Evaluation of the Efficacy and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Were Taking an Existing Medication Called a Tumour Necrosis Factor Alpha Inhibitor But Had Active Disease
Public ClinicalTrials.gov record NCT02760433. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicenter Phase III Study of the Efficacy and Safety of Olokizumab in Subjects With Moderately to Severely Active Rheumatoid Arthritis Inadequately Controlled by Tumor Necrosis Factor Alpha (TNF-α) Inhibitor Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to determine how effective and safe the study drug Olokizumab was in patients with Rheumatoid Arthritis (RA) who had been already receiving, but not fully responding to treatment with an existing medication called a tumour necrosis factor alpha inhibitor The primary objective of this study was to evaluate the efficacy of olokizumab (OKZ) 64 mg administered subcutaneously (SC) once every 2 weeks (q2w) or once every 4 weeks (q4w) relative to placebo in subjects with moderately to severely active rheumatoid arthritis (RA) inadequately controlled by TNF-α inhibitor (TNFi) therapy.
Study identification
- NCT ID
- NCT02760433
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 368 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 25, 2017 (Actual)
- Primary completion
- Sep 12, 2019 (Actual)
- Completion
- Oct 1, 2019 (Actual)
- Last update posted
- Sep 21, 2023
2017 – 2019
United States locations
- U.S. sites
- 50
- U.S. states
- 22
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Arthritis & Rheumatology Associates, P.C. | Phoenix | Arizona | 85032 | — |
| CHI St. Vincent Hot Springs | Hot Springs | Arkansas | 71913 | — |
| Medvin Clinical Research | Covina | California | 91722 | — |
| TriWest Research Associates, LLC | El Cajon | California | 92020-4124 | — |
| Saint Jude Heritage Medical Grp | Fullerton | California | 92835 | — |
| С V Mehta MD Med Corp. | Hemet | California | 92543 | — |
| Advanced Medical Research, LLC | Lakewood | California | 90623 | — |
| Stanford University School of Medicine | Palo Alto | California | 94304 | — |
| Riverside Medical Clinic | Riverside | California | 92506 | — |
| East Bay Rheumatology Medical Group, Inc. | San Leandro | California | 94578 | — |
| Inland Rheumatology Clinical Trials, Inc. | Upland | California | 91786 | — |
| Denver Arthritis Clinic | Denver | Colorado | 80230 | — |
| Javed Rheumatology Associates | Newark | Delaware | 19713 | — |
| RASF - Clinical Research Center | Boca Raton | Florida | 33486 | — |
| Suncoast Research Group LLC | Miami | Florida | 33135 | — |
| Omega Research Consultants | Orlando | Florida | 32810 | — |
| Family Clinical Trials, LLC. | Pembroke Pines | Florida | 33026 | — |
| AdventHealth Medical Group, PA | Tampa | Florida | 33614 | — |
| Institute of Arthritis Research | Idaho Falls | Idaho | 83404 | — |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | — |
| Graves Gilbert Clinic | Bowling Green | Kentucky | 42101 | — |
| The Arthritis & Diabetes Clinic, Inc. | Monroe | Louisiana | 71203 | — |
| Klein and Associates, M.D., P.A. | Hagerstown | Maryland | 21740 | — |
| The Center for Rheumatology and Bone Research | Wheaton | Maryland | 20902 | — |
| Clinical Pharmacology Study Group | Worcester | Massachusetts | 01605 | — |
| Glacier View Research Instutute-Rheumatology | Kalispell | Montana | 59901 | — |
| Arthritis & Osteoporosis Associates, PA | Freehold | New Jersey | 07728 | — |
| Lovelace Scientific Resources, Inc. | Albuquerque | New Mexico | 87114 | — |
| NYU Langone Ambulatory Care | New York | New York | 11201 | — |
| Medication Management, LLC | Greensboro | North Carolina | 27408 | — |
| Cape Fear Arthritis Care | Leland | North Carolina | 28451 | — |
| Carolina Arthritis Associates | Wilmington | North Carolina | 28401 | — |
| Trinity Medical Group | Minot | North Dakota | 58701 | — |
| Cincinnati Rheumatic Disease Study Group | Cincinnati | Ohio | 45242 | — |
| STAT Research, Inc. | Dayton | Ohio | 45417 | — |
| Clinical Research Source, Inc. | Perrysburg | Ohio | 43606 | — |
| Arthritis Group | Philadelphia | Pennsylvania | 19152 | — |
| Low Country Research Center | Charleston | South Carolina | 29486 | — |
| Amarillo Center for Clinical Research | Amarillo | Texas | 79124 | — |
| Austin Regional Clinic, P.A. | Austin | Texas | 78731 | — |
| Accurate Clinical Research, Inc. | Baytown | Texas | 77521 | — |
| Precision Comprehensive Clinical Research Solutions | Grapevine | Texas | 76034 | — |
| Therapeutic Concepts Rheumatology, LLC | Houston | Texas | 77004 | — |
| Rheumatology Clinic of Houston, P.A. | Houston | Texas | 77065 | — |
| Accurate Clinical Research, Inc. | Houston | Texas | 77089 | — |
| Pioneer Research Solutions, Inc. | Houston | Texas | 77429 | — |
| Accurate Clinical Research, Inc. | League City | Texas | 77573 | — |
| Endocrinology, Internal Medicine | Lubbock | Texas | 79410 | — |
| Dr. Alex De Jesus Rheumatology, P.A. | San Antonio | Texas | 78229 | — |
| Advanced Rheumatology of Houston | Woodville | Texas | 77382 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 66 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02760433, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 21, 2023 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02760433 live on ClinicalTrials.gov.