ClinicalTrials.gov record
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure
ClinicalTrials.gov ID: NCT02787044
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Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
INVESTED will test the hypothesis that high dose trivalent influenza vaccine will reduce cardiopulmonary events to a greater extent than standard dose quadrivalent influenza vaccine in high-risk cardiovascular patients with a recent history of myocardial infarction or heart failure. The trial will enroll 9300 participants over one Vanguard (pilot) season and three additional influenza seasons. The primary endpoint will be a composite of all-cause mortality or cardiopulmonary hospitalization.
Study identification
- NCT ID
- NCT02787044
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 5,388 participants
Conditions and interventions
Conditions
Interventions
- High Dose Trivalent Influenza Vaccine Biological
- Standard Dose Quadrivalent Influenza Vaccine Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 1, 2016 (Actual)
- Primary completion
- May 31, 2020 (Actual)
- Completion
- May 31, 2020 (Actual)
- Last update posted
- Jan 21, 2022
2016 – 2020
United States locations
- U.S. sites
- 127
- U.S. states
- 39
- U.S. cities
- 96
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Birmingham VAMC | Birmingham | Alabama | 35233 | — |
| University of Alabama Hypertension Program | Birmingham | Alabama | 35294 | — |
| Heart Center Research, LLC | Huntsville | Alabama | 35801 | — |
| Alaska Heart & Vascular Institute | Anchorage | Alaska | 99508 | — |
| Banner University Medicine North | Tucson | Arizona | 85719 | — |
| University of Arizona- Sarver Heart Center | Tucson | Arizona | 85724 | — |
| CAVHS | Little Rock | Arkansas | 72205 | — |
| VA Loma Linda Healthcare System | Loma Linda | California | 92357 | — |
| Long Beach VAMC | Long Beach | California | 90822 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| VA San Diego Healthcare System | San Diego | California | 92161 | — |
| UCSF Medical Center | San Francisco | California | 94143 | — |
| VA West Haven | West Haven | Connecticut | 06516 | — |
| Washington DC VAMC | Washington D.C. | District of Columbia | 20422 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| N FL/S GA Veterans Health System | Gainesville | Florida | 32608 | — |
| OneFlorida CDRN | Gainesville | Florida | 32611 | — |
| Clearwater Cardiovascular Consultants-Largo | Largo | Florida | 33777 | — |
| Inpatient Research Corporation | Miami | Florida | 33014 | — |
| ITB Research | Miami | Florida | 33173 | — |
| Charlotte Heart Group Research Center | Port Charlotte | Florida | 33952 | — |
| Clearwater Cardiovascular Consultants-SH | Safety Harbor | Florida | 34695 | — |
| Bond Community Health Center, Inc. | Tallahassee | Florida | 32301 | — |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | — |
| Morehouse School of Medicine | Atlanta | Georgia | 30310 | — |
| Atlanta VA Health Care System | Decatur | Georgia | 30033 | — |
| Peidmont Fayette | Fayetteville | Georgia | 30214 | — |
| University of Hawaii | Honolulu | Hawaii | 96813 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Jesse Brown VA Medical Center | Chicago | Illinois | 60612 | — |
| University of Chicago Medicine | Chicago | Illinois | 60637 | — |
| Chicago Medical Research | Hazel Crest | Illinois | 60429 | — |
| Northwester Medicine Lake Forest | Lake Forest | Illinois | 60045 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Captain James A. Lovell Federal Health Care Center | North Chicago | Illinois | 60064 | — |
| UnityPoint Health Methodist | Peoria | Illinois | 61606 | — |
| Central DuPage Hospital | Winfield | Illinois | 60190 | — |
| Krannert Institute of Cardiology | Indianapolis | Indiana | 46202 | — |
| St. Vincent Medical Group | Indianapolis | Indiana | 46260 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| The University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| VA Eastern Kansas Health Care System | Leavenworth | Kansas | 66048 | — |
| Robley Rex VA | Louisville | Kentucky | 40206 | — |
| The Heart Clinic of Hamond | Hammond | Louisiana | 70403 | — |
| Southeast Louisiana Veterans Healthcare System | New Orleans | Louisiana | 70112 | — |
| Ochsner Health System- Baton Rouge | New Orleans | Louisiana | 70121 | — |
| ENRM VA Hospital | Bedford | Massachusetts | 01730 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Brigham and Women's Faulkner Hospital | Boston | Massachusetts | 02130 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Pentucket Medical Associates | Haverhill | Massachusetts | 01830 | — |
| Charles River Medical Associates | Natick | Massachusetts | 01760 | — |
