Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease
Public ClinicalTrials.gov record NCT02819284. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Double-Masked, Randomized, Controlled Study of KPI-121 0.25% Ophthalmic Suspension Compared to Vehicle in Subjects With Dry Eye Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease. The product will be studied over 14 days, with 1-2 drops instilled in each eye four times daily (QID).
Study identification
- NCT ID
- NCT02819284
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 909 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2016 (Actual)
- Primary completion
- Sep 2017 (Actual)
- Completion
- Sep 2017 (Actual)
- Last update posted
- Jan 5, 2021
2016 – 2017
United States locations
- U.S. sites
- 62
- U.S. states
- 24
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB School of Optometry | Birmingham | Alabama | 35294-0010 | — |
| Arizona Eye Center | Chandler | Arizona | 85225 | — |
| NEA Baptist Clinic | Jonesboro | Arkansas | 72401 | — |
| Sall Research Medical Center | Artesia | California | 90701 | — |
| Milton M. Hom, OD, FAAO | Azusa | California | 91702 | — |
| Family Eye Care Center | Campbell | California | 95008 | — |
| Orange County Ophthalmology | Garden Grove | California | 92843 | — |
| Lugene Eye Institute | Glendale | California | 91204 | — |
| The Gavin Herbert Eye Institute | Irvine | California | 92697-4375 | — |
| Macy Eye Center | Los Angeles | California | 90048 | — |
| Advanced Vision Care | Los Angeles | California | 90067 | — |
| North Valley Eye Medical Group | Mission Hills | California | — | — |
| Eye Research Foundation | Newport Beach | California | 92663 | — |
| Arch Health Partners | Poway | California | 92064 | — |
| Martel Eye Medical Group | Rancho Cordova | California | 95670 | — |
| Shasta Eye Medical Group, Inc | Redding | California | 96002 | — |
| West Coast Eye Care Associates | San Diego | California | 92115 | — |
| Wolstan & Goldberg Eye Associates | Torrance | California | 90505 | — |
| Michael K Tran, M.D., Inc. | Westminster | California | 92683 | — |
| Hernando Eye Institute | Brooksville | Florida | 34613 | — |
| Central Florida Eye Associates | Lakeland | Florida | 33805 | — |
| Shettle Eye Research, Inc | Largo | Florida | 33773 | — |
| International Eye Associates PA | Ormond Beach | Florida | 32174 | — |
| Perez Eye Center/International Research Center | Tampa | Florida | 33603 | — |
| Eye Care Centers Management, Inc. (Clayton Eye Center) | Morrow | Georgia | 30260 | — |
| Chicago Cornea Consultants, Ltd. | Hoffman Estates | Illinois | 60169 | — |
| Price Vision Group | Indianapolis | Indiana | 46260 | — |
| John-Kenyon American Eye Institute | New Albany | Indiana | 47150 | — |
| Cincinnati Eye Institute | Edgewood | Kentucky | 41017 | — |
| Koffler Vision Group | Lexington | Kentucky | 40509 | — |
| The Eye Care Institute | Louisville | Kentucky | 40206 | — |
| Taustine Eye Center | Louisville | Kentucky | 40217 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Minnesota Eye Consultants, PA | Bloomington | Minnesota | 55431 | — |
| Tauber Eye Center | Kansas City | Missouri | 64111 | — |
| Tekwani Vision Center | St Louis | Missouri | 63128 | — |
| Comprehensive Eye Care, Ltd. / Vision Research Institute, LLC | Washington | Missouri | 63090 | — |
| Abrams Eye Institute | Las Vegas | Nevada | 89148 | — |
| Raymond Fong, MDPC | New York | New York | 10013 | — |
| Ophthalmic Consultants of Long Island | Rockville Centre | New York | 11570 | — |
| Cornerstone Eye Care | High Point | North Carolina | 27262 | — |
| James D Branch MD | Winston-Salem | North Carolina | 27101 | — |
| Comprehensive Eye Care of Central Ohio | Westerville | Ohio | 43082 | — |
| Drs. Fine, Hoffman & Sims, LLC | Eugene | Oregon | 97401 | — |
| Scott & Christie and Associates, PC | Cranberry Township | Pennsylvania | 16066 | — |
| Eye Care Specialists | Kingston | Pennsylvania | 18704 | — |
| Bucci Laser Vision Institute | Wilkes-Barre | Pennsylvania | 18702 | — |
| Chattanooga Eye Institute, P.C. | Chattanooga | Tennessee | 37411 | — |
| Total Eye Care, PA | Memphis | Tennessee | 38119 | — |
| Toyos Clinic | Nashville | Tennessee | 37215 | — |
| Texan Eye, PA / Keystone Research, Ltd | Austin | Texas | 78731 | — |
| The Cataract and Glaucoma Center | El Paso | Texas | 79902 | — |
| Houston Eye Associates | Houston | Texas | 77024 | — |
| Advanced Laser Vision & Surgical Institute, Intouch Clinical Research Center | Houston | Texas | 77034 | — |
| Whitsett Vision Group | Houston | Texas | 77055 | — |
| The Ocular Surface Institute (TOSI), University of Houston | Houston | Texas | 77204 | — |
| Brazosport Eye Institute | Lake Jackson | Texas | 77566 | — |
| Kozlovsky Delay & Winter Eye Consultants, LLC | San Antonio | Texas | 78230 | — |
| Hoopes Vision | Draper | Utah | 84020 | — |
| Virginia Eye Consultants | Norfolk | Virginia | 23502 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
| Regional Eye Associates | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02819284, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 5, 2021 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02819284 live on ClinicalTrials.gov.