EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study)
Public ClinicalTrials.gov record NCT02816736. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to determine whether, in patients with symptomatic, advanced heart failure due to left ventricular systolic dysfunction, treatment with LCZ696 for 24 weeks will improve Pro-B-type Natriuretic Peptide (NT-proBNP) levels, which reflect hemodynamic and clinical status, compared to treatment with valsartan.
Study identification
- NCT ID
- NCT02816736
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 365 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2, 2017 (Actual)
- Primary completion
- Sep 15, 2020 (Actual)
- Completion
- Sep 29, 2020 (Actual)
- Last update posted
- Dec 3, 2021
2017 – 2020
United States locations
- U.S. sites
- 38
- U.S. states
- 22
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars-Sinai Heart Institute | Beverly Hills | California | 90211 | — |
| Sutter Health Mills-Peninsula Health Services | Sacramento | California | 95816 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453 | — |
| St. Vincent Medical Group | Indianapolis | Indiana | 46260 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63117 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| Charlotte-Mecklenburg Hospital Authority | Charlotte | North Carolina | 28203 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Case Western Medical Center | Cleveland | Ohio | 44106 | — |
| Metro Health System | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Integris Baptist Medical Center | Oklahoma City | Oklahoma | 73112 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Geisinger Medical Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Houston Methodist Research Institute | Houston | Texas | 77030 | — |
| University of Utah School of Medicine | Salt Lake City | Utah | 84132 | — |
| Inova Heart and Vascular Insititute | Falls Church | Virginia | 22042 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02816736, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 3, 2021 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02816736 live on ClinicalTrials.gov.