An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT02917993. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and tolerability of itacitinib in combination with osimertinib in subjects with locally advanced or metastatic non-small cell lung cancer (NSCLC).
Study identification
- NCT ID
- NCT02917993
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 59 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 20, 2016 (Actual)
- Primary completion
- Dec 24, 2025 (Actual)
- Completion
- Dec 24, 2025 (Actual)
- Last update posted
- Feb 9, 2026
2016 – 2025
United States locations
- U.S. sites
- 23
- U.S. states
- 15
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California San Diego, 3855 Health Sciences Drive, Mc 0987 | La Jolla | California | 92093 | — |
| University California San Francisco Thoracic Surgery and Oncology Clinic, 1600 Divisadero Street, Floor 4 | San Francisco | California | 94115 | — |
| Innovative Clinical Research Institute, 15111 Whittier Blvd., Suite 216 | Whittier | California | 90603 | — |
| Rocky Mountain Cancer Center, 1800 Williams Street, Suite 200 | Denver | Colorado | 80124 | — |
| Georgetown University Hospital, 3800 Reservoir Rd, NW | Washington D.C. | District of Columbia | 20007 | — |
| Lynn Cancer Center, 701 NW 13th Street, Floor 2 | Boca Raton | Florida | 33486 | — |
| Dana-Farber Cancer Institute, 450 Brookline Avenue | Boston | Massachusetts | 02215 | — |
| Henry Ford Health System, 2799 W Grand Blvd. | Detroit | Michigan | 48202 | — |
| Karmanos Cancer Institute, 4100 John R. street mail Code HW04HO | Detroit | Michigan | 48202 | — |
| Valley Hospital, 223 N Van Dien Avenue | Ridgewood | New Jersey | 07450 | — |
| NYU Langone Medical Center, 160 East 34th Street, Floor 8 | New York | New York | 10016 | — |
| Stony Brook University Medical Center, 3 Edmund D. Pellegrino Road | Stony Brook | New York | 11794 | — |
| Cleveland Clinic, 9500 Euclid Avenue, G Building | Cleveland | Ohio | 44195 | — |
| Earle A. Chiles Research Institute Providence Cancer Center, 4805 NE Glisan Street, 2N35 | Portland | Oregon | 97213 | — |
| St. Luke's University Health Network, 701 Ostrum Street, Suite 403 | Fountain Hill | Pennsylvania | 18015 | — |
| Thomas Jefferson University, 111 S. 11th Street | Philadelphia | Pennsylvania | 19107 | — |
| Texas Oncology - South Austin, 901 West 38th Street, Suite 200 | Austin | Texas | 78705 | — |
| University of Texas -MD Anderson Cancer Center, 1515 Holcombe Blvd. | Houston | Texas | 77030 | — |
| Texas Oncology - San Antonio Medical, 5206 Research Drive | San Antonio | Texas | 78240 | — |
| Texas Oncology-Tyler, 910 E Houston Street, Suite 100 | Tyler | Texas | 75702 | — |
| Huntsman Cancer Institute, 2000 Circle of Hope Drive | Salt Lake City | Utah | 84112 | — |
| US Oncology-Virginia Cancer Specialists, PC, 8503 Arlington Blvd., Suite 400 | Fairfax | Virginia | 22031 | — |
| West Virginia University Cancer Institute, 1 Medical Center Drive | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02917993, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02917993 live on ClinicalTrials.gov.