| Boston/West Roxbury VA Hospital | West Roxbury | Massachusetts | 02132 | — |
| VA Boston Healthcase System | West Roxbury | Massachusetts | 02132 | — |
| VA Ann Harbor Healthcare System | Ann Arbor | Michigan | 48105 | — |
| Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| HealthPartners - Riverside Research | Minneapolis | Minnesota | 55454 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| HealthEast Medical Research Institute | Saint Paul | Minnesota | 55102 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | — |
| VA St. Louis Health Care System | St Louis | Missouri | 63106 | — |
| St. Louis University | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Nebraska Heart Institute- Grand Island | Grand Island | Nebraska | 68803 | — |
| Darthmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Cardio Assoc. of the Del. Valley- Elmer | Elmer | New Jersey | 08318 | — |
| Cardio. Assoc. of the Del. Valley- Haddon Heights | Haddon Heights | New Jersey | 08035 | — |
| Cardio. Assoc. of the Del. Valley- Sewell | Sewell | New Jersey | 08080 | — |
| Lourdes Cardiology Services | Voorhees Township | New Jersey | 08043 | — |
| New Mexico VA Health Care System | Albuquerque | New Mexico | 87108 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| New York Presbyterian Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| New York Presbyterian Queens Bayside/Whitestone | Flushing | New York | 11355 | — |
| New York Presbyterian/Queens | Flushing | New York | 11355 | — |
| NYPQ - Cardiology Outpatient Clinic | Flushing | New York | 11355 | — |
| Winthrop University Hospital | Mineola | New York | 11501 | — |
| New York VA | New York | New York | 10010 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| New York Presbyterian | New York | New York | 10021 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| Charles George VA | Asheville | North Carolina | 28805 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke | Durham | North Carolina | 27710 | — |
| Louis Stokes Cleveland VA Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Heart House Research Foundation | Springfield | Ohio | 45504 | — |
| Oregon Health & Science | Portland | Oregon | 97239 | — |
| VA Portland Health Care Systems (VAPHCS) | Portland | Oregon | 97239 | — |
| Temple University | Philadelphia | Pennsylvania | 19140 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Providence VA Medical Center | Providence | Rhode Island | 02908 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| WJB Dorn VAMC | Columbia | South Carolina | 29209 | — |
| Palmetto Research Center, LLC | Spartanburg | South Carolina | 29302 | — |
| VAMC Memphis | Memphis | Tennessee | 38104 | — |
| Meharry Medical College | Nashville | Tennessee | 37208 | — |
| Tennessee Valley Healthcare Systems-Nashville | Nashville | Tennessee | 37212 | — |
| Vanderbilt University | Nashville | Tennessee | 37232 | — |
| Austin Heart- Heart Hospital | Austin | Texas | 78756 | — |
| Baylor Scott and White Heart and Vascular Hospital | Dallas | Texas | 75226 | — |
| Michael E. DeBakey VAMC, Houston | Houston | Texas | 77030 | — |
| Houston Heart & Vascular Associates | Kingwood | Texas | 77339 | — |
| Houston Methodist Research Institute-CCAT Pearland | Pearland | Texas | 77584 | — |
| St. David's Heath & Vascular PLLC | Round Rock | Texas | 78681 | — |
| South Texas Veterans Healthcare System | San Antonio | Texas | 78229 | — |
| STAR Clinical Trials | San Antonio | Texas | 78229 | — |
| Austin Heart San Marcos | San Marcos | Texas | 78666 | — |
| Baylor Scott and White Research Institute | Temple | Texas | 76508 | — |
| University of Utah | Salt Lake City | Utah | 84108 | — |
| George E. Wahlen Dept of VA Affairs Medical Center | Salt Lake City | Utah | 84148 | — |
| VA Medical Center White River Junction | White River Junction | Vermont | 05009 | — |
| Inova Heart and Vascular Institute | Alexandria | Virginia | 22306 | — |
| Carient Heart & Vascular | Manassas | Virginia | 20109 | — |
| Louis A Johnson VAMC | Clarksburg | West Virginia | 26301 | — |
| Gundersen Clinic | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin | Madison | Wisconsin | 53705 | — |
| Willam S. Middleton Memorial Veterans Hospital | Madison | Wisconsin | 53705 | — |
| University of Wisconsin Madison | Madison | Wisconsin | 57305 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Aurora Research Institute, LLC | Milwaukee | Wisconsin | 53233 | — |
| Celement J. Zablocki VA Medical Center | Milwaukee | Wisconsin | 53295 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02787044, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2022 · Synced Nov 11, 2026
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