ClinicalTrials.gov record
Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction
ClinicalTrials.gov ID: NCT02874794
Public ClinicalTrials.gov record NCT02874794. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-blind, Double-dummy, Parallel Group, Active-controlled, Forced-titration, 12-week Comparison of Combined Angiotensin-neprilysin Inhibition With Sacubitril and Valsartan Versus Enalapril on Changes in Central Aortic Stiffness in Patients With Heart Failure and Reduced Ejection Fraction (HFrEF)
Study identification
- NCT ID
- NCT02874794
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 465 participants
Conditions and interventions
Conditions
Interventions
- Enalapril Drug
- LCZ696 (sacubitril/valsartan) Drug
- Placebo of Enalapril Drug
- Placebo of LCZ696 Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 16, 2016
- Primary completion
- Dec 12, 2018
- Completion
- Jan 25, 2019
- Last update posted
- Jan 4, 2021
2016 – 2019
United States locations
- U.S. sites
- 81
- U.S. states
- 25
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novartis Investigative Site | Birmingham | Alabama | 35294-0006 | — |
| Novartis Investigative Site | Little Rock | Arkansas | 72202 | — |
| Novartis Investigative Site | Beverly Hills | California | 90211 | — |
| Novartis Investigative Site | Huntington Beach | California | 92648 | — |
| Novartis Investigative Site | Newport Beach | California | 92663 | — |
| Novartis Investigative Site | Northridge | California | 91325 | — |
| Novartis Investigative Site | Santa Ana | California | 92704 | — |
| Novartis Investigative Site | Van Nuys | California | 91405 | — |
| Novartis Investigative Site | Greenwich | Connecticut | 06830 | — |
| Novartis Investigative Site | Norwalk | Connecticut | 06851 | — |
| Novartis Investigative Site | Stamford | Connecticut | 06905 | — |
| Novartis Investigative Site | Trumbull | Connecticut | 06611 | — |
| Novartis Investigative Site | Newark | Delaware | 19713 | — |
| Novartis Investigative Site | Atlantis | Florida | 33462 | — |
| Novartis Investigative Site | Aventura | Florida | 33180 | — |
| Novartis Investigative Site | Bradenton | Florida | 34209 | — |
| Novartis Investigative Site | Coral Gables | Florida | 33134 | — |
| Novartis Investigative Site | Daytona Beach | Florida | 32117 | — |
| Novartis Investigative Site | Doral | Florida | 33166 | — |
| Novartis Investigative Site | Fort Lauderdale | Florida | 33312 | — |
| Novartis Investigative Site | Hialeah | Florida | 33012 | — |
| Novartis Investigative Site | Inverness | Florida | 34452 | — |
| Novartis Investigative Site | Jacksonville | Florida | 32223 | — |
| Novartis Investigative Site | Jupiter | Florida | 33458 | — |
| Novartis Investigative Site | Miami | Florida | 33125 | — |
| Novartis Investigative Site | Miami | Florida | 33126 | — |
| Novartis Investigative Site | Miami | Florida | 33133 | — |
| Novartis Investigative Site | Miami | Florida | 33135 | — |
| Novartis Investigative Site | Miami | Florida | 33144 | — |
| Novartis Investigative Site | Miami | Florida | 33155 | — |
| Novartis Investigative Site | Miami | Florida | 33165 | — |
| Novartis Investigative Site | Miami | Florida | 33166 | — |
| Novartis Investigative Site | Miami | Florida | 33176 | — |
| Novartis Investigative Site | Naples | Florida | 34102 | — |
| Novartis Investigative Site | Saint Augustine | Florida | 32086 | — |
| Novartis Investigative Site | Athens | Georgia | 30606 | — |
| Novartis Investigative Site | Augusta | Georgia | 30912 | — |
| Novartis Investigative Site | Blue Ridge | Georgia | 30513 | — |
| Novartis Investigative Site | Eatonton | Georgia | 31024 | — |
| Novartis Investigative Site | Macon | Georgia | 31201 | — |
| Novartis Investigative Site | Coeur d'Alene | Idaho | 83814 | — |
| Novartis Investigative Site | Fairview Heights | Illinois | 62208 | — |
| Novartis Investigative Site | Gurnee | Illinois | 60031 | — |
| Novartis Investigative Site | Overland Park | Kansas | 66209 | — |
| Novartis Investigative Site | Owensboro | Kentucky | 42303 | — |
| Novartis Investigative Site | Baton Rouge | Louisiana | 70808 | — |
| Novartis Investigative Site | Eunice | Louisiana | 70535 | — |
| Novartis Investigative Site | Minden | Louisiana | 71055 | — |
| Novartis Investigative Site | Monroe | Louisiana | 71201 | — |
| Novartis Investigative Site | Slidell | Louisiana | 70458 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21237 | — |
| Novartis Investigative Site | Alpena | Michigan | 49707 | — |
| Novartis Investigative Site | Owosso | Michigan | 48867 | — |
| Novartis Investigative Site | Saginaw | Michigan | 48604 | — |
| Novartis Investigative Site | Lincoln | Nebraska | 68506 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68131 | — |
| Novartis Investigative Site | Las Vegas | Nevada | 89128 | — |
| Novartis Investigative Site | Hillsborough | New Jersey | 08844 | — |
| Novartis Investigative Site | Linden | New Jersey | 07036 | — |
| Novartis Investigative Site | Manalapan | New Jersey | 07726 | — |
| Novartis Investigative Site | Mountain Lakes | New Jersey | 07046 | — |
| Novartis Investigative Site | Buffalo | New York | 14215 | — |
| Novartis Investigative Site | Lake Success | New York | 11042 | — |
| Novartis Investigative Site | Rosedale | New York | 11422 | — |
| Novartis Investigative Site | The Bronx | New York | 10469 | — |
| Novartis Investigative Site | Charlotte | North Carolina | 28227 | — |
| Novartis Investigative Site | Greenville | North Carolina | 27834 | — |
| Novartis Investigative Site | Lenoir | North Carolina | 28645 | — |
| Novartis Investigative Site | Yardley | Pennsylvania | 19067 | — |
| Novartis Investigative Site | Jackson | Tennessee | 38301 | — |
| Novartis Investigative Site | Amarillo | Texas | 79106-4165 | — |
| Novartis Investigative Site | Houston | Texas | 77094 | — |
| Novartis Investigative Site | McKinney | Texas | 75069 | — |
| Novartis Investigative Site | McKinney | Texas | 75071 | — |
| Novartis Investigative Site | Sherman | Texas | 75092 | — |
| Novartis Investigative Site | Tomball | Texas | 77375 | — |
| Novartis Investigative Site | Webster | Texas | 77598 | — |
| Novartis Investigative Site | Richmond | Virginia | 23219 | — |
| Novartis Investigative Site | Richland | Washington | 99352 | — |
| Novartis Investigative Site | Spokane | Washington | 99204 | — |
| Novartis Investigative Site | Manitowoc | Wisconsin | 54220 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02874794, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 4, 2021 · Synced May 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02874794 live on ClinicalTrials.gov.