Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)
Public ClinicalTrials.gov record NCT02766465. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN 1503)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a clinical trial that will compare survival and sickle related outcomes in adolescents and young adults with severe sickle cell disease after bone marrow transplantation and standard of care. The primary outcome is 2-year overall survival.
Study identification
- NCT ID
- NCT02766465
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 138 participants
Conditions and interventions
Conditions
Interventions
- Busulfan Drug
- Fludarabine Drug
- r-ATG Drug
- Hematopoietic Cell Transplant Procedure
- Tacrolimus Drug
- Methotrexate Drug
- Standard of Care Procedure
- Alemtuzumab Drug
- Total Body Irradiation (TBI) Drug
- Sirolimus Drug
- Melphalan Drug
- G-CSF Drug
Drug · Procedure
Eligibility (public fields only)
- Age range
- 15 Years to 40 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 16, 2017 (Actual)
- Primary completion
- May 2, 2023 (Actual)
- Completion
- Aug 2, 2023 (Actual)
- Last update posted
- Apr 18, 2025
2017 – 2023
United States locations
- U.S. sites
- 35
- U.S. states
- 19
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Benioff Children's Hospital at Oakland | Oakland | California | 94609 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| University of Florida Gainsville | Gainesville | Florida | 32611 | — |
| Foundation for Sickle Cell Research/Florida Sickle Inc. | Hollywood | Florida | 33021 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Children's Healthcare of Atlanta | Atlanta | Georgia | 30322 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Augusta University Medical Center | Augusta | Georgia | 30912 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Children's Hospital of New Orleans | New Orleans | Louisiana | 70118 | — |
| Dana Farber Cancer Institute/Brigham & Women's Hospital Brigham and Women's Hospital | Boston | Massachusetts | 02114 | — |
| Dana Farber Cancer Institute/Massachusetts General Hospital Dana-Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Boston University | Boston | Massachusetts | 02215 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Washington University/St. Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| New York Presbyterian Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| Cohen Children's Medical Center | New Hyde Park | New York | 11040 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| Montefiore Medical Center/Albert Einstein School of Medicine | The Bronx | New York | 10467 | — |
| University of North Carolina Hospital at Chapel Hill | Chapel Hill | North Carolina | 27516 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| University of Oklahoma | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health Sciences University | Portland | Oregon | 97239 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| University of Texas Health Sciences Center | Houston | Texas | 77004 | — |
| Baylor College of Medicine/The Methodist Hospital | Houston | Texas | 77030 | — |
| University of Texas/MD Anderson CRC | Houston | Texas | 77030 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02766465, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 18, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02766465 live on ClinicalTrials.gov.