Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients
Public ClinicalTrials.gov record NCT02796261. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase 3 Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine With Lomustine Compared to Lomustine Alone in Patients With AA That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy.
Study identification
- NCT ID
- NCT02796261
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 343 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2016 (Type not available)
- Primary completion
- Jun 2023 (Estimated)
- Completion
- Jun 2023 (Estimated)
- Last update posted
- Jan 21, 2022
2016 – 2023
United States locations
- U.S. sites
- 47
- U.S. states
- 26
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35401 | — |
| Saint Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Kaiser Permanente | Los Angeles | California | 90027 | — |
| University of Southern California Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| University of California Irvine Medical Center | Orange | California | 92868 | — |
| Kaiser Permanente Center | Redwood City | California | 94063 | — |
| Kaiser Permanente | Sacramento | California | 95825 | — |
| UCSD Moores Cancer Center | San Diego | California | 92093 | — |
| University of California San Francisco Medical Center | San Francisco | California | 94143 | — |
| John Wayne Cancer Institute | Santa Monica | California | 90404 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| University of South Florida (USF) - H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | — |
| Piedmont Physicians Neuro-Oncology | Atlanta | Georgia | 30309 | — |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Northwestern Medicine CDH Cancer Center | Warrenville | Illinois | 60055 | — |
| The University of Iowa | Iowa City | Iowa | 52242 | — |
| University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | — |
| Norton Cancer Institute - Louisville | Louisville | Kentucky | 40202 | — |
| Louisiana State University Health Sciences Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Maine Center for Cancer Medicine and Blood Disorders | Scarborough | Maine | 04074 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana Farber Cancer Institute, Brigham and Women's Hospital Brigham and Women's Hospital | Boston | Massachusetts | 02215 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Mayo Clinic Minnesota | Rochester | Minnesota | 55905 | — |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| HCA Midwest Division | Kansas City | Missouri | 64132 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| JFK Medical Center | Edison | New Jersey | 08820 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University Medical Center, The Neurological Institute | New York | New York | 10032 | — |
| University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| The Cleveland Clinic, Richard E. Jacobs Health Center | Cleveland | Ohio | 44195 | — |
| OhioHealth Research and Innovation Institute | Columbus | Ohio | 43214 | — |
| Providence Brain & Spine Institute | Portland | Oregon | 97225 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Medical University of South Carolina, Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Vanderbilt University | Nashville | Tennessee | 37232 | — |
| Texas Oncology Austin Brain Tumor Center | Austin | Texas | 78705 | — |
| Neuro-Oncology Associates | Dallas | Texas | 75246 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84112 | — |
| Swedish Health Services | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 32 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02796261, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2022 · Synced Nov 3, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02796261 live on ClinicalTrials.gov.