Hypofractionated vs. Conventional Regional Nodal Radiation Therapy for Patients With Invasive Breast Cancer
Public ClinicalTrials.gov record NCT02912312. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Shortening Adjuvant Photon Irradiation to Reduce Edema (SAPHIRE): A Randomized Trial of Hypofractionated Versus Conventionally Fractionated Regional Nodal Irradiation for Invasive Breast Cancer
Study identification
- NCT ID
- NCT02912312
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- M.D. Anderson Cancer Center
- Other
- Enrollment
- 805 participants
Conditions and interventions
Conditions
Interventions
- Hypofractionated Radiation Therapy Radiation
- Laboratory Biomarker Analysis Other
- Quality-of-Life Assessment Other
- Questionnaire Administration Other
- Radiation Therapy Radiation
Radiation · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 22, 2017
- Primary completion
- Feb 27, 2030
- Completion
- Feb 27, 2031
- Last update posted
- Jul 14, 2026
2017 – 2031
United States locations
- U.S. sites
- 12
- U.S. states
- 8
- U.S. cities
- 10
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MD Anderson Cancer Center (Banner) | Gilbert | Arizona | 85234 | — |
| Scripps- MD Anderson Cancer | San Diego | California | 92121 | — |
| MD Anderson Cancer Center (Banner)- Northern Colorado | Greeley | Colorado | 80631 | — |
| Baptist - MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Orlando Health Cancer Institute | Orlando | Florida | 32806 | — |
| Community MD Anderson Cancer Center East | Indianapolis | Indiana | 46219 | — |
| Community MD Anderson Cancer Center South | Indianapolis | Indiana | 46227 | — |
| Community MD Anderson Cancer Center North | Indianapolis | Indiana | 49625 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| Ohio Health | Columbus | Ohio | 43215 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| UT Health San Antonio - MD Anderson Cancer Center | San Antonio | Texas | 78229 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02912312, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 14, 2026 · Synced Jul 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02912312 live on ClinicalTrials.gov.