ClinicalTrials.gov record
Combination Chemotherapy With or Without Hypofractionated Radiation Therapy Before Surgery in Treating Patients With Pancreatic Cancer
ClinicalTrials.gov ID: NCT02839343
Public ClinicalTrials.gov record NCT02839343. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Preoperative Extended Chemotherapy vs. Chemotherapy Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase II trial studies how well combination chemotherapy (mFOLFIRINOX) with or without hypofractionated radiation therapy before surgery works in patients with pancreatic cancer that can be removed by surgery. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, fluorouracil, and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. It is not yet known if combination chemotherapy is more effective with or without hypofractionated radiation therapy before surgery in treating patients with pancreatic cancer.
Study identification
- NCT ID
- NCT02839343
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 126 participants
Conditions and interventions
Conditions
Interventions
- radiation therapy Radiation
- surgery Procedure
- mFOLFIRINOX Drug
- FOLFOX Drug
Radiation · Procedure · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2016 (Actual)
- Primary completion
- Nov 30, 2020 (Actual)
- Completion
- Not listed
- Last update posted
- May 24, 2022
Started 2016
United States locations
- U.S. sites
- 154
- U.S. states
- 38
- U.S. cities
- 125
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center PC-Mobile | Mobile | Alabama | 36607 | — |
| Southern Cancer Center PC-Springhill | Mobile | Alabama | 36608 | — |
| University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | 36688 | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch | California | 94531 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| University Oncology Associates | Clovis | California | 93611 | — |
| Kaiser Permanente-Fremont | Fremont | California | 94538 | — |
| Kaiser Permanente-Fresno | Fresno | California | 93720 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Los Angeles County-USC Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Kaiser Permanente-Modesto | Modesto | California | 95356 | — |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Kaiser Permanente-Redwood City | Redwood City | California | 94063 | — |
| Kaiser Permanente-Richmond | Richmond | California | 94801 | — |
| Kaiser Permanente-Roseville | Roseville | California | 95661 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Kaiser Permanente-South Sacramento | Sacramento | California | 95823 | — |
| Kaiser Permanente - Sacramento | Sacramento | California | 95825 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| Kaiser Permanente-San Francisco | San Francisco | California | 94115 | — |
| Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | 95119 | — |
| Kaiser Permanente San Leandro | San Leandro | California | 94577 | — |
| Kaiser Permanente-San Rafael | San Rafael | California | 94903 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | — |
| Kaiser Permanente-Santa Rosa | Santa Rosa | California | 95403 | — |
| Kaiser Permanente-South San Francisco | South San Francisco | California | 94080 | — |
| Kaiser Permanente-Stockton | Stockton | California | 95210 | — |
| Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California | 94086 | — |
| Kaiser Permanente Medical Center-Vacaville | Vacaville | California | 95688 | — |
| Kaiser Permanente-Vallejo | Vallejo | California | 94589 | — |
| Kaiser Permanente-Walnut Creek | Walnut Creek | California | 94596 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | 33021 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Florida Hospital Orlando | Orlando | Florida | 32803 | — |
| Memorial Hospital West | Pembroke Pines | Florida | 33028 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Northwest Community Hospital | Arlington Heights | Illinois | 60005 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | 60026 | — |
| NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | 60035 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Edward Hospital/Cancer Center | Naperville | Illinois | 60540 | — |
| Edward Hospital/Cancer Center?Plainfield | Plainfield | Illinois | 60585 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | 66205 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | — |
| Ochsner Medical Center Jefferson | New Orleans | Louisiana | 70121 | — |
| MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | 04005 | — |
| MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | 04073 | — |
| Maine Medical Center- Scarborough Campus | Scarborough | Maine | 04074 | — |
| Saint Agnes Hospital | Baltimore | Maryland | 21229 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| Ascension Saint Mary's Hospital | Saginaw | Michigan | 48601 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | — |
| University of Missouri - Ellis Fischel | Columbia | Missouri | 65212 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| CHI Health Good Samaritan | Kearney | Nebraska | 68847 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Memorial Sloan Kettering Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Bergen | Montvale | New Jersey | 07645 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08903 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | — |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| NYP/Weill Cornell Medical Center | New York | New York | 10065 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Memorial Sloan Kettering Nassau | Uniondale | New York | 11553 | — |
| Atrium Health Stanly/LCI-Albemarle | Albemarle | North Carolina | 28002 | — |
| Mission Hospital Inc-Memorial Campus | Asheville | North Carolina | 28801 | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | 28203 | — |
| Atrium Health Lincoln/LCI-Lincoln | Charlotte | North Carolina | 28210 | — |
| Levine Cancer Institute-SouthPark | Charlotte | North Carolina | 28211 | — |
| Atrium Health University City/LCI-University | Charlotte | North Carolina | 28262 | — |
| Levine Cancer Institute-Mallard Creek | Charlotte | North Carolina | 28262 | — |
| Levine Cancer Institute-Ballantyne | Charlotte | North Carolina | 28277 | — |
| Atrium Health Cabarrus/LCI-Concord | Concord | North Carolina | 28025 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Atrium Health Union/LCI-Union | Monroe | North Carolina | 28112 | — |
| Atrium Health Cleveland/LCI-Cleveland | Shelby | North Carolina | 28150 | — |
| NHRMC Radiation Oncology - Supply | Supply | North Carolina | 28462 | — |
| New Hanover Regional Medical Center/Zimmer Cancer Center | Wilmington | North Carolina | 28401 | — |
| NHRMC Radiation Oncology - 16th Street | Wilmington | North Carolina | 28401 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| University of Cincinnati/Barrett Cancer Center | Cincinnati | Ohio | 45219 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | — |
| Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | 18015 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Pottstown Hospital | Pottstown | Pennsylvania | 19464 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Greenville Health System Cancer Institute-Faris | Greenville | South Carolina | 29605 | — |
| Greenville Health System Cancer Institute-Eastside | Greenville | South Carolina | 29615 | — |
| Levine Cancer Institute-Rock Hill | Rock Hill | South Carolina | 29732 | — |
| Greenville Health System Cancer Institute-Seneca | Seneca | South Carolina | 29672 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| IMG Hematology Oncology 8501 | Fairfax | Virginia | 22031 | — |
| IMG Hematology Oncology 8505 | Fairfax | Virginia | 22031 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Edwards Comprehensive Cancer Center | Huntington | West Virginia | 25701 | — |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02839343, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 24, 2022 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02839343 live on ClinicalTrials.gov.