Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

ClinicalTrials.gov ID: NCT02810704

Open the official record

This page only displays public information reproduced from the official ClinicalTrials.gov record NCT02810704. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Nov 14, 2026, 11:44 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement: Balancing Safety and Effectiveness

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The anticoagulants being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.

Study identification

NCT ID: NCT02810704
Recruitment status: Completed
Study type: Interventional
Phase: Phase 4
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Enrollment: 18,883 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 21 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 2016 (Actual)
Primary completion: Sep 2025 (Actual)
Completion: Sep 2025 (Actual)
Last update posted: Oct 5, 2026

2016 – 2025

United States locations

U.S. sites: 30
U.S. states: 21
U.S. cities: 26

Facility	City	State	ZIP	Site status
Mayo Clinic	Scottsdale	Arizona	85259	—
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	—
UCLA	Los Angeles	California	90404	—
Stanford University Hospital	Stanford	California	94305	—
Arthritis Surgery Research Foundation	South Miami	Florida	33143	—
Rush University Medical Center	Chicago	Illinois	60612	—
Indiana University	Indianapolis	Indiana	46037	—
Sinai Hospital	Baltimore	Maryland	21215	—
Johns Hopkins University	Baltimore	Maryland	21218	—
Brigham & Women's Hospital	Boston	Massachusetts	02115	—
Boston University Medical Center	Boston	Massachusetts	02118	—
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	—
Lahey Clinic	Burlington	Massachusetts	01805	—
Mayo Clinic	Rochester	Minnesota	55905	—
University of Nebraska Medical Center	Omaha	Nebraska	68198	—
Dartmouth-Hitchcock Medical Center	Lebanon	New Hampshire	03756	—
New York University	New York	New York	10016	—
Northwell Health	New York	New York	10075	—
Duke University Medical Center	Durham	North Carolina	27710	—
Cleveland Clinic	Cleveland	Ohio	44195	—
Penn State Hershey Med Center	Hershey	Pennsylvania	17033	—
University of Pennsylvania	Philadelphia	Pennsylvania	19104	—
Lifespan Health	East Providence	Rhode Island	02914	—
Medical University of South Carolina	Charleston	South Carolina	29425	—
University of Utah	Salt Lake City	Utah	84132	—
Anderson Orthopaedic Institute (VA)	Alexandria	Virginia	22306	—
University of Virginia	Charlottesville	Virginia	22908	—
Virginia Commonwealth University Medical Center	Richmond	Virginia	23284	—
University of Washington	Seattle	Washington	98133	—
West Virginia University	Morgantown	West Virginia	26506	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02810704, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 5, 2026 · Synced Nov 14, 2026