Study to Evaluate Safety/Efficacy of a Single Preop Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
Public ClinicalTrials.gov record NCT02807428. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Randomized Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Single Intrathecal Preoperative Administration of AYX1 Injection in Patients Undergoing Unilateral Total Knee Arthroplasty
Study identification
- NCT ID
- NCT02807428
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Adynxx, Inc.
- Industry
- Enrollment
- 210 participants
Conditions and interventions
Conditions
Interventions
- AYX1 Injection 660 mg/6 mL Drug
- Placebo Injection 6 mL Drug
Drug
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 19, 2017
- Primary completion
- Oct 22, 2017
- Completion
- Dec 18, 2017
- Last update posted
- Oct 16, 2018
2017
United States locations
- U.S. sites
- 9
- U.S. states
- 7
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Orthopedic Center | Birmingham | Alabama | 35209 | — |
| Shoals Medical Trials | Sheffield | Alabama | 35660 | — |
| Arizona Research Center | Phoenix | Arizona | 85023 | — |
| CORE Orthopaedic Medical Center | Encinitas | California | 92024 | — |
| Pensacola Research Consultants | Pensacola | Florida | 32503 | — |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | — |
| Mississippi Sports Medicine | Jackson | Mississippi | 39202 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Antria, Inc. | Indiana | Pennsylvania | 15701 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02807428, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2018 · Synced Jul 23, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02807428 live on ClinicalTrials.gov.