, Inc | Fort Wayne | Indiana | 46804 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| Health Partners Institute Park Nicollet Frauenshuh Cancer Center | Saint Louis Park | Minnesota | 55426 | — |
| Comprehensive Cancer Centers of Nevada | Henderson | Nevada | 89074 | — |
| New Jersey Hematology & Oncology Associates | Brick | New Jersey | 8724 | — |
| Northern Westchester Hospital Cancer Treatment & Wellness Center | Mount Kisco | New York | 10549 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Texas Oncology, P.A. | Austin | Texas | 78745 | — |
| Texas Oncology - Presbyterian Hospital | Dallas | Texas | 75231 | — |
| Texas Oncology, P.A. | Dallas | Texas | 75246 | — |
| Texas Oncology- South Second Street | McAllen | Texas | 78503 | — |
| Cancer Care Centers of South Texas | San Antonio | Texas | 78217 | — |
| Texas Oncology,PA. Tyler TX, 75702 | Tyler | Texas | 75702 | — |
| Virginia Cancer Specialist PC | Leesburg | Virginia | 20176 | — |
| West Virginia University School of Medicine | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02756364, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 8, 2023 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02756364 live on ClinicalTrials.gov.