Efficacy and Safety of Nintedanib Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function Impairment
Public ClinicalTrials.gov record NCT02802345. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
INSTAGE: A 24-week, Double-blind, Randomized, Parallel-group Study Evaluating the Efficacy and Safety of Oral Nintedanib Co-administered With Oral Sildenafil, Compared to Treatment With Nintedanib Alone, in Patients With Idiopathic Pulmonary Fibrosis (IPF) and Advanced Lung Function Impairment
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To assess efficacy and safety of concomitant treatment with nintedanib and sildenafil in Idiopathic Pulmonary Fibrosis (IPF) patients with advanced lung function impairment.
Study identification
- NCT ID
- NCT02802345
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 274 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2016 (Actual)
- Primary completion
- Dec 19, 2017 (Actual)
- Completion
- Apr 13, 2018 (Actual)
- Last update posted
- Jan 11, 2019
2016 – 2018
United States locations
- U.S. sites
- 17
- U.S. states
- 15
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Pulmonary Assoc of Stamford | Stamford | Connecticut | 06902-3633 | — |
| University of Florida College of Medicine | Jacksonville | Florida | 32209 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Michigan Clinical Research Unit | Ann Arbor | Michigan | 48109 | — |
| Minnesota Lung Center | Minneapolis | Minnesota | 55407 | — |
| The Lung Research Center, LLC | Chesterfield | Missouri | 63017 | — |
| NewYork-Presbyterian/Weill Cornell Medical Center | New York | New York | 10065 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Clinical Research Solutions | Dayton | Ohio | 45409 | — |
| Mercy Respiratory Specialist | Toledo | Ohio | 43608 | — |
| The Oregon Clinic | Portland | Oregon | 97220 | — |
| Lowcountry Lung and Crit Care | Charleston | South Carolina | 29406 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75235 | — |
| Pulmonary Associates of Richmond, Inc. | Richmond | Virginia | 23225 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 68 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02802345, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 11, 2019 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02802345 live on ClinicalTrials.gov.