Effects of Sacubitril/Valsartan Therapy on Biomarkers, Myocardial Remodeling and Outcomes.
Public ClinicalTrials.gov record NCT02887183. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 52 Week, Open Label Evaluation of the Effects of Sacubitril/Valsartan (LCZ696) Therapy on Biomarkers, Myocardial Remodeling and Patient-reported Outcomes in Heart Failure With Reduced Left Ventricular Ejection Fraction.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study was to determine early and more chronic changes in concentrations of biomarkers related to mechanisms of action (MOA) and effects of sacubitril/valsartan therapy over a period of 12 months, and correlated these biomarker changes with cardiac remodeling parameters, patient-reported outcomes and cardiovascular outcomes.
Study identification
- NCT ID
- NCT02887183
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 794 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 25, 2016 (Actual)
- Primary completion
- Oct 22, 2018 (Actual)
- Completion
- Oct 22, 2018 (Actual)
- Last update posted
- Oct 7, 2021
2016 – 2018
United States locations
- U.S. sites
- 77
- U.S. states
- 25
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novartis Investigative Site | Birmingham | Alabama | 35243 | — |
| Novartis Investigative Site | Fort Payne | Alabama | 35967 | — |
| Novartis Investigative Site | Guntersville | Alabama | 35976 | — |
| Novartis Investigative Site | Bakersfield | California | 93308 | — |
| Novartis Investigative Site | Long Beach | California | 90806 | — |
| Novartis Investigative Site | Los Alamitos | California | 90720 | — |
| Novartis Investigative Site | Sylmar | California | 91342 | — |
| Novartis Investigative Site | West Haven | Connecticut | 06516 | — |
| Novartis Investigative Site | Belle Glade | Florida | 33430 | — |
| Novartis Investigative Site | Bradenton | Florida | 34209 | — |
| Novartis Investigative Site | Hollywood | Florida | 33312 | — |
| Novartis Investigative Site | Homestead | Florida | 33030 | — |
| Novartis Investigative Site | Jupiter | Florida | 33458 | — |
| Novartis Investigative Site | Lake Worth | Florida | 334361 | — |
| Novartis Investigative Site | Miami | Florida | 33126 | — |
| Novartis Investigative Site | Miami | Florida | 33133 | — |
| Novartis Investigative Site | Miami | Florida | 33155 | — |
| Novartis Investigative Site | Miami | Florida | 33173 | — |
| Novartis Investigative Site | Port Orange | Florida | 32127 | — |
| Novartis Investigative Site | Wellington | Florida | 33449 | — |
| Novartis Investigative Site | Arlington Heights | Illinois | 60005 | — |
| Novartis Investigative Site | Aurora | Illinois | 60504 | — |
| Novartis Investigative Site | Lombard | Illinois | 60148 | — |
| Novartis Investigative Site | Oak Lawn | Illinois | 60453 | — |
| Novartis Investigative Site | Louisville | Kentucky | 40207 | — |
| Novartis Investigative Site | Owensboro | Kentucky | 42303 | — |
| Novartis Investigative Site | Crowley | Louisiana | 70526 | — |
| Novartis Investigative Site | Shreveport | Louisiana | 71101 | — |
| Novartis Investigative Site | West Monroe | Louisiana | 71291 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21220 | — |
| Novartis Investigative Site | Baltimore | Maryland | 21229 | — |
| Novartis Investigative Site | Columbia | Maryland | 21044 | — |
| Novartis Investigative Site | Boston | Massachusetts | 02114 | — |
| Novartis Investigative Site | Haverhill | Massachusetts | 01830 | — |
| Novartis Investigative Site | Springfield | Massachusetts | 01104 | — |
| Novartis Investigative Site | Kalamazoo | Michigan | 49008 | — |
| Novartis Investigative Site | Minneapolis | Minnesota | 55415 | — |
| Novartis Investigative Site | Belzoni | Mississippi | 39038 | — |
| Novartis Investigative Site | Jackson | Mississippi | 39209 | — |
| Novartis Investigative Site | Southhaven | Mississippi | 38671 | — |
| Novartis Investigative Site | Bozeman | Montana | 59715 | — |
| Novartis Investigative Site | Lincoln | Nebraska | 68506 | — |
| Novartis Investigative Site | Lincoln | Nebraska | 68526 | — |
| Novartis Investigative Site | Omaha | Nebraska | 68114 | — |
| Novartis Investigative Site | Nashua | New Hampshire | 03060 | — |
| Novartis Investigative Site | Buffalo | New York | 14215 | — |
| Novartis Investigative Site | Lake Success | New York | 11042 | — |
| Novartis Investigative Site | Potsdam | New York | 13676 | — |
| Novartis Investigative Site | The Bronx | New York | 10461 | — |
| Novartis Investigative Site | Greensboro | North Carolina | 27410 | — |
| Novartis Investigative Site | Hickory | North Carolina | 28601 | — |
| Novartis Investigative Site | Winston-Salem | North Carolina | 27103 | — |
| Novartis Investigative Site | Hillsboro | Oregon | 97123 | — |
| Novartis Investigative Site | Oregon City | Oregon | 97045 | — |
| Novartis Investigative Site | Portland | Oregon | 97225 | — |
| Novartis Investigative Site | Camp Hill | Pennsylvania | 17011 | — |
| Novartis Investigative Site | Wyomissing | Pennsylvania | 19610 | — |
| Novartis Investigative Site | Yardley | Pennsylvania | 19067 | — |
| Novartis Investigative Site | Simpsonville | South Carolina | 29681 | — |
| Novartis Investigative Site | Germantown | Tennessee | 38138 | — |
| Novartis Investigative Site | Austin | Texas | 78704 | — |
| Novartis Investigative Site | Beaumont | Texas | 77701 | — |
| Novartis Investigative Site | Bryan | Texas | 77802 | — |
| Novartis Investigative Site | Dallas | Texas | 75231 | — |
| Novartis Investigative Site | Houston | Texas | 77081 | — |
| Novartis Investigative Site | Hunstville | Texas | 77340 | — |
| Novartis Investigative Site | McKinney | Texas | 75013 | — |
| Novartis Investigative Site | Sherman | Texas | 75092 | — |
| Novartis Investigative Site | Tomball | Texas | 77375 | — |
| Novartis Investigative Site | Tyler | Texas | 75701 | — |
| Novartis Investigative Site | White River Junction | Vermont | 05009 | — |
| Novartis Investigative Site | Midlothian | Virginia | 23114 | — |
| Novartis Investigative Site | Richmond | Virginia | 23219 | — |
| Novartis Investigative Site | Richmond | Virginia | 23226 | — |
| Novartis Investigative Site | Richmond | Virginia | 23230 | — |
| Novartis Investigative Site | Richmond | Virginia | 23249 | — |
| Novartis Investigative Site | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02887183, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2021 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02887183 live on ClinicalTrials.gov